公开(公告)号：WO2007143541A2

公开(公告)日：2007-12-13

申请号：PCT/US2007070208

申请日：2007-06-01

Applicant: UNIV MADISON ,  LAWRENCE DAVID J ,  TUCKER W GENE ,  DEVORE THOMAS C ,  COFFMAN GEORGE L ,  RAAB RONALD W ,  TAYLOR GERALD R

Inventor： LAWRENCE DAVID J ,  TUCKER W GENE ,  DEVORE THOMAS C ,  COFFMAN GEORGE L ,  RAAB RONALD W ,  TAYLOR GERALD R

CPC classification number: G01N25/482 ,  G01N25/4873

Abstract: A detector has a thermoelectric sensor and a reactive layer. The thermoelectric sensor is configured to sense heat and to provide an electrical signal based on the sensed heat. The reactive layer is coupled to the thermoelectric sensor and is reactive with an airborne chemical or airborne biological agent of interest. The reaction is exothermic or endothermic. When the airborne agent of interest reacts with the coating, the reaction is detected by the thermoelectric sensor. The electrical signal provides an indication based on the reaction.

Abstract translation: 检测器具有热电传感器和反应层。 热电传感器被配置为感测热量并且基于感测的热量提供电信号。 反应层耦合到热电传感器，并与感兴趣的空气传播的化学或机载生物试剂反应。 反应是放热或吸热。 当感兴趣的空气传播剂与涂层反应时，反应由热电传感器检测。 电信号基于反应提供指示。

公开(公告)号：WO2007143541A3

公开(公告)日：2007-12-13

申请号：PCT/US2007/070208

申请日：2007-06-01

Applicant: JAMES MADISON UNIVERSITY ,  LAWRENCE, David, J. ,  TUCKER, W., Gene ,  DEVORE, Thomas, C. ,  COFFMAN, George, L. ,  RAAB, Ronald, W. ,  TAYLOR, Gerald, R.

Inventor： LAWRENCE, David, J. ,  TUCKER, W., Gene ,  DEVORE, Thomas, C. ,  COFFMAN, George, L. ,  RAAB, Ronald, W. ,  TAYLOR, Gerald, R.

IPC: G01N25/48

Abstract: A detector has a thermoelectric sensor (12) and a reactive layer (50). The thermoelectric sensor is configured to sense heat and to provide an electrical signal based on the sensed heat. The reactive layer is coupled to the thermoelectric sensor and is reactive with an airborne chemical or airborne biological agent of interest. The reaction is exothermic or endothermic. When the airborne agent of interest reacts with the coating, the reaction is detected by the thermoelectric sensor. The electrical signal provides an indication based on the reaction.

公开(公告)号：WO1993002108A1

公开(公告)日：1993-02-04

申请号：PCT/US1992006194

申请日：1992-07-24

Applicant: IDEC PHARMACEUTICALS CORPORATION ,  NEWMAN, Roland, A. ,  HANNA, Nabil ,  RAAB, Ronald, W.

Inventor： IDEC PHARMACEUTICALS CORPORATION

IPC: C07K15/28

CPC classification number: C07K16/18 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/28 ,  C07K16/2812 ,  C07K16/2821 ,  C07K16/461 ,  C07K16/462 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2319/02

Abstract: Chimeric antibodies including an Old World monkey portion and a human portion, nucleic acid encoding such antibodies, Old World monkey monoclonal antibodies, and methods for their production and use.

Abstract translation: 包括老世界猴部分和人部分的嵌合抗体，编码这种抗体的核酸，老世界猴单克隆抗体及其生产和使用方法。

公开(公告)号：WO2008033477A2

公开(公告)日：2008-03-20

申请号：PCT/US2007019957

申请日：2007-09-13

Applicant: UNIV VIRGINIA ,  UNIV MADISON ,  MCKOWN ROBERT L ,  RAAB RONALD W ,  LAURIE GORDON W

Inventor： MCKOWN ROBERT L ,  RAAB RONALD W ,  LAURIE GORDON W

IPC: A61K9/70

CPC classification number: A61K38/18 ,  A61K2300/00

Abstract: The present invention provides recombinant proteins with antimicrobial activity and methods for treating animals including humans by administering the novel recombinant proteins. In particular, the invention provides methods for treating and/or preventing microbial diseases and infections using lacritin and homologs, fragments, modifications, and derivatives thereof.

Abstract translation: 本发明提供具有抗微生物活性的重组蛋白质和通过施用新的重组蛋白质来治疗包括人的动物的方法。 特别地，本发明提供了使用lacritin及其同系物，片段，修饰和衍生物治疗和/或预防微生物疾病和感染的方法。

公开(公告)号：WO2008033477A3

公开(公告)日：2008-03-20

申请号：PCT/US2007/019957

申请日：2007-09-13

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION ,  JAMES MADISON UNIVERSITY ,  MCKOWN, Robert, L. ,  RAAB, Ronald, W. ,  LAURIE, Gordon, W.

Inventor： MCKOWN, Robert, L. ,  RAAB, Ronald, W. ,  LAURIE, Gordon, W.

IPC: C12P21/06

Abstract: The present invention provides recombinant proteins with antimicrobial activity and methods for treating animals including humans by administering the novel recombinant proteins. In particular, the invention provides methods for treating and/or preventing microbial diseases and infections using lacritin and homologs, fragments, modifications, and derivatives thereof.