公开(公告)号：WO0224623A2

公开(公告)日：2002-03-28

申请号：PCT/GB0104226

申请日：2001-09-21

Applicant: GLAXO GROUP LTD ,  LOOKER BRIAN EDGAR ,  REDGRAVE ALISON JUDITH ,  LUNNISS CHRISTOPHER JAMES ,  REYNOLDS DEREK PETER

Inventor： LOOKER BRIAN EDGAR ,  REDGRAVE ALISON JUDITH ,  LUNNISS CHRISTOPHER JAMES ,  REYNOLDS DEREK PETER

IPC: A61K9/12 ,  A61K47/06 ,  A61K47/32 ,  A61P11/00 ,  C07C51/09 ,  C07C51/367 ,  C07C59/125 ,  C07C59/135 ,  C07C69/708 ,  C07C31/18 ,  C07C31/42 ,  C07C67/333 ,  C07C69/34

CPC classification number: C07C69/708 ,  C07C51/09 ,  C07C59/125 ,  C07C59/135 ,  Y10S514/958

Abstract: There are provided according to the invention compounds of the formula (I) or a salt or solvate thereof, wherein: n represents an integer 1 to 6; N represents an integer 1 to 15; R represents (CO)xC1-9alkyl or (CO)xC1-9fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms wherein x represents 0 or 1; and R and R independently represent C1-3alkyl or hydrogen. There are also provided pharmaceutical aerosol formulations employing said compounds as suspension stabilising agents.

Abstract translation: 根据本发明提供式（I）化合物或其盐或溶剂化物，其中：n表示1至6的整数; N表示1〜15的整数， R 1表示（CO）x C 1-9烷基或（CO）x C 1-9氟烷基，该氟烷基部分含有至少1个氟原子和不多于3个连续的全氟化碳原子，其中x表示0或1; R 2和R 3独立地表示C 1-3烷基或氢。 还提供了使用所述化合物作为悬浮稳定剂的药物气溶胶制剂。

公开(公告)号：WO2002024623A3

公开(公告)日：2002-03-28

申请号：PCT/GB2001/004226

申请日：2001-09-21

Applicant: GLAXO GROUP LIMITED ,  LOOKER, Brian, Edgar ,  REDGRAVE, Alison, Judith ,  LUNNISS, Christopher, James ,  REYNOLDS, Derek, Peter

Inventor： LOOKER, Brian, Edgar ,  REDGRAVE, Alison, Judith ,  LUNNISS, Christopher, James ,  REYNOLDS, Derek, Peter

IPC: C07C51/09

Abstract: There are provided according to the invention compounds of the formula (I) or a salt or solvate thereof, wherein: n represents an integer 1 to 6; N represents an integer 1 to 15; R 1 represents (CO) x C 1-9 alkyl or (CO) x C 1-9 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms wherein x represents 0 or 1; and R 2 and R 3 independently represent C 1-3 alkyl or hydrogen. There are also provided pharmaceutical aerosol formulations employing said compounds as suspension stabilising agents.