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    METHOD FOR DETERMINING THE CONCENTRATION OF OXYGEN
    3.
    发明申请
    METHOD FOR DETERMINING THE CONCENTRATION OF OXYGEN 审中-公开
    测定氧浓度的方法

    公开(公告)号：WO1989004476A1

    公开(公告)日：1989-05-18

    申请号：PCT/DK1988000181

    申请日：1988-11-03

    Applicant: RADIOMETER A/S

    Inventor： RADIOMETER A/S ,  JENSEN, Niels, Henrik

    IPC: G01N21/64

    CPC classification number: G01N21/62 ,  G01N2021/6482

    Abstract: The concentration of molecular oxygen in a sample is determined by exciting oxygen molecules of the sample from the electronic ground state to the excited DELTA g state (excited singlet state), measuring a 1270-nm luminescence characteristic of the excited oxygen molecules (singlet oxygen) and correlating the luminescence characteristic measured with the concentration of molecular oxygen in the sample. Normally, the 1270-nm luminescence characteristic is the 1270-nm luminescence intensity. Preferably, the oxygen molecules are excited by being subjected to diffusion contact with a sensitizer such as a porphyrin or a porphyrin-related compound, e.g. a transition metal complex of a porphyrin. The sensitizer is brought into an oxygen-exciting electronic state by absorption of electromagnetic radiation such as light, the oxygen-exciting electronic state optionally being adapted to the measuring system employed by means of a quencher such as a substituted polyene. The sensitizer may be present in an organic solvent or a polymer such as polyvinylchloride. The oxygen-containing sample is preferably a sample of biological origin such as a blood sample.

    Abstract translation: 样品中分子氧的浓度通过将样品从电子基态氧化分子激发到激发态（激发单态）来测定激发的氧分子的1270nm发光特性来确定（ 单重态氧），并将测量的发光特性与样品中分子氧浓度相关联。 通常，1270nm发光特性是1270nm发光强度。 优选地，氧分子通过与敏化剂例如卟啉或卟啉相关化合物例如与卟啉相互扩散接触来激发。 卟啉的过渡金属络合物。 通过吸收诸如光的电磁辐射将敏化剂引入氧激发电子状态，氧激发电子状态任选地适合于通过诸如取代多烯的猝灭剂使用的测量系统。 敏化剂可以存在于有机溶剂或聚合物如聚氯乙烯中。 含氧样品优选为生物来源的样品，例如血液样品。

    A METHOD AND A SYSTEM FOR THE IN VIVO DETERMINATION OF AN ELECTRICAL POTENTIAL DIFFERENCE
    4.
    发明申请
    A METHOD AND A SYSTEM FOR THE IN VIVO DETERMINATION OF AN ELECTRICAL POTENTIAL DIFFERENCE 审中-公开
    一种用于确定电位差异的方法和系统

    公开(公告)号：WO1988006860A1

    公开(公告)日：1988-09-22

    申请号：PCT/DK1988000043

    申请日：1988-03-11

    Applicant: RADIOMETER A/S

    Inventor： RADIOMETER A/S ,  HOJGAARD, Liselotte ,  SAKSAGER, Kim ,  KRAG, Einer ,  ANDERSEN, Jens, Rikardt ,  LINNET, Niels, Dürkopp ,  OLSEN, Frank, Nygaard

    IPC: A61B05/04

    CPC classification number: A61B5/14542 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/4238

    Abstract: The in vivo determination of an electrical potential difference across a human or animal membrane of a fluid-containing cavity, such as the stomach (200), is performed by arranging (e.g. via an endoscope (201)) a measuring half cell (20) (electrode and electrolyte) in its entirety within the cavity and in contact with the cavity fluid, and arranging a reference half cell (50) in contact with a human or animal fluid outside the cavity, typically the blood, suitably via a catheter (87). The concentration of a species such as a H concentration in gastric juice contributing significantly to a liquid junction potential between the measuring electrolyte and the cavity fluid is measured, preferably by means of a sensor such as a pH sensor (110), preferably arranged within the cavity, and a relevant correction of the potential difference measured is based on said concentration measurement.

