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    ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS
    1.
    发明申请
    ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS 审中-公开
    使用珠子或其他捕获物体对分子或颗粒进行超敏感检测

    公开(公告)号：WO2011109364A2

    公开(公告)日：2011-09-09

    申请号：PCT/US2011026645

    申请日：2011-03-01

    Applicant: QUANTERIX CORP ,  DUFFY DAVID C ,  RISSIN DAVID M ,  WALT DAVID R ,  FOURNIER DAVID ,  KAN CHEUK

    Inventor： DUFFY DAVID C ,  RISSIN DAVID M ,  WALT DAVID R ,  FOURNIER DAVID ,  KAN CHEUK

    IPC: G01N33/50 ,  C12Q1/68

    CPC classification number: G01N33/54393 ,  G01N33/54306 ,  G01N33/54313

    Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.

    Abstract translation: 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括相对于多个捕获物体固定多个分析物分子或颗粒。 多个捕获对象的至少一部分可以在空间上分离成多个位置。 可以至少部分地确定包含相对于捕获对象固定的分析物分子的反应容器的数量，来测量流体样品中分析物分子的浓度。 在一些情况下，该测定可另外包括包括结合配体，前体标记试剂和/或酶组分的步骤。

    ULTRA-SENSITIVE DETECTION OF MOLECULES USING DUAL DETECTION METHODS
    5.
    发明申请
    ULTRA-SENSITIVE DETECTION OF MOLECULES USING DUAL DETECTION METHODS 审中-公开
    超灵敏检测分子的双重检测方法

    公开(公告)号：WO2011109372A8

    公开(公告)日：2011-11-10

    申请号：PCT/US2011026657

    申请日：2011-03-01

    Applicant: QUANTERIX CORP ,  DUFFY DAVID C ,  RISSIN DAVID M ,  WALT DAVID R ,  SONG LINAN ,  CHANG LEI

    Inventor： DUFFY DAVID C ,  RISSIN DAVID M ,  WALT DAVID R ,  SONG LINAN ,  CHANG LEI

    IPC: G01N33/543

    CPC classification number: G01N33/54393 ,  G01N33/5306

    Abstract: Described herein are systems and methods for the detection of and/or determination of a measure of the concentration of analyte molecules or particles in a fluid sample. In some cases, the systems and methods employ techniques to reduce or limit the negative effects associated with non-specific binding events. Certain methods of the present invention involve associating the analyte molecules at least a first type of binding ligand and at least a second type of binding ligand, and spatially segregating the analyte molecules into a plurality of locations on a surface. The presence of an analyte molecule at or in a location may be determined by determining the presence of both the first type of binding ligand and the second type of binding ligand.

    Abstract translation: 本文描述了用于检测和/或确定流体样品中的分析物分子或颗粒浓度的量度的系统和方法。 在一些情况下，系统和方法采用技术来减少或限制与非特异性结合事件相关的负面影响。 本发明的某些方法涉及将分析物分子与至少第一类型的结合配体和至少第二类型的结合配体缔合，并将分析物分子空间分离成表面上的多个位置。 可以通过确定第一类型结合配体和第二类型结合配体两者的存在来确定分析物分子在位置处或位置处的存在。

    HIGH SENSITIVITY DETERMINATION OF THE CONCENTRATION OF ANALYTE MOLECULES OR PARTICLES IN A FLUID SAMPLE
    6.
    发明申请
    HIGH SENSITIVITY DETERMINATION OF THE CONCENTRATION OF ANALYTE MOLECULES OR PARTICLES IN A FLUID SAMPLE 审中-公开
    高灵敏度测定流体样品中分析物分子或颗粒的浓度

    公开(公告)号：WO2010039180A2

    公开(公告)日：2010-04-08

    申请号：PCT/US2009005250

    申请日：2009-09-22

    Applicant: QUANTERIX CORP ,  DUFFY DAVID C ,  RISSIN DAVID M ,  SONG LINAN ,  WALT DAVID R

    Inventor： DUFFY DAVID C ,  RISSIN DAVID M ,  SONG LINAN ,  WALT DAVID R

    IPC: C12Q1/68 ,  G01N33/543 ,  G01N33/58

    CPC classification number: G01N33/54366

    Abstract: The present invention relates to methods, systems, and kits for detecting, quantifying and/or analyzing a fluid sample comprising molecules or particles at low concentration. In certain embodiments, the methods for detection and/or quantifying analyte molecules in a sample comprise capturing a plurality of analyte molecules on a substrate (e.g., an array comprising a plurality of reaction vessels). The substrate may then be exposed to additional reaction components such as at least one binding ligand. The substrate may additionally be exposed to a precursor labeling agent molecule, wherein the precursor labeling agent molecule, in some cases, is converted to a labeling agent molecule, which may be detected, either directly or indirectly, which determination may be related to the presence of and/or may be employed to quantify the analyte molecules. Although the various aspects of the present invention may use a number of different assay formats, in one embodiment, the assays are conducted in a plurality of reaction vessels defined, at least in part, by the distal ends of fiber optic strands.

    Abstract translation: 本发明涉及用于检测，定量和/或分析包含低浓度分子或颗粒的流体样品的方法，系统和试剂盒。 在某些实施方案中，用于检测和/或定量样品中分析物分子的方法包括在基底（例如，包含多个反应容器的阵列）上捕获多个分析物分子。 然后可将底物暴露于另外的反应组分如至少一种结合配体。 所述底物可另外暴露于前体标记剂分子，其中所述前体标记剂分子在一些情况下被转化成标记剂分子，其可被直接或间接检测到，所述测定可与存在 和/或可以用于量化分析物分子。 尽管本发明的各个方面可以使用许多不同的测定形式，但在一个实施方案中，测定是在多个反应容器中进行的，所述反应容器至少部分地由光纤束的远端限定。

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