公开(公告)号：WO2014186517A1

公开(公告)日：2014-11-20

申请号：PCT/US2014/038090

申请日：2014-05-15

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  SARPESHKAR, Rahul ,  MULDAVIN, Jeremy, B. ,  THORSEN, Todd, A. ,  KEDZIERSKI, Jakub ,  RAPOPORT, Benjamin, I. ,  FEE, Michale, S.

Inventor： SARPESHKAR, Rahul ,  MULDAVIN, Jeremy, B. ,  THORSEN, Todd, A. ,  KEDZIERSKI, Jakub ,  RAPOPORT, Benjamin, I. ,  FEE, Michale, S.

IPC: A61N1/378 ,  H01M8/10 ,  H01M4/86 ,  H01M4/90 ,  H01M4/92 ,  H01M4/98 ,  H01M8/00

CPC classification number: H01M4/8652 ,  A61B5/14532 ,  A61B5/686 ,  A61N1/3785 ,  H01M4/8626 ,  H01M4/8663 ,  H01M4/8867 ,  H01M4/8882 ,  H01M4/90 ,  H01M4/921 ,  H01M4/98 ,  H01M8/004 ,  H01M8/0208 ,  H01M8/1009 ,  H01M8/1039 ,  H01M8/1076 ,  H01M8/1081 ,  H01M8/1097 ,  H01M2008/1095 ,  Y02P70/56

Abstract: A glucose fuel cell for reception into a given constrained volume of implantation in a vertebrate in which the glucose fuel cell has access to fluid containing glucose. The fuel cell includes an anode adapted to oxidize the glucose, a cathode adapted to reduce an oxidant, and a membrane disposed between the anode and the cathode and separating the anode from the cathode. At least one of the anode or cathode define a flexible sheet that is geometrically deformed to be receivable into the given constrained volume of implantation and increase volumetric power density. Related methods of making a glucose fuel cell of this type and implantable assemblies including the glucose fuel cell are also disclosed.

Abstract translation: 一种葡萄糖燃料电池，用于接收在脊椎动物中给定的约束体积的植入物，其中葡萄糖燃料电池可以进入含有葡萄糖的流体。 燃料电池包括适于氧化葡萄糖的阳极，适于减少氧化剂的阴极和设置在阳极和阴极之间并将阳极与阴极分离的膜。 阳极或阴极中的至少一个限定几何变形的柔性片，以可接收到给定的约束体积的注入并增加体积功率密度。 还公开了制造这种葡萄糖燃料电池和包括葡萄糖燃料电池的可植入组件的相关方法。

公开(公告)号：WO2008148092A1

公开(公告)日：2008-12-04

申请号：PCT/US2008/064882

申请日：2008-05-27

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  RAPOPORT, Benjamin, I. ,  SARPESHKAR, Rahul ,  WATTANAPANITCH, Woradorn

Inventor： RAPOPORT, Benjamin, I. ,  SARPESHKAR, Rahul ,  WATTANAPANITCH, Woradorn

IPC: A61B5/04 ,  G06F3/01

CPC classification number: A61B5/04001 ,  G06F3/015 ,  G06K9/00536

Abstract: A microchip for performing a neural decoding algorithm is provided. The microchip is implemented using ultra-low power electronics. Also, the microchip includes a tunable neural decodable filter implemented using a plurality of amplifiers, a plurality of parameter learning filters, a multiplier, a gain and time-constant biasing circuits; and analog memory. The microchip, in a training mode, learns to perform an optimized translation of a raw neural signal received from a population of cortical neurons into motor control parameters. The optimization being based on a modified gradient descent least square algorithm wherein update for a given parameter in a filter is proportional to an averaged product of an error in the final output that the filter affects and a filtered version of its input. The microchip, in an operational mode, issues commands to controlling a device using learned mappings.

Abstract translation: 提供了一种用于执行神经解码算法的微芯片。 微芯片采用超低功耗电子器件实现。 此外，微芯片包括使用多个放大器实现的可调谐神经可解码滤波器，多个参数学习滤波器，乘法器，增益和时间常数偏置电路; 和模拟记忆。 在训练模式下，微芯片学习了将从皮质神经元群体接收的原始神经信号转化为电动机控制参数的优化翻译。 该优化基于修正的梯度下降最小二乘算法，其中过滤器中的给定参数的更新与滤波器影响的最终输出中的误差和其输入的滤波版本的平均乘积成比例。 在操作模式下，微芯片发出使用学习映射控制设备的命令。

公开(公告)号：WO2020185975A1

公开(公告)日：2020-09-17

申请号：PCT/US2020/022202

申请日：2020-03-11

Applicant: RAPOPORT, Benjamin, I. ,  PATSALIDES, Athos

Inventor： RAPOPORT, Benjamin, I. ,  PATSALIDES, Athos

IPC: A61N1/05 ,  A61B5/0478

Abstract: Described herein are systems and methods for deploying and recording electrophysiologic signals from electrode arrays located within the dura mater of the brain. The dura matter includes layers of connective tissue, or membrane, that surround the brain and spinal cord. The present disclosure relates to an endovascular electrode system deployed within the blood vessels located between layers of the dura mater, including, for example, the middle meningeal artery and its branches.

