公开(公告)号：WO2006028525A3

公开(公告)日：2007-05-18

申请号：PCT/US2005014846

申请日：2005-04-29

Applicant: NEREUS PHARMACEUTICALS INC ,  POTTS BARBARA CHRISTINE ,  MACHERLA VENKATA RAMI REDDY ,  MITCHELL SCOTT SHERMAN ,  MANAM RAMA RAO ,  REED KATHERINE ANNE ,  LAM KIN SING ,  NEUTEBOOM SASKIA THEODORA CORN ,  CHAO TA-HSIANG ,  NICHOLSON BENJAMIN ,  BILLSTROM CHERYL

Inventor： POTTS BARBARA CHRISTINE ,  MACHERLA VENKATA RAMI REDDY ,  MITCHELL SCOTT SHERMAN ,  MANAM RAMA RAO ,  REED KATHERINE ANNE ,  LAM KIN SING ,  NEUTEBOOM SASKIA THEODORA CORN ,  CHAO TA-HSIANG ,  NICHOLSON BENJAMIN ,  BILLSTROM CHERYL

IPC: C07D491/04 ,  A61K31/407 ,  C07D207/12 ,  C07D207/28 ,  C07D491/02 ,  C07F5/02

CPC classification number: C07D491/04 ,  C07D207/28 ,  C07F5/025

Abstract: Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

Abstract translation: 具有抗癌，抗炎和抗微生物性质的式I-VI及其衍生物的化合物和包含一种或多种具有抗癌，抗炎和抗微生物的化合物及其衍生物或类似物的组合物 属性被公开。 还公开了包含这些化合物的药物组合物和用所公开的化合物或所公开的药物组合物治疗癌症，炎性病症和微生物感染的方法。

公开(公告)号：WO2006028525A2

公开(公告)日：2006-03-16

申请号：PCT/US2005/014846

申请日：2005-04-29

Applicant: NEREUS PHARMACEUTICALS, INC. ,  POTTS, Barbara, Christine ,  MACHERLA, Venkata, Rami, Reddy ,  MITCHELL, Scott, Sherman ,  MANAM, Rama, Rao ,  REED, Katherine, Anne ,  LAM, Kin, Sing ,  NEUTEBOOM, Saskia, Theodora, Cornelia ,  CHAO, Ta-Hsiang ,  NICHOLSON, Benjamin ,  BILLSTROM, Cheryl

Inventor： POTTS, Barbara, Christine ,  MACHERLA, Venkata, Rami, Reddy ,  MITCHELL, Scott, Sherman ,  MANAM, Rama, Rao ,  REED, Katherine, Anne ,  LAM, Kin, Sing ,  NEUTEBOOM, Saskia, Theodora, Cornelia ,  CHAO, Ta-Hsiang ,  NICHOLSON, Benjamin ,  BILLSTROM, Cheryl

IPC: A61K31/407 ,  C07D207/28 ,  C07D491/02 ,  C07D491/04

CPC classification number: C07D491/04 ,  C07D207/28 ,  C07F5/025

Abstract: Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

Abstract translation: 具有抗癌，抗炎和抗微生物性质的式I-VI及其衍生物的化合物和包含一种或多种具有抗癌，抗炎和抗微生物的化合物及其衍生物或类似物的组合物 属性被公开。 还公开了包含这些化合物的药物组合物和用所公开的化合物或所公开的药物组合物治疗癌症，炎性病症和微生物感染的方法。

公开(公告)号：WO2005070922A2

公开(公告)日：2005-08-04

申请号：PCT/US2005/002039

申请日：2005-01-21

Applicant: NEREUS PHARMACEUTICALS, INC. ,  MITCHELL, Scott, S. ,  LAM, Kin, S. ,  POTTS, Barbara, C. ,  TSUENG, Ginger ,  GRODBERG, Jennifer ,  WHITE, Donald, J. ,  REED, Katherine, Anne

Inventor： MITCHELL, Scott, S. ,  LAM, Kin, S. ,  POTTS, Barbara, C. ,  TSUENG, Ginger ,  GRODBERG, Jennifer ,  WHITE, Donald, J. ,  REED, Katherine, Anne

IPC: C07D403/00

CPC classification number: C07H19/00 ,  C07D403/00 ,  C07D403/14

Abstract: Compounds of Formula (I), commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

Abstract translation: 通常称为双吲哚吡咯的式（I）化合物，包括分离的天然存在的化合物，其具有抗微生物性质的合成和半合成衍生物，以及包含一种或多种 双吲哚吡咯及其衍生物或具有抗微生物性质的类似物。 还公开了包含这些化合物的药物组合物和用所公开的化合物或公开的药物组合物治疗细菌感染的方法。

公开(公告)号：WO2005070922A3

公开(公告)日：2005-09-09

申请号：PCT/US2005002039

申请日：2005-01-21

Applicant: NEREUS PHARMACEUTICALS INC ,  MITCHELL SCOTT S ,  LAM KIN S ,  POTTS BARBARA C ,  TSUENG GINGER ,  GRODBERG JENNIFER ,  WHITE DONALD J ,  REED KATHERINE ANNE

Inventor： MITCHELL SCOTT S ,  LAM KIN S ,  POTTS BARBARA C ,  TSUENG GINGER ,  GRODBERG JENNIFER ,  WHITE DONALD J ,  REED KATHERINE ANNE

IPC: A61K31/405 ,  A61K31/655 ,  C07D403/14 ,  C07D403/00 ,  A61K31/401 ,  A61K31/404 ,  A61P31/04

CPC classification number: C07H19/00 ,  C07D403/00 ,  C07D403/14

Abstract: Compounds of Formula (I), commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

Abstract translation: 通常称为双吲哚吡咯的化合物，包括分离的天然存在的化合物，其具有抗微生物性质的合成和半合成衍生物以及包含一种或多种双吲哚吡咯及其衍生物的抗微生物组合物 或具有抗微生物性质的类似物。 还公开了包含这些化合物的药物组合物和用所公开的化合物或所公开的药物组合物治疗细菌感染的方法。