中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

19 records (took 0.01 seconds)

    SUBSTITUTED N-ACYL HOMOSERINE LACTONES
    3.
    发明申请
    SUBSTITUTED N-ACYL HOMOSERINE LACTONES 审中-公开
    取代的N-乙酰胆碱酯酶

    公开(公告)号：WO2007135466A3

    公开(公告)日：2008-01-10

    申请号：PCT/GB2007050284

    申请日：2007-05-22

    Applicant: SEC DEP FOR DEFENCE AS REPRESE ,  PRITCHARD DAVID IDRIS ,  CHHABRA SIRI RAM

    Inventor： PRITCHARD DAVID IDRIS ,  CHHABRA SIRI RAM

    IPC: C07D307/32 ,  A61K31/341 ,  A61P37/06

    CPC classification number: C07D307/33

    Abstract: The substituted N-acyl homoserine lactones have the formula (I) wherein R is a saturated or unsaturated straight chain or branched chain aliphatic hydrocarbyl group containing from 5 to 14 carbon atoms; R 2 is H or a 1-4C alkyl group; R 3 is H or F; and any enantiomer thereof. These compounds exhibit immunosuppressant activity while exhibiting reduced biosensor (autoinducer) activity compared to known N-acyl homoserine lactones.

    Abstract translation: 取代的N-酰基高丝氨酸内酯具有式（I），其中R是含有5至14个碳原子的饱和或不饱和直链或支链脂族烃基; R 2是H或1-4C烷基; R 3是H或F; 及其任何对映异构体。 与已知的N-酰基高丝氨酸内酯相比，这些化合物表现出免疫抑制剂活性，同时显示出降低的生物传感器（自动诱导剂）活性。

    SUBSTITUTED N-ACYL HOMOSERINE LACTONES
    7.
    发明申请
    SUBSTITUTED N-ACYL HOMOSERINE LACTONES 审中-公开
    取代的N-乙酰胆碱酯酶

    公开(公告)号：WO2007135466A2

    公开(公告)日：2007-11-29

    申请号：PCT/GB2007/050284

    申请日：2007-05-22

    Applicant: THE UNIVERSITY OF NOTTINGHAM ,  PRITCHARD, David Idris ,  CHHABRA, Siri Ram

    Inventor： PRITCHARD, David Idris ,  CHHABRA, Siri Ram

    IPC: C07D307/32 ,  A61K31/341 ,  A61P37/06

    CPC classification number: C07D307/33

    Abstract: The substituted N -acyl homoserine lactones have the formula (I) wherein R is a saturated or unsaturated straight chain or branched chain aliphatic hydrocarbyl group containing from 5 to 14 carbon atoms; R 2 is H or a 1-4C alkyl group; R 3 is H or F; and any enantiomer thereof. These compounds exhibit immunosuppressant activity while exhibiting reduced biosensor (autoinducer) activity compared to known N -acyl homoserine lactones.

    Abstract translation: 取代的N-酰基高丝氨酸内酯具有式（I），其中R是含有5至14个碳原子的饱和或不饱和直链或支链脂族烃基; R 2是H或1-4C烷基; R 3是H或F; 及其任何对映异构体。 与已知的N-酰基高丝氨酸内酯相比，这些化合物表现出免疫抑制剂活性，同时显示出降低的生物传感器（自动诱导剂）活性。

    COMPOSITION AND METHOD FOR TREATMENT OF WOUNDS
    8.
    发明申请
    COMPOSITION AND METHOD FOR TREATMENT OF WOUNDS 审中-公开
    治疗伤口的组合物和方法

    公开(公告)号：WO03043669A8

    公开(公告)日：2003-10-02

    申请号：PCT/GB0205171

    申请日：2002-11-18

    Applicant: UNIV NOTTINGHAM ,  PRITCHARD DAVID IDRIS

    Inventor： PRITCHARD DAVID IDRIS

    IPC: A61L15/44 ,  A61K35/64 ,  A61K38/00 ,  A61K38/46 ,  A61K38/48 ,  A61K45/00 ,  A61L15/38 ,  A61L15/40 ,  A61P17/02 ,  C07K14/435