    Abstract translation: 通过布置（例如经由内窥镜（201））测量半电池（20）来执行穿过诸如胃（200）的流体容纳腔的人或动物膜之间的电势差的体内测定， （电极和电解质）整体在空腔内并与空腔流体接触，并且通过导管（87）适当地布置参考半电池（50）与空腔外的人或动物流体（通常为血液）接触 ）。 优选地，通过诸如pH传感器（110）的传感器，优选地测量在测量电解质和腔体流体之间显着影响液体接合电位的胃液中的H ++浓度物质的浓度，优选地 排列在空腔内，并且所测量的电位差的相关校正基于所述浓度测量。

    ION-SENSITIVE MEASURING ELECTRODE DEVICE
    5.
    发明申请
    ION-SENSITIVE MEASURING ELECTRODE DEVICE 审中-公开
    离子敏感测量电极器件

    公开(公告)号：WO1984001829A1

    公开(公告)日：1984-05-10

    申请号：PCT/DK1983000101

    申请日：1983-10-31

    Applicant: RADIOMETER A/S ,  ENGELL, John, Emil ,  MORTENSEN, Svend

    Inventor： RADIOMETER A/S

    IPC: G01N27/30

    CPC classification number: C04B35/447 ,  C04B35/16 ,  C04B35/481 ,  C04B35/624 ,  C04B35/62655 ,  C04B2235/3201 ,  C04B2235/3217 ,  C04B2235/3244 ,  C04B2235/3418 ,  C04B2235/3427 ,  C04B2235/441 ,  C04B2235/447 ,  C04B2235/5409 ,  C04B2235/77 ,  C04B2235/80 ,  C04B2235/81 ,  G01N27/333 ,  H01M6/185

    Abstract: An ion-sensitive measuring electrode device with an ion-sensitive element based on ion-conducting crystalline ceramic material. The electrode device shows a selectivity to the Na ion versus the H ion corresponding to the selectivity of the known sodium-sensitive glass-based solid membrane electrodes. Ion-sensitive measuring electrode devices showing good selectivity properties are provided on the basis of ion-conducting crystalline material, the crystal structure of which comprises a three-dimensionally extending interstitial space containing positions for the ion, especially material in which the interstitial space has bottlenecks which just permits passage of the ion. A method for preparing polycrystalline ceramic material based on oxides of zirconium, phosphor and silicon is also provided.

    Abstract translation: 一种离子敏感测量电极装置，其具有基于离子导电结晶陶瓷材料的离子敏感元件。 对于已知的钠敏感的玻璃基固体膜电极的选择性，电极装置显示对Na +离子相对于H +离子的选择性。 显示出良好选择性的离子敏感测量电极器件是基于离子导电晶体材料提供的，离子导电晶体材料的晶体结构包括三维延伸的间隙空间，其包含用于离子的位置，特别是间隙空间具有瓶颈的材料 这只允许离子通过。 还提供了一种基于锆，磷和硅的氧化物制备多晶陶瓷材料的方法。

    METHOD OF PHOTOMETRIC IN VITRO DETERMINATION OF THE CONTENT OF AN ANALYTE IN A SAMPLE
    6.
    发明申请
    METHOD OF PHOTOMETRIC IN VITRO DETERMINATION OF THE CONTENT OF AN ANALYTE IN A SAMPLE 审中-公开
    方法测定样品中分析物含量的方法

    公开(公告)号：WO1993006456A1

    公开(公告)日：1993-04-01

    申请号：PCT/DK1992000280

    申请日：1992-09-17

    Applicant: RADIOMETER A/S ,  FRISCHAUF, Peter, Aage

    Inventor： RADIOMETER A/S

    IPC: G01N21/03

    CPC classification number: G01N21/0303 ,  G01N21/314 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3129 ,  G01N2035/1062 ,  G01N2201/0662

    Abstract: The present method is a method of photometric in vitro determination of the content of an analyte in a sample. The sample is located in a measuring chamber device with a measuring chamber, which has a defined radiation path length and has at least one at least partially transparent wall part. The measuring chamber is in optical communication with an optical system adapted for the analyte and comprising a radiation source and a radiation detector. Further, the measuring chamber is adjustable in shape thereby controlling the setting of the radiation path length across the measuring chamber. In a first measuring step a first radiation path length across the measuring chamber is set and radiation at at least one wavelength is transmitted from the radiation source through the measuring chamber and to the radiation detector. Then in a second step the measuring chamber is adjusted in shape thereby setting a second wavelength across the measuring chamber. Radiation at the same wavelength as during the first step is again transmitted from the radiation source through the measuring chamber and to the radiation detector. The analyte content is then determined on the basis of radiation detected in each of the measuring steps.

