公开(公告)号：WO2006091669A1

公开(公告)日：2006-08-31

申请号：PCT/US2006/006278

申请日：2006-02-22

Applicant: NEREUS PHARMACEUTICALS, INC. ,  MACHERLA, Venkata, Rami, Reddy ,  NICHOLSON, Benjamin ,  LAM, Kin, Sing

Inventor： MACHERLA, Venkata, Rami, Reddy ,  NICHOLSON, Benjamin ,  LAM, Kin, Sing

IPC: C07D263/40 ,  C07C257/06 ,  A61K31/421 ,  A61K31/19 ,  A61P35/00 ,  A61P31/14 ,  C12P17/14 ,  C12P13/00

CPC classification number: C07D263/40 ,  C07C257/06 ,  C12P17/14

Abstract: Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.

Abstract translation: 本文公开了各种新的恶唑烷酮，咪唑啉酮和噻唑烷酮类似物以及使用这些类似物治疗癌症和/或微生物感染的方法。 特定的4-恶唑烷酮化合物显示具有抗癌和抗微生物活性。

公开(公告)号：WO2007030662A1

公开(公告)日：2007-03-15

申请号：PCT/US2006/034930

申请日：2006-09-08

Applicant: NEREUS PHARMACEUTICALS, INC. ,  LAM, Kin Sing ,  PALLADINO, Michael

Inventor： LAM, Kin Sing ,  PALLADINO, Michael

IPC: C12P17/18

CPC classification number: C12P17/18

Abstract: Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve, for example, genetic manipulation, selection of reagents in the fermentation feedstock, and selection of fermentation conditions.

Abstract translation: 公开了调节Salinosporamide A及其类似物的生物合成的方法，其可用于治疗癌症，炎性病症和/或感染性疾病。 所述方法涉及例如遗传操作，发酵原料中的试剂选择以及发酵条件的选择。

公开(公告)号：WO2007120801A3

公开(公告)日：2008-02-14

申请号：PCT/US2007009084

申请日：2007-04-12

Applicant: NEREUS PHARMACEUTICALS INC ,  READER SARAH LOUISE ,  KENNEDY MAX JAMES ,  HINKLEY SIMON FRANCIS ROBERT ,  LAM KIN SING

Inventor： READER SARAH LOUISE ,  KENNEDY MAX JAMES ,  HINKLEY SIMON FRANCIS ROBERT ,  LAM KIN SING

IPC: C12N1/10 ,  C12N1/12

CPC classification number: C12N1/00

Abstract: Methods of saline fermentation are provided. A fermenter vessel is charged with a fermentation medium having less than about 300 ppm chloride ions, which is then sterilized. A sterile chloride salt solution is added to the medium to produce a saline fermentation medium. The saline fermentation medium is then inoculated with a microorganism and the saline fermentation medium is cultured under conditions suitable for the growth of the microorganism. Finally, the medium can be harvested.

Abstract translation: 提供盐水发酵方法。 向发酵罐中加入具有少于约300ppm氯离子的发酵培养基，然后将其灭菌。 将无菌氯化物盐溶液加入到培养基中以产生盐水发酵培养基。 然后用微生物接种盐水发酵培养基，并在适于生长微生物的条件下培养生理盐水发酵培养基。 最后，可以收获培养基。

公开(公告)号：WO2007120801A2

公开(公告)日：2007-10-25

申请号：PCT/US2007/009084

申请日：2007-04-12

Applicant: NEREUS PHARMACEUTICALS, INC. ,  READER, Sarah Louise ,  KENNEDY, Max James ,  HINKLEY, Simon Francis Robert ,  LAM, Kin Sing

Inventor： READER, Sarah Louise ,  KENNEDY, Max James ,  HINKLEY, Simon Francis Robert ,  LAM, Kin Sing

CPC classification number: C12N1/00

Abstract: Methods of saline fermentation are provided. A fermenter vessel is charged with a fermentation medium having less than about 300 ppm chloride ions, which is then sterilized. A sterile chloride salt solution is added to the medium to produce a saline fermentation medium. The saline fermentation medium is then inoculated with a microorganism and the saline fermentation medium is cultured under conditions suitable for the growth of the microorganism. Finally, the medium can be harvested.