    CPC classification number: C07K14/43577 ,  A61K38/00 ,  A61K38/482 ,  A61L15/38 ,  A61L15/40 ,  A61K2300/00

    Abstract: A composition for treatment of a wound to promote healing thereof in a human or non-human mammal comprises an active amount of a toll receptor (or toll-like receptor) ligand, or a precursor thereof, and a suitable carrier. The ligand may be a spatzle or spatzle-like protein derived from an insect, such as Drosophila melanogaster or Lucilia sericata. The invention also relates to a method of treating a wound which comprises applying to the wound a composition according to the invention, and a dressing for a wound which comprises a support carrying composition according to the invention.

    Abstract translation: 用于治疗伤口以促进其在人或非人哺乳动物中的组合物包含活性量的通过量受体（或toll样受体）配体或其前体和合适的载体。 配体可以是衍生自昆虫的漱口或类似于蛋白质的蛋白质，例如果蝇（Drosophila melanogaster）或丝绢丝菌（Lucilia sericata）。 本发明还涉及一种治疗伤口的方法，其包括向伤口施用根据本发明的组合物和包含根据本发明的支持载体组合物的伤口敷料。

    TREATMENT OF SURFACES POPULATED BY BACTERIA WITH A LUCILIA SERICATA EXTRACT
    9.
    发明申请
    TREATMENT OF SURFACES POPULATED BY BACTERIA WITH A LUCILIA SERICATA EXTRACT 审中-公开

    公开(公告)号：WO2003075654A3

    公开(公告)日：2003-09-18

    申请号：PCT/GB2003/000959

    申请日：2003-03-06

    Applicant: THE UNIVERSITY OF NOTTINGHAM ,  PRITCHARD, David, Idris

    Inventor： PRITCHARD, David, Idris

    IPC: A61K35/64

    Abstract: A surface populated by a bacteria capable of producing a biofilm is treated beneficially by contacting it with a substance having N-acyl homoserine lactone degradant activity obtained from the secretions and/or excretions of the larval form of the green bottle fly, Lucilia sericata. Furthermore, a synergistic effect is achieved when the larval secretions/excretions are used in combination with an antibiotic, e.g. tetracycline. Such a substance having N-acyl homoserine lactone degradant activity obtained from Lucilia sericata larval secretions and/or excretions also forms part of the invention.

    COMPOSITION AND METHOD FOR TREATMENT OF WOUNDS
    10.
    发明申请
    COMPOSITION AND METHOD FOR TREATMENT OF WOUNDS 审中-公开
    用于治疗创伤的组合物和方法

    公开(公告)号：WO2003043669A1

    公开(公告)日：2003-05-30

    申请号：PCT/GB2002/005171

    申请日：2002-11-18

    Applicant: THE UNIVERSITY OF NOTTINGHAM ,  PRITCHARD, David, Idris

    Inventor： PRITCHARD, David, Idris

    IPC: A61L15/38

    CPC classification number: C07K14/43577 ,  A61K38/00 ,  A61K38/482 ,  A61L15/38 ,  A61L15/40 ,  A61K2300/00

    Abstract: A composition for treatment of a wound to promote healing thereof in a human or non-human mammal comprises an active amount of a toll receptor (or toll-like receptor) ligand, or a precursor thereof, and a suitable carrier. The ligand may be a spatzle or spatzle-like protein derived from an insect, such as Drosophila melanogaster or Lucilia sericata . The invention also relates to a method of treating a wound which comprises applying to the wound a composition according to the invention, and a dressing for a wound which comprises a support carrying composition according to the invention.

    Abstract translation: 用于治疗伤口以促进其在人类或非人类哺乳动物中愈合的组合物包含有效量的toll受体（或toll样受体）配体或其前体，和 一个合适的载体。 该配体可以是来源于昆虫如黑腹果蝇或丝光绿蝇的Spatzle或Spatzle样蛋白质。 本发明还涉及一种处理伤口的方法，其包括向伤口施用根据本发明的组合物和用于伤口的敷料，所述敷料包含根据本发明的载体组合物。

Patent Agency Ranking