    Abstract translation: 本方法是一种光度测定样品中分析物含量的方法。 样品位于具有测量室的测量室装置中，该测量室具有限定的辐射路径长度并且具有至少一个至少部分透明的壁部分。 测量室与适于分析物的光学系统光学通信，并且包括辐射源和辐射探测器。 此外，测量室的形状是可调节的，从而控制跨越测量室的辐射路径长度的设定。 在第一测量步骤中，设置横跨测量室的第一辐射路径长度，并且至少一个波长的辐射从辐射源通过测量室和辐射探测器传输。 然后在第二步骤中，测量室被调节成形状，从而在测量室上设置第二波长。 与第一步骤相同波长的辐射再次从辐射源通过测量室和辐射探测器传输。 然后基于在每个测量步骤中检测到的辐射来确定分析物含​​量。

    METHOD OF MONITORING THE POSITION OF A SENSOR
    7.
    发明申请
    METHOD OF MONITORING THE POSITION OF A SENSOR 审中-公开
    监测传感器位置的方法

    公开(公告)号：WO1992012670A1

    公开(公告)日：1992-08-06

    申请号：PCT/DK1992000014

    申请日：1992-01-21

    Applicant: RADIOMETER A/S ,  KROGH, Soren-Christian ,  AKSBRO, Erik

    Inventor： RADIOMETER A/S

    IPC: A61B05/06

    CPC classification number: A61B5/1477 ,  A61B5/062 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1491

    Abstract: When performing the method a sensor (1) is used with a coil (15) integrated in a coil circuit. In the coil circuit a magnetic field is generated so that mutual induction can develop between the coil circuit and the surroundings of the sensor (1). The magnetic field in the coil circuit is detected intermittently, and a developed mutual induction is detected as a change of the magnetic field. The position of the sensor is monitored on the basis of said intermittent detection of the magnetic field in the coil circuit. The change of the magnetic field in the coil circuit can be detected in several ways. If the magnetic field is varying, the change may for example be detected as a change of the peak value of the voltage across or the current intensity through the coil circuit or be detected as a phase shift of one of these parameters. The method is used especially to ensure that calibration of the sensor (1) is performed only when the sensor (1) is located in a related calibration chamber (24). The detectable mutual induction is developed between the coil circuit with the coil (15) and an aluminum cup (22) constituting the calibration chamber (24).

    Abstract translation: 当执行该方法时，传感器（1）与集成在线圈电路中的线圈（15）一起使用。 在线圈电路中产生磁场，使得线圈电路和传感器（1）周围之间可以产生互感。 线圈电路中的磁场被间歇地检测，并且显影的互感被检测为磁场的变化。 基于线圈电路中的所述磁场的间歇检测来监测传感器的位置。 线圈电路中的磁场变化可以用几种方法来检测。 如果磁场发生变化，则该变化例如可以被检测为通过线圈电路的电压峰值或电流强度的变化，或者被检测为这些参数之一的相移。 该方法特别用于确保仅当传感器（1）位于相关校准室（24）中时才执行传感器（1）的校准。 在与线圈（15）的线圈电路和构成校准室（24）的铝杯（22）之间形成可检测的互感。

    A METHOD AND AN APPARATUS FOR POTENTIOMETRIC DETERMINATION OF A CONCENTRATION OF AN ION OR A DISSOLVED GAS
    8.
    发明申请
    A METHOD AND AN APPARATUS FOR POTENTIOMETRIC DETERMINATION OF A CONCENTRATION OF AN ION OR A DISSOLVED GAS 审中-公开
    用于电位浓度测定离子浓度或溶解气体的方法和装置

    公开(公告)号：WO1992022811A1

    公开(公告)日：1992-12-23

    申请号：PCT/DK1992000179

    申请日：1992-06-10

    Applicant: RADIOMETER A/S ,  FOMBON, Jean-Jacques

    Inventor： RADIOMETER A/S

    IPC: G01N27/416

    CPC classification number: G01N27/4165

    Abstract: A method for calibration of a potentiometric sensor comprising: selection of at least three calibration solutions all containing a well-known different concentration (C1, C2, C3, ...Cn) of the ion or the dissolved gas and at least one of the calibration solutions having a concentration which according to the response equation falls between the lower linearity limit point (P1) and the sensitivity limit point (P2), measurement of the potential (E1, E2, E3, ...En) of each of these solutions, insertion of these values of potential and concentration into the theoretical response equation for the sensor Ei = E'0 + S . log (Ci + C0), determination of the values of the unknowns E'0, S and C0, and determination of the response equation for the sensor by inserting the unknown values into the theoretical equation.

