公开(公告)号：WO2021195494A2

公开(公告)日：2021-09-30

申请号：PCT/US2021/024354

申请日：2021-03-26

Applicant: ASKLEPIOS BIOPHARMACEUTICAL, INC. ,  SYNPROMICS LTD ,  WHYTESIDE, Graham ,  ROBERTS, Michael L.

Inventor： TORRANCE, Victoria Fiona

IPC: C12N15/86 ,  C12N15/864 ,  C12N5/10 ,  C12N2750/14143 ,  C12N2750/14152 ,  C12N2830/002

Abstract: Aspects described herein relate to stable cell line for recombinant viral vector (e.g., recombinant adeno associated viral vector) production comprising at least one inducible promoter operatively linked to a heterologous gene that encodes a toxic protein. Methods for making stable cell lines, and methods for viral vector production are further provided herein.

公开(公告)号：WO2010125360A1

公开(公告)日：2010-11-04

申请号：PCT/GB2010/000880

申请日：2010-04-30

Applicant: IMPERIAL INNOVATIONS LIMITED ,  HENG, Jerry ,  ROBERTS, Michael, Mark ,  WILLIAMS, Daryl

Inventor： HENG, Jerry ,  ROBERTS, Michael, Mark ,  WILLIAMS, Daryl

IPC: C07K1/30 ,  C07K1/14

CPC classification number: C07K1/306

Abstract: A method and apparatus for producing crystalline protein particles. A protein solution is re-circulated from a reservoir container (1) using a pump (2), through one or more capillaries (3) and back to the reservoir (1) through a re-circulation loop (5) and an outlet (6). In the capillary zone the solution is treated such that the protein solubility decreases, causing the protein to precipitate.

Abstract translation: 一种生产结晶蛋白颗粒的方法和装置。 使用泵（2），通过一个或多个毛细管（3）从储存器容器（1）再循环蛋白质溶液并通过再循环回路（5）和出口（5）返回储存器（1） 6）。 在毛细管区域中处理溶液使得蛋白质溶解度降低，导致蛋白质沉淀。

公开(公告)号：WO2008131588A1

公开(公告)日：2008-11-06

申请号：PCT/CN2007/001427

申请日：2007-04-28

Applicant: HUAWEI TECHNOLOGIES CO., LTD. ,  QVARFORDT, Christer ,  OLOFSSON, Henrik ,  SANDBERG, David ,  JOHANSSON, Johan ,  ROBERTS, Michael

Inventor： QVARFORDT, Christer ,  OLOFSSON, Henrik ,  SANDBERG, David ,  JOHANSSON, Johan ,  ROBERTS, Michael

IPC: H04Q7/30

CPC classification number: H04W48/08 ,  H04J11/0093 ,  H04W16/32 ,  H04W84/105

Abstract: The invention relates to a method for transmission mode change in a telecommunication network, said network having a public network comprising at least one public base station (NB) covering a public cell and a private network comprising at least one private base station (PBS) covering a private cell, wherein said at least one private base station has limited access rights for User Equipment (UE:s) in the private network, and where said UE:s are able to also communicate with the public network, comprising the step of: performing a private base station transmission mode change when the private base station is in an interference reduction transmission mode to an active transmission mode when an UE with access rights to said private base station is detected in proximity of said private base station, where a detection of said proximity is based on information being specific for said UE and its relation to said private base station. The invention also relates to a telecommunication network.

