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公开(公告)号：WO2023021175A1
公开(公告)日：2023-02-23
申请号：PCT/EP2022/073153
申请日：2022-08-19
申请人： SISSA - SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI , AZIENDA SANITARIA UNIVERSITARIA FRIULI CENTRALE , UNIVERSITA' DEGLI STUDI DI UDINE
IPC分类号： A61K31/138 , A61K31/175 , A61K31/195 , A61K31/196 , A61K31/407 , A61K31/44 , A61K45/06 , A61P35/00
摘要： The present invention refers to a composition comprising R-Ketorolac, Bumetadine, at least one Cl- channels blocker and, optionally, Infliximab for use in the treatment of low- and high-grade glioma.
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公开(公告)号：WO2023275004A1
公开(公告)日：2023-01-05
申请号：PCT/EP2022/067657
申请日：2022-06-28
IPC分类号： A61K9/00 , A61K9/06 , A61K9/107 , A61K31/196 , A61K47/18 , A61K47/34 , A61P19/02 , A61P21/00 , A61P29/00 , A61K9/08 , A61K47/186 , A61K9/0014 , A61K9/1075
摘要： There is disclosed a nano-complex composition for topical drug delivery, comprising a diclofenac alkali metal salt, a cationic surfactant, glycol, or glycol ether or glycol ether ester, C2 to C3 alcohol, and water. The composition can further comprise hyaluronic acid. There is also provided a method of manufacture of nano-complex compositions for topical drug delivery. The compositions of the disclosure are useful in the treatment of joint pain, osteoarthritis, muscle pain, back pain and/or inflammation.
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公开(公告)号：WO2022167402A1
公开(公告)日：2022-08-11
申请号：PCT/EP2022/052307
申请日：2022-02-01
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ CLAUDE BERNARD - LYON 1 , ECOLE NORMALE SUPÉRIEURE DE LYON
IPC分类号： A61K31/437 , A61P35/00 , A61P37/00 , A61K31/196 , A61K31/277 , A61K31/42 , A61K31/444 , A61K31/47 , A61K31/53 , A61K31/4196 , A61K31/44 , A61K31/4439 , A61K45/06
摘要： The nucleosides availability is a crucial factor governing the proliferation of any living entities (viruses, bacteria, parasites or eukaryotic cells). The enzyme involved in the fourth step of the de novo pyrimidine nucleotides biosynthetic pathway, where L-dihydroorotate (DHO) is converted to orotate (ORO), is named dihydroorotate dehydrogenase (DHODH). This enzyme has been recognized as a promising target for the treatment of autoimmune diseases, cancers and infections. However, there is a still a need for identifying new synergic combinations with DHODH inhibitors. The inventors show synergistic effect of DHODH inhibitors and IDH inhibitors on the proliferation of cancer cell lines. The present invention thus relates to methods of therapy comprising administering a therapeutically effective combination comprising a DHODH inhibitor and an IDH inhibitor.
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公开(公告)号：WO2022114138A1
公开(公告)日：2022-06-02
申请号：PCT/JP2021/043424
申请日：2021-11-26
申请人： 大正製薬株式会社
IPC分类号： C07C227/26 , A61K31/196 , A61P9/10 , A61P21/02 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07C69/34 , C07C69/757 , C07C229/50 , C07C235/40 , C07C235/82 , C07C255/47 , C07C309/66 , C07C309/73 , C07C313/06 , C07D303/40
摘要： （１Ｒ，２Ｒ，３Ｒ，５Ｒ，６Ｒ）－２－アミノ－６－フルオロ－３－［（４－フルオロフェニル）メトキシ］ビシクロ［３．１．０］ヘキサン－２，６－ジカルボン酸の新規な製造方法を提供し、この製造方法は、 式（３）で表される化合物からの変換によることを特徴とする。
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公开(公告)号：WO2022093134A1
公开(公告)日：2022-05-05
申请号：PCT/TR2020/050992
申请日：2020-10-26
发明人： SANCAK, Abdulhaluk , ONUK GOREN, Ayse Figen , ANSARI, Azmatullah , GURPINAR, Hakan , GOKDENIZ, Yasemin , SEZGIN, Asiye , VARINCA YILDIZ, Seyma , YILMAZ, Koray
IPC分类号： A61K31/196 , A61K9/28 , A61K47/26
摘要： The present invention relates to the preparation of pharmaceutical compositions comprising diclofenac potassium and also relevant excipients; in the treatment of pain and inflammatory diseases, having an improved manufacturing process by using sugar based film coating systems.