    GLASS ELECTRODE
    9.
    发明申请
    GLASS ELECTRODE 审中-公开
    玻璃电极

    公开(公告)号：WO1991012523A1

    公开(公告)日：1991-08-22

    申请号：PCT/DK1991000031

    申请日：1991-02-04

    Applicant: RADIOMETER A/S ,  ROED, Gjerloff ,  LINNET, Niels, Dürkopp

    Inventor： RADIOMETER A/S

    IPC: G01N27/36

    CPC classification number: G01N27/36

    Abstract: The glass electrode comprises a membrane of ion sensitive glass. The membrane comprises a composite material consisting of a matrix of ion sensitive glass and a dispersed filling material therein having higher tensile strength than the matrix. The membrane of the glass electrode is particularly resistant to mechanical stress and the glass electrode is i.a. applicable in a tc Pco2 electrode of the Severinghaus-type.

    Abstract translation: 玻璃电极包括离子敏感玻璃的膜。 膜包括由离子敏感玻璃基质和其中分散的填充材料组成的复合材料，其具有比基体更高的拉伸强度。 玻璃电极的膜特别耐机械应力，玻璃电极是i.a. 适用于Severinghaus型的tc Pco2电极。

    CALIBRATION DEVICE FOR USE IN CALIBRATING A SENSOR
    10.
    发明申请
    CALIBRATION DEVICE FOR USE IN CALIBRATING A SENSOR 审中-公开
    用于校准传感器的校准装置

    公开(公告)号：WO1990001160A1

    公开(公告)日：1990-02-08

    申请号：PCT/DK1989000092

    申请日：1989-04-20

    Applicant: RADIOMETER A/S ,  HANSEN, Steffen, Thomas ,  SORENSEN, Poul, Ravn

    Inventor： RADIOMETER A/S

    IPC: G01N27/26

    CPC classification number: G01N27/4163 ,  Y10T436/10

    Abstract: In one embodiment the calibration device (1) comprises a housing (2) which by means of a removable lid (8) and a rupturable barrier layer (3) is divided into a calibration chamber (4) and a second chamber (10). Calibration chamber (4) contains a calibration fluid (5) - e.g. a dry gas - while second chamber (10) contains a second fluid (11) - e.g. a wetting agent. Immediately prior to a calibration process the lid (8) is removed, whereafter the sensor in question with its measuring surface in front is inserted through the second chamber (10) into the housing (2) until abutment against a shoulder (6) in said housing (2). This causes the barrier layer (3) to rupture and the second fluid (11) to contact the calibration fluid (5). Hereafter the calibration process can take place. In another embodiment the device (1) further comprises a membrane (12) which is accommodated in the second chamber (10) and is adapted to be secured to the sensor during the insertion of same into the housing (2). The disclosed device - which is particularly suited for use in calibrating sensors for transcutaneous registering of the contents of CO2 and/or O2 in blood - is self-contained, and can be made of a very compact design, making it very well suited for use in connection with portable equipment. Further the device is suitable for being manufactured in the form of a disposable unit.

    Abstract translation: 在一个实施例中，校准装置（1）包括通过可移除的盖（8）并且可破裂的阻挡层（3）被分成校准室（4）和第二室（10）的壳体（2）。 校准室（4）包含校准流体（5）。 干燥气体 - 而第二室（10）包含第二流体（11）。 润湿剂。 在校准过程之前，立即除去盖（8），此后将其前面的测量表面所涉及的传感器通过第二腔室（10）插入壳体（2）中，直到与所述第二腔室（6）中的肩部 住房（2）。 这导致阻挡层（3）破裂并且第二流体（11）接触校准流体（5）。 以后可以进行校准过程。 在另一个实施例中，装置（1）还包括容纳在第二室（10）中的膜（12），并且适于在将其插入壳体（2）期间固定到传感器。 所公开的装置 - 特别适合用于校准用于血液中二氧化碳和/或氧气的内容物的经皮注射的传感器 - 是独立的，并且可以由非常紧凑的设计制成，使其非常适合于使用 与便携式设备有关。 此外，该装置适于以一次性单元的形式制造。

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