Abstract translation: 本发明涉及一种用于电信网络中的传输模式改变的方法，所述网络具有包括覆盖公共小区的至少一个公共基站（NB）和包括至少一个专用基站（PBS）的专用网络的公共网络的公共网络，所述专用网络覆盖 私有小区，其中所述至少一个专用基站对所述专用网络中的用户设备（UE）具有有限的访问权限，并且所述UE还能够与所述公共网络通信，所述方法包括以下步骤： 当在所述专用基站附近检测到具有对所述专用基站的访问权限的UE时，当专用基站处于干扰减少传输模式时，执行专用基站传输模式改变为主动传输模式，其中检测 所述接近度基于针对所述UE的特定信息及其与所述专用基站的关系。 本发明还涉及电信网络。

公开(公告)号：WO2008082892A3

公开(公告)日：2008-09-25

申请号：PCT/US2007087293

申请日：2007-12-12

Applicant: SANDISK CORP ,  MORGANSTERN MICHAEL ALAN ,  NIIZAWA DEREK ,  SALAZAR JEFFREY A ,  SUNG JUNGGI ,  SIMMONS MICHAEL L ,  MEUNIOT ARTURO ,  ROBERTS MICHAEL S

Inventor： MORGANSTERN MICHAEL ALAN ,  NIIZAWA DEREK ,  SALAZAR JEFFREY A ,  SUNG JUNGGI ,  SIMMONS MICHAEL L ,  MEUNIOT ARTURO ,  ROBERTS MICHAEL S

IPC: H05K5/02

CPC classification number: H05K5/0278 ,  H01R13/447 ,  H01R13/60

Abstract: A hand held electronic device, such as a flash memory drive, includes a mechanism for extending and withdrawing a connector, such as a USB plug, that is adapted for engaging a mating connector of a host device. A positive latch holds the connector with respect to an outer shell when in the extended and withdrawn positions. Movement of a separate housing portion unlatches the connector and outer shell, and also provides movement of the connector. A protective door closes over a connector opening when the connector is withdrawn into the device, and the door is withdrawn into the device when the connector is extended, thereby not interfering with the extended connector.

Abstract translation: 诸如闪存驱动器之类的手持式电子设备包括用于延伸和抽出适于接合主机设备的配合连接器的连接器（例如USB插头）的机构。 当处于伸出位置和缩回位置时，正锁闩相对于外壳保持连接器。 单独壳体部分的移动使连接器和外壳解锁，并且还提供连接器的移动。 当连接器收回到设备中时，防护门关闭在连接器开口上，并且当连接器伸出时，门被拉回到设备中，从而不干扰扩展连接器。

公开(公告)号：WO2008092303A1

公开(公告)日：2008-08-07

申请号：PCT/CN2007/000314

申请日：2007-01-29

Applicant: HUAWEI TECHNOLOGIES CO., LTD. ,  ROBERTS, Michael

Inventor： ROBERTS, Michael

IPC: H04L12/56

CPC classification number: H04W72/042 ,  H04L1/18 ,  H04L47/10

Abstract: A transmitting method in a wireless communication system includes: assembling a plurality of first data units into a second data unit on a data channel, each of the plurality of first data units being destined for a corresponding one of a plurality of receivers respectively; allocating a plurality of first control channels, each of the plurality of first control channels corresponding to one of the plurality of receivers respectively, and including an identity of the corresponding receiver; transmitting each of the p rlurality of first control channels; and transmitting the second data unit through the data channel, association information between each of the plurality of first data units and the corresponding receiver is carried by the corresponding first control channel or by the second data unit so as to allow each of the plurality of receivers to extract the corresponding first data unit from the second data unit. Also, a receiving method, a transmitter and a receiver in the wireless communication system are provided correspondingly.

Abstract translation: 无线通信系统中的发送方法包括：将多个第一数据单元组合成数据信道上的第二数据单元，所述多个第一数据单元中的每一个分别指定给多个接收器中的相应一个; 分配多个第一控制信道，所述多个第一控制信道中的每一个分别对应于所述多个接收机中的一个接收机，并且包括相应接收机的标识; 传输第一控制信道的每一个; 并且通过所述数据信道发送所述第二数据单元，所述多个第一数据单元中的每一个与所述相应接收器之间的关联信息由相应的第一控制信道或所述第二数据单元承载，以便允许所述多个接收器 从第二数据单元提取相应的第一数据单元。 此外，相应地提供无线通信系统中的接收方法，发送机和接收机。