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公开(公告)号：WO2022081799A1
公开(公告)日：2022-04-21
申请号：PCT/US2021/054907
申请日：2021-10-14
发明人： BEDIAN, Vahe , HARWIN, Peter , KISELAK, Tomas , SHE, Angela , VIOLIN, Jonathan , ZHAO, Yang
IPC分类号： A61K31/138 , A61K31/196 , A61K31/28 , A61K31/282 , A61K31/337
摘要： Antibodies and compositions against IGF-1R and uses thereof are provided herein.
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公开(公告)号：WO2022065404A1
公开(公告)日：2022-03-31
申请号：PCT/JP2021/034972
申请日：2021-09-24
申请人： アステラス製薬株式会社
IPC分类号： A61K47/38 , A61K9/06 , A61K9/08 , A61K31/167 , A61K31/196 , A61K31/4422 , A61K38/18 , A61K45/00 , A61P27/16 , C07K14/485
摘要： 容易に耳内投与でき、かつ、耳内で薬物を滞留及び徐放する機能を有する医薬組成物を提供する。薬物１種又は２種以上及び水分散性微細セルロース組成物、特に結晶セルロース・カルメロースナトリウムを含有する、耳内投与用の医薬組成物。
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公开(公告)号：WO2022022483A1
公开(公告)日：2022-02-03
申请号：PCT/CN2021/108541
申请日：2021-07-27
申请人： 浙江普洛家园药业有限公司 , 普洛药业股份有限公司 , 杭州普洛药物研究院有限公司
IPC分类号： A61K9/19 , A61K31/196 , A61P25/00 , A61P9/10
摘要： 一种索法地尔冻干粉针剂，及其制备方法和用途。本发明的制备方法包括下列步骤：将索法地尔加入到注射用水中，溶清后过滤，滤液用碱性物质水溶液调节pH值，再加入注射用水定容，充入惰性气体保护，除菌过滤后得到索法地尔溶液，冻干，即得。
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公开(公告)号：WO2022003585A1
公开(公告)日：2022-01-06
申请号：PCT/IB2021/055856
申请日：2021-06-30
申请人： HETERO HEALTHCARE LIMITED , MALE, Srinivas Reddy , DOHE, Ganesh Haridas , KAKATI, Imran Ibrahim , PAWAR, Shantaram Laxman
IPC分类号： A61K31/00 , A61K9/70 , A61K31/196
摘要： The present invention relates to transdermal patch composition comprising active ingredient having anti-inflammatory, analgesic and antipyretic activities. The present invention specifically relates to transdermal patch composition comprising Diclofenac as active ingredient, high concentration of hot melt pressure sensitive adhesive, low concentration of tackifier and pharmaceutically acceptable excipients. The present invention also relates to process for the preparation of Diclofenac diethylamine transdermal patch by using hot-melt coating technique (HMC) comprising the steps of melting, mixing, coating, laminating and cutting.
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公开(公告)号：WO2021252054A1
公开(公告)日：2021-12-16
申请号：PCT/US2021/025754
申请日：2021-04-05
申请人： OCULAR SCIENCE, INC.
IPC分类号： A61K31/196 , A61K9/00 , A61K9/08 , A61K31/4709 , A61K31/573 , A61P27/02 , A61P29/00 , A61P31/04 , A61K47/02 , A61K9/0048
摘要： Provided herein are certain preservative-free ophthalmic formulations for post-operative ocular care.
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