公开(公告)号：WO2020185972A1

公开(公告)日：2020-09-17

申请号：PCT/US2020/022199

申请日：2020-03-11

Applicant: RAPOPORT, Benjamin, I. ,  PATSALIDES, Athos

Inventor： RAPOPORT, Benjamin, I. ,  PATSALIDES, Athos

IPC: A61B5/0476 ,  A61N1/05

Abstract: The present disclosure is directed to systems and methods for endovascular electroencephalography (EEG) and el ectrocorti cography (ECoG) systems. In some embodiments, the disclosed systems include electrode arrays that are configured to record and/or stimulate brain tissue via placement within blood vessels of the brain. Venous and arterial EEG and ECoG electrodes, ambulatory EEG and ECoG systems, and transcutaneous access and signal control systems for general and ambulatory endovascular electroencephalography (EEG) and electrocorticography (ECoG), as well as endovascular neural stimulating electrodes are discussed.

公开(公告)号：WO2008148097A3

公开(公告)日：2009-02-19

申请号：PCT/US2008064893

申请日：2008-05-27

Applicant: MASSACHUSETTS INST TECHNOLOGY ,  SARPESHKAR RAHUL ,  RAPOPORT BENJAMIN I ,  WATTANAPANITCH WORADOM ,  MANDAL SOUMYAJIT ,  ARFIN SCOTT

Inventor： SARPESHKAR RAHUL ,  RAPOPORT BENJAMIN I ,  WATTANAPANITCH WORADOM ,  MANDAL SOUMYAJIT ,  ARFIN SCOTT

IPC: A61B5/04 ,  A61B5/0476 ,  A61F2/72 ,  A61N1/36 ,  A61N1/372 ,  G06F3/01 ,  H03F1/02 ,  H03F1/26 ,  H03F3/45

CPC classification number: G06F1/32 ,  A61B5/0031 ,  A61B5/04001 ,  A61B5/7232 ,  A61F2/72 ,  A61N1/3605 ,  A61N1/3727 ,  A61N1/37276 ,  G06F3/015 ,  H03F3/2176 ,  H03F3/45192

Abstract: An ultra-low-power circuit for wireless neural recording and stimulation is provided. The circuit includes a neural amplifier with adaptive power biasing for use in multi-electrode arrays and a decoding and/or learning architecture. An impedance- modulation telemetry system provides low-power data telemetry. Also, the circuit includes a wireless link for efficient power transfer, and at least one circuit for wireless stimulation of neurons.

Abstract translation: 提供了一种用于无线神经记录和刺激的超低功率电路。 该电路包括具有用于多电极阵列的自适应功率偏置的神经放大器以及解码和/或学习架构。 阻抗调制遥测系统提供低功耗数据遥测。 此外，电路包括用于有效功率传输的无线链路，以及用于神经元的无线刺激的至少一个电路。

公开(公告)号：WO2008148097A2

公开(公告)日：2008-12-04

申请号：PCT/US2008/064893

申请日：2008-05-27

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  SARPESHKAR, Rahul ,  RAPOPORT, Benjamin, I. ,  WATTANAPANITCH, Woradom ,  MANDAL, Soumyajit ,  ARFIN, Scott

Inventor： SARPESHKAR, Rahul ,  RAPOPORT, Benjamin, I. ,  WATTANAPANITCH, Woradom ,  MANDAL, Soumyajit ,  ARFIN, Scott

IPC: A61B5/04 ,  A61B5/0476

CPC classification number: G06F1/32 ,  A61B5/0031 ,  A61B5/04001 ,  A61B5/7232 ,  A61F2/72 ,  A61N1/3605 ,  A61N1/3727 ,  A61N1/37276 ,  G06F3/015 ,  H03F3/2176 ,  H03F3/45192

Abstract: An ultra-low-power circuit for wireless neural recording and stimulation is provided. The circuit includes a neural amplifier with adaptive power biasing for use in multi-electrode arrays and a decoding and/or learning architecture. An impedance- modulation telemetry system provides low-power data telemetry. Also, the circuit includes a wireless link for efficient power transfer, and at least one circuit for wireless stimulation of neurons.

Abstract translation: 提供了一种用于无线神经记录和刺激的超低功率电路。 该电路包括具有用于多电极阵列的自适应功率偏置的神经放大器以及解码和/或学习架构。 阻抗调制遥测系统提供低功耗数据遥测。 此外，电路包括用于有效功率传输的无线链路，以及用于神经元的无线刺激的至少一个电路。

公开(公告)号：WO2008148094A1

公开(公告)日：2008-12-04

申请号：PCT/US2008/064885

申请日：2008-05-27

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  SARPESHKAR, Rahul ,  RAPOPORT, Benjamin, I. ,  WATTANAPANITCH, Woradorn

Inventor： SARPESHKAR, Rahul ,  RAPOPORT, Benjamin, I. ,  WATTANAPANITCH, Woradorn

IPC: H03F1/02 ,  H03F1/26 ,  H03F3/45

CPC classification number: H03F1/0266 ,  H03F1/26 ,  H03F3/45192

Abstract: A micropower neural amplifier with adaptive power biasing for use in multi- electrode arrays is provided. The micropower neural amplifier includes a low noise gain stage. The low noise gain stage is implemented using an amplifier and pseudoresistor elements.

Abstract translation: 提供了一种用于多电极阵列的具有自适应功率偏置的微功率神经放大器。 微功率神经放大器包括低噪声增益级。 低噪声增益级使用放大器和伪电阻元件实现。