Abstract translation: 提供盐水发酵方法。 向发酵罐中加入具有少于约300ppm氯离子的发酵培养基，然后将其灭菌。 将无菌氯化物盐溶液加入到培养基中以产生盐水发酵培养基。 然后用微生物接种盐水发酵培养基，并在适于生长微生物的条件下培养生理盐水发酵培养基。 最后，可以收获培养基。

公开(公告)号：WO2006028525A3

公开(公告)日：2007-05-18

申请号：PCT/US2005014846

申请日：2005-04-29

Applicant: NEREUS PHARMACEUTICALS INC ,  POTTS BARBARA CHRISTINE ,  MACHERLA VENKATA RAMI REDDY ,  MITCHELL SCOTT SHERMAN ,  MANAM RAMA RAO ,  REED KATHERINE ANNE ,  LAM KIN SING ,  NEUTEBOOM SASKIA THEODORA CORN ,  CHAO TA-HSIANG ,  NICHOLSON BENJAMIN ,  BILLSTROM CHERYL

Inventor： POTTS BARBARA CHRISTINE ,  MACHERLA VENKATA RAMI REDDY ,  MITCHELL SCOTT SHERMAN ,  MANAM RAMA RAO ,  REED KATHERINE ANNE ,  LAM KIN SING ,  NEUTEBOOM SASKIA THEODORA CORN ,  CHAO TA-HSIANG ,  NICHOLSON BENJAMIN ,  BILLSTROM CHERYL

IPC: C07D491/04 ,  A61K31/407 ,  C07D207/12 ,  C07D207/28 ,  C07D491/02 ,  C07F5/02

CPC classification number: C07D491/04 ,  C07D207/28 ,  C07F5/025

Abstract: Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

Abstract translation: 具有抗癌，抗炎和抗微生物性质的式I-VI及其衍生物的化合物和包含一种或多种具有抗癌，抗炎和抗微生物的化合物及其衍生物或类似物的组合物 属性被公开。 还公开了包含这些化合物的药物组合物和用所公开的化合物或所公开的药物组合物治疗癌症，炎性病症和微生物感染的方法。

公开(公告)号：WO2006028525A2

公开(公告)日：2006-03-16

申请号：PCT/US2005/014846

申请日：2005-04-29

Applicant: NEREUS PHARMACEUTICALS, INC. ,  POTTS, Barbara, Christine ,  MACHERLA, Venkata, Rami, Reddy ,  MITCHELL, Scott, Sherman ,  MANAM, Rama, Rao ,  REED, Katherine, Anne ,  LAM, Kin, Sing ,  NEUTEBOOM, Saskia, Theodora, Cornelia ,  CHAO, Ta-Hsiang ,  NICHOLSON, Benjamin ,  BILLSTROM, Cheryl

Inventor： POTTS, Barbara, Christine ,  MACHERLA, Venkata, Rami, Reddy ,  MITCHELL, Scott, Sherman ,  MANAM, Rama, Rao ,  REED, Katherine, Anne ,  LAM, Kin, Sing ,  NEUTEBOOM, Saskia, Theodora, Cornelia ,  CHAO, Ta-Hsiang ,  NICHOLSON, Benjamin ,  BILLSTROM, Cheryl

IPC: A61K31/407 ,  C07D207/28 ,  C07D491/02 ,  C07D491/04

CPC classification number: C07D491/04 ,  C07D207/28 ,  C07F5/025

Abstract: Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

Abstract translation: 具有抗癌，抗炎和抗微生物性质的式I-VI及其衍生物的化合物和包含一种或多种具有抗癌，抗炎和抗微生物的化合物及其衍生物或类似物的组合物 属性被公开。 还公开了包含这些化合物的药物组合物和用所公开的化合物或所公开的药物组合物治疗癌症，炎性病症和微生物感染的方法。