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    CARBOXYLIC ACID COMPOUNDS FOR USE AS SURFACTANTS
    1.
    发明申请
    CARBOXYLIC ACID COMPOUNDS FOR USE AS SURFACTANTS 审中-公开
    用作表面活性剂的羧酸化合物

    公开(公告)号：WO2003068722A1

    公开(公告)日：2003-08-21

    申请号：PCT/GB2003/000547

    申请日：2003-02-12

    Applicant: GLAXO GROUP LIMITED ,  LOOKER, Brian, Edgar ,  LUNNISS, Christopher, James ,  REDGRAVE, Alison

    Inventor： LOOKER, Brian, Edgar ,  LUNNISS, Christopher, James ,  REDGRAVE, Alison

    IPC: C07C69/63

    CPC classification number: A61K8/60 ,  A61K8/8111 ,  A61K8/922 ,  A61K9/008 ,  A61K47/12 ,  A61Q9/04 ,  C07C69/63

    Abstract: The invention relates to compounds of formula (I) or a salt or solvate thereof, wherein: x represents 0 or 1; y represents 0 or 1; R 1 and R 2 independently represent -C 1-9 alkyleneC 1-6 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms and wherein said R 1 and/or R 2 moiety is optionally interrupted by an ether link, processes for their preparation, use of said compounds in the preparation of pharmaceutical aerosol formulations and said formulations.

    Abstract translation: 本发明涉及式（I）化合物或其盐或溶剂合物，其中：x表示0或1; y表示0或1; R1和R2独立地表示-C1-9亚烷基C1-6氟代烷基，该氟烷基部分含有至少1个氟原子和不多于3个连续的全氟化碳原子，并且其中所述R 1和/或R 2部分任选地被醚键中断， 它们的制备，所述化合物在制备药物气雾剂配制剂和所述制剂中的用途。

    COMPOUNDS FOR USE AS SURFACTANTS
    7.
    发明申请
    COMPOUNDS FOR USE AS SURFACTANTS 审中-公开
    用作表面活性剂的化合物

    公开(公告)号：WO2003035237A2

    公开(公告)日：2003-05-01

    申请号：PCT/EP2002/011635

    申请日：2002-10-17

    Applicant: GLAXO GROUP LIMITED ,  LOOKER, Brian, Edgar ,  LUNNISS, Christopher, James ,  REDGRAVE, Alison, Judith

    Inventor： LOOKER, Brian, Edgar ,  LUNNISS, Christopher, James ,  REDGRAVE, Alison, Judith

    IPC: B01F17/00

    CPC classification number: A61K9/008 ,  B01F17/0028 ,  B01F17/0035

    Abstract: There are provided according to the invention compounds of formula (I) or salts or solvate thereof, wherein:n and N independently represent an integer 2 to 12;m1 and m2 independently represent an integer 1 to 15; and R1 and R2 independently represent -(CO)xC1-9 alkyl or -(CO)xC1-9 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms wherein x represents 0 or 1. The invention includes uses of said compounds and processes for their preparation.

    Abstract translation: 根据本发明提供了式（I）的化合物或其盐或溶剂合物，其中：n和N独立地表示2至12的整数; m 1和m 2独立地表示1至15的整数 ; 并且R 1和R 2独立地表示 - （CO）x C 1-9烷基或 - （CO）x C 1-9氟代烷基，其中氟代烷基部分含有至少1个氟原子和不多于3个连续的全氟化碳原子，其中x代表0或1。 包括所述化合物的用途及其制备方法。

    SURFACTANT COMPOUNDS AND USES THEREOF
    8.
    发明申请
    SURFACTANT COMPOUNDS AND USES THEREOF 审中-公开

    公开(公告)号：WO2003013610A3

    公开(公告)日：2003-02-20

    申请号：PCT/GB2002/003586

    申请日：2002-08-02

    Applicant: GLAXO GROUP LIMITED ,  KALDOR, Istvan ,  LOOKER, Brian, Edgar ,  LUNNISS, Christopher, James ,  REDGRAVE, Alison, Judith

    Inventor： KALDOR, Istvan ,  LOOKER, Brian, Edgar ,  LUNNISS, Christopher, James ,  REDGRAVE, Alison, Judith

    IPC: A61K9/12

    Abstract: A pharmaceutical aerosol formulation comprising a particulate medicament, one or more fluorocarbon or hydrogen-containing fluorocarbon propellants and a compound of the general formula (I) or a salt or solvate thereof, wherein A represents a straight chain C 1 - 16 alkylene substituted by n groups of formula B; n represents an integer 1 to 3; and B independently represents C 1 - 4 fluoroalkylC 0 - 6 alkylene-, C 1 - 4 fluoroalkylC 0 - 6 alkylene-O-, or C 1 - 4 alkylC 0 - 6 alkylene-O- wherein at least one substituent of formula B contains at least one fluorine atom and each C 1 - 4 fluoroalkyl- moiety contains one or more fluorine atoms but not more than 3 consecutive perfluorinated carbon atoms. The invention also extends to uses of compounds of formula (I) and certain novel compounds within the definition of formula (I).

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