公开(公告)号：WO2008089390A1

公开(公告)日：2008-07-24

申请号：PCT/US2008/051408

申请日：2008-01-18

Applicant: CHELSEA THERAPEUTICS, INC. ,  ROBERTS, Michael, J. ,  PEDDER, Simon

Inventor： ROBERTS, Michael, J. ,  PEDDER, Simon

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D487/04

Abstract: The present invention is directed to antifolate compounds having the structure of formula (I). wherein: X is CHR9 or NR9; Y1, Y2, and Y3 independently are O or S; V1 and V2 independently are O, S, or NZ; Z is H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, or alkaryl; R1 and R2 independently are H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, or alkaryl; R3 is H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, hydroxyl, or halo; and R4, R5, R6, R7, Rs, and R9 independently are H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, acyl, -C(O)-alkyl, - C(O)-alkenyl, or -C(O)-alkynyl; as well as pharmaceutically acceptable esters, amides, salts, solvates, and prodrugs thereof. The compounds are useful in pharmaceutical compositions and in methods of treating multiple conditions, including abnormal cell proliferation, inflammatory diseases, asthma, and arthritis.

Abstract translation: 本发明涉及具有式（I）结构的抗叶酸化合物。 其中：X是CHR 9或NR 9; Y1，Y2和Y3独立地为O或S; V1和V2独立为O，S或NZ; Z是H，任选取代的烷基，任选取代的烯基，任选取代的炔基或烷芳基; R 1和R 2独立地为H，任选取代的烷基，任选取代的烯基，任选取代的炔基或烷芳基; R 3是H，任选取代的烷基，任选取代的烯基，任选取代的炔基，任选取代的烷氧基，羟基或卤素; R 4，R 5，R 6，R 7，R 5和R 9独立地为H，任选取代的烷基，任选取代的烯基，任选取代的炔基，酰基，-C（O） - 烷基，-C（O） - 烯基或-C （O） - 炔基; 以及其药学上可接受的酯，酰胺，盐，溶剂合物和前药。 该化合物可用于药物组合物和治疗多种病症的方法，包括异常细胞增殖，炎性疾病，哮喘和关节炎。

公开(公告)号：WO2008052384A1

公开(公告)日：2008-05-08

申请号：PCT/CN2006/002896

申请日：2006-10-30

Applicant: HUAWEI TECHNOLOGIES CO., LTD. ,  JOHANSSON, Johan ,  ROBERTS, Michael

Inventor： JOHANSSON, Johan ,  ROBERTS, Michael

IPC: H04L12/00

CPC classification number: H04L12/66

Abstract: The invention relates to a method in connection with a multimedia service transmission over a terrestrial wireless network, wherein the multimedia service transmission is sent from a wireless transmitter to at least one single receiver/transmitter user equipment, comprising the steps of: creating in said single receiver/transmitter user equipment, information relevant for said wireless multimedia service transmission, and feeding back said information to a network entity by using a different communications means separate from said terrestrial wireless network, so as to allow an adjustment of the multimedia service transmission in respect of said information, and where the process of feeding back said information is controlled by a network entity. The invention also relates to an user equipment and a network entity.

Abstract translation: 本发明涉及一种与陆地无线网络上的多媒体业务传输有关的方法，其中将多媒体业务传输从无线发射机发送到至少一个单一接收机/发射机用户设备，包括以下步骤：在所述单个 接收机/发射机用户设备，与所述无线多媒体业务传输相关的信息，以及通过使用与所述陆地无线网络分离的不同通信装置将所述信息反馈给网络实体，从而允许相对于多媒体业务传输的调整 所述信息的反馈以及反馈所述信息的过程由网络实体控制。 本发明还涉及用户设备和网络实体。

公开(公告)号：WO2008021964A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/075598

申请日：2007-08-09

Applicant: BLACK & DECKER INC. ,  PHILLIPS, Steven, J. ,  WHITE, Daniel, J. ,  JOHNSON, Alexis, W. ,  ROBERTS, Michael, W.

Inventor： PHILLIPS, Steven, J. ,  WHITE, Daