公开(公告)号：WO2023049302A1

公开(公告)日：2023-03-30

申请号：PCT/US2022/044457

申请日：2022-09-22

Applicant: PROCAPS SA

Inventor： GUTIERREZ, Wilson, Martinez ,  PADILLA, Alvaro, Jose Garcia ,  SIMANCA, Alfredo, de Jesús Puche ,  BUSTILLO, Tatiana, Lucia Yepes

IPC: A61K9/48 ,  A61K31/23 ,  A61K31/685 ,  A61K47/14 ,  A61K47/24 ,  A23L33/115 ,  C12P7/6481

Abstract: The invention provides a process of incorporation of omega- 3 fatty acids such as EPA/DHA into polar lipid molecules present in lecithin, which consists of: (a) an enzymatic exchange reaction between the fatty acids present in the polar lipids of lecithin and the omega-3 fatty acids present in concentrated fish oil, to obtain an oil with a high content of polar lipids and omega-3 fatty acids and (b) a stage of concentration of the polar lipid content of the oil obtained in stage a, by supercritical fractionation or molecular distillation.

公开(公告)号：WO2022020826A1

公开(公告)日：2022-01-27

申请号：PCT/US2021/051842

申请日：2021-09-23

Applicant: PROCAPS SA

Inventor： ALTAMAR, Carlos, Salazar ,  PARDON, Braulio Fabion, Teran ,  ANAYA, Gustavo ,  NAVARRO, Newman, Aguas ,  HERRERA, Wilmer ,  ARRIETA, Pompilio Rafael, Celedon ,  BLANCO, Claudia Andrea, Silva ,  HERNANDEZ, Diego Rafael, Monterroza ,  CASTRO, Rahumir Alfredo, Gutierrez

IPC: A61K9/54 ,  A61K45/06 ,  A61K45/08 ,  A61K31/192 ,  A61K31/196 ,  A61K31/415 ,  A61K9/4808 ,  A61K9/4825 ,  A61K9/4858 ,  A61K9/4866

Abstract: A softgel capsule having incorporated within said capsule: (i) an active pharmaceutical ingredient in a liquid carrier exhibiting release profiles selected from the group consisting of immediate release, extended release and combinations thereof; and (ii) one or more smaller capsules or smaller solid dosage forms wherein said smaller capsules or smaller solid dosage forms have active ingredients that are compatible or not compatible with each other or with another active within the softgel capsule and wherein said smaller capsules or smaller solid dosage forms exhibit release profiles selected from the group consisting of extended release, and immediate release and combinations thereof.

公开(公告)号：WO2021260649A1

公开(公告)日：2021-12-30

申请号：PCT/IB2021/055702

申请日：2021-06-25

Applicant: PROCAPS SA

Inventor： SALAZAR ALTAMAR, Carlos ,  ANGRES, Isaac

IPC: A41D13/11 ,  A01N25/30 ,  A01N25/34 ,  A01N55/02 ,  A62B23/025 ,  B05D3/02 ,  D06M13/503 ,  D06M2101/20 ,  D06P5/30

Abstract: The invention provides a filter fabric for providing anti pathogenic properties which has been coated with a composition comprising (a) 0.0001-99.9999% by weight of a compound of such as zinc pyrithione and (b) 0.0001-99.9999% by weight of an additional zinc salt selected from the group consisting of zinc acetate, zinc propionate, zinc oxalate, zinc benzoate, zinc gluconate, zinc ascorbate, zinc citrate, zinc lactate, zinc glycolate, zinc maleate, zinc fumarate, zinc polyacrylate and zinc polymaleate. The invention also provides a composition for imparting anti-viral properties to a breathable substrate material comprising two or more zinc salts selected from the group consisting of zinc acetate, zinc propionate, zinc oxalate, zinc benzoate, zinc gluconate, zinc ascorbate, zinc citrate, zinc lactate, zinc glycolate, zinc maleate, zinc fumarate, zinc EDTA, zinc glycinate, zinc polyacrylate, zinc polylactate, zinc polyglycolate and zinc polymaleate said zinc salts being present in effective amounts to impart anti-pathogenic properties.

公开(公告)号：WO2012017325A2

公开(公告)日：2012-02-09

申请号：PCT/IB2011/002443

申请日：2011-07-18

Applicant: PROCAPS SA ,  ALTAMAR, Carlos Salazar ,  ANAYA, Gustavo ,  TERAN, Braulio ,  NAVARRO, Newman Aguas ,  HERRERA, Wilmer

Inventor： ALTAMAR, Carlos Salazar ,  ANAYA, Gustavo ,  TERAN, Braulio ,  NAVARRO, Newman Aguas ,  HERRERA, Wilmer

IPC: A61J3/07

CPC classification number: A61J3/07 ,  A61K9/4808 ,  A61K9/4833

Abstract: The invention provides an apparatus for producing soft gel capsules having encapsulated therein microparticles, nanoparticles and fluids, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies; (d) a liquid fill system (medicine pump system); (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) one or more microgranule or nanogranule feeders located on each side of the rotary dies, said feeders being synchronized to rotate at the same tangential speed as the rotary dies.

Abstract translation: 本发明提供了一种用于生产其中封装有微粒，纳米粒子和流体的软凝胶胶囊的设备，所述设备包括：（a）两个扩张器盒; （b）两个铸造鼓; （c）一对旋转模具; （d）液体填充系统（药物泵系统）; （e）用于加热明胶条并供给所述填充物的楔形物; 和（f）位于旋转模具每一侧的一个或多个微粒或纳米颗粒进料器，所述进料器同步以与旋转模具相同的切向速度旋转。

公开(公告)号：WO2012017326A3

公开(公告)日：2012-04-26

申请号：PCT/IB2011002446

申请日：2011-07-18

Applicant: PROCAPS SA ,  ALTAMAR CARLOS SALAZAR ,  ANAYA GUSTAVO ,  TERAN BRAULIO ,  NAVARRO NEWMAN AGUAS ,  HERRERA WILMER

Inventor： ALTAMAR CARLOS SALAZAR ,  ANAYA GUSTAVO ,  TERAN BRAULIO ,  NAVARRO NEWMAN AGUAS ,  HERRERA WILMER

IPC: A61J3/07 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/22 ,  A61K9/48 ,  A61K31/00

CPC classification number: A61K9/4808 ,  A61J3/07 ,  A61J7/0076 ,  A61K9/4833 ,  A61K31/60 ,  A61K45/06 ,  B65D83/04

Abstract: The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.

Abstract translation: 本发明提供了一种用于制备其中掺入其中的其它固体剂型的软胶囊的装置和方法，其中选自丸粒，较小胶囊，较小片剂，缓释固体剂型，立即释放固体剂型，延长释放固体剂型 和零级释放固体剂型，所述装置包括：（a）两个扩张器盒; （b）两个铸桶; （c）一对具有抽吸装置的旋转模具; （d）液体填充系统; （e）用于加热明胶带并进料所述填充物的楔子; 和（f）两个侧向分配装置，所述侧向分配装置包括具有所述固体剂型的料斗，用于输送所述固体剂型的通道导向件和用于将所述固体剂型分配到形成在所述旋转模具中的软胶囊中的抓取爪。

公开(公告)号：WO2012017326A2

公开(公告)日：2012-02-09

申请号：PCT/IB2011/002446

申请日：2011-07-18

Applicant: PROCAPS SA ,  ALTAMAR, Carlos Salazar ,  ANAYA, Gustavo ,  TERAN, Braulio ,  NAVARRO, Newman Aguas ,  HERRERA, Wilmer

Inventor： ALTAMAR, Carlos Salazar ,  ANAYA, Gustavo ,  TERAN, Braulio ,  NAVARRO, Newman Aguas ,  HERRERA, Wilmer

IPC: A61J3/07

CPC classification number: A61K9/4808 ,  A61J3/07 ,  A61J7/0076 ,  A61K9/4833 ,  A61K31/60 ,  A61K45/06 ,  B65D83/04

Abstract: The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.

Abstract translation: 本发明提供了一种用于制造具有掺入其中的其他固体剂型的软胶囊的设备和方法，所述固体剂型选自丸剂，较小胶囊，较小片剂，持续释放固体剂型，速释固体 剂型，延长释放固体剂型和零级释放固体剂型，所述装置包括：（a）两个扩张器盒; （b）两个铸造鼓; （c）具有抽吸装置的一对旋转模具; （d）液体填充系统; （e）用于加热明胶条并供给所述填充物的楔形物; （f）两个侧向分配装置，所述侧向分配装置包括具有所述固体剂型的料斗，用于运送所述固体剂型的通道导管和用于将所述固体剂型分配到旋转模具中形成的软胶囊中的抓爪。

公开(公告)号：WO2012010980A2

公开(公告)日：2012-01-26

申请号：PCT/IB2011002451

申请日：2011-07-18

Applicant: PROCAPS SA ,  ALTAMAR CARLOS SALAZAR ,  TORRES ORLANDO ,  TERAN BRAULIO ,  ANAYA GUSTAVO ,  NAVARRO NEWMAN AGUAS ,  HERRERA WILMER

Inventor： ALTAMAR CARLOS SALAZAR ,  TORRES ORLANDO ,  TERAN BRAULIO ,  ANAYA GUSTAVO ,  NAVARRO NEWMAN AGUAS ,  HERRERA WILMER

IPC: A61K9/48

CPC classification number: A61J3/07 ,  A61K9/4833 ,  A61K9/4866

Abstract: An apparatus for making softgel capsules comprising: two extrusion nozzles; two cooling and tension rollers; two rotary dies; a wedge; and a filling station. A method is also provided for for producing softgel capsules, comprising the steps of: (a) softening or melting a suitable film forming composition; (b) extruding said suitable film forming composition through two extrusion dies directly into two tension rollers; (c) passing the extruded films over rotating dies; (d) simultaneously forming, filling, heat-sealing and cutting capsules; and (e) washing and drying said capsules.

Abstract translation: 一种制造软胶囊的设备，包括：两个挤压喷嘴; 两个冷却和张力辊; 两个旋转模具; 一个楔子; 和一个加油站。 还提供了用于生产软胶囊的方法，其包括以下步骤：（a）软化或熔化合适的成膜组合物; （b）通过两个挤出模头将所述合适的成膜组合物直接挤出到两个张紧辊中; （c）将挤出的薄膜通过旋转模具; （d）同时成形，填充，热封和切割胶囊; 和（e）洗涤和干燥所述胶囊。

公开(公告)号：WO2023049535A2

公开(公告)日：2023-03-30

申请号：PCT/US2022/050806

申请日：2022-11-22

Applicant: PROCAPS SA

Inventor： MARTINEZ GUTIERREZ, Wilson ,  GARCIA PADILLA, Alvaro, Jose ,  PUCHE SIMANCA, Alfredo de Jesus ,  YEPES BUSTILLO, Tatiana, Lucia

Abstract: The invention provides a process of incorporation of omega-3 fatty acids such as EPA/DHA into polar lipid molecules present in lecithin, which consists of: (a) an enzymatic exchange reaction between the fatty acids present in the polar lipids of lecithin and the omega-3 fatty acids present in concentrated fish oil, to obtain an oil with a high content of polar lipids and omega-3 fatty acids and (b) a stage of concentration of the polar lipid content of the oil obtained in stage a, by supercritical fractionation or molecular distillation.

公开(公告)号：WO2022197983A1

公开(公告)日：2022-09-22

申请号：PCT/US2022/020835

申请日：2022-03-17

Applicant: PROCAPS SA

Inventor： ALTAMAR, Carlos Salazar ,  PADRÓN, Braulio Fabián Terán ,  GARCĺA GUZMÁN, José Alexander ,  ROMERO, Gustavo, Enrique Anaya ,  YEPEZ, Ivan, Dario Romero

IPC: A61J3/07 ,  A61K9/54 ,  A61K45/06 ,  A61K45/08

Abstract: The invention provides a rotary die mold process for manufacturing softgel capsules incorporating another solid form within said capsule and wherein said softgel capsule is free of air bubbles, in which at least two material strips are brought together by means of counter-running forming rolls and formed into capsules, a liquid and solid filling material being introduced via a filling wedge segment comprising two concave wedge surfaces; a filling medicine inlet; a fill medicine outlet; an output of solids and pre-fill medicine; a solids feed channel and pre-fill medicine; a pre-filling medicine inlet and a solids inlet. A softgel capsule free of air bubbles having incorporated within said capsule a second solid form, said second solid form being the form of a tablet.

公开(公告)号：WO2012017325A3

公开(公告)日：2012-05-10

申请号：PCT/IB2011002443

申请日：2011-07-18

Applicant: PROCAPS SA ,  ALTAMAR CARLOS SALAZAR ,  ANAYA GUSTAVO ,  TERAN BRAULIO ,  NAVARRO NEWMAN AGUAS ,  HERRERA WILMER

Inventor： ALTAMAR CARLOS SALAZAR ,  ANAYA GUSTAVO ,  TERAN BRAULIO ,  NAVARRO NEWMAN AGUAS ,  HERRERA WILMER

IPC: A61J3/07 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/22 ,  A61K9/48 ,  A61K9/51 ,  A61K31/00

CPC classification number: A61J3/07 ,  A61K9/4808 ,  A61K9/4833

Abstract: The invention provides an apparatus for producing soft gel capsules having encapsulated therein microparticles, nanoparticles and fluids, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies; (d) a liquid fill system (medicine pump system); (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) one or more microgranule or nanogranule feeders located on each side of the rotary dies, said feeders being synchronized to rotate at the same tangential speed as the rotary dies.

Abstract translation: 本发明提供了一种用于生产软胶囊的装置，其中封装有微粒，纳米颗粒和流体，所述装置包括：（a）两个扩张箱; （b）两个铸桶; （c）一对旋转模具; （d）液体填充系统（药物泵系统）; （e）用于加热明胶带并进料所述填充物的楔子; 和（f）位于旋转模具的每一侧上的一个或多个微粒或纳米颗粒进料器，所述进料器同步以与旋转模具相同的切向速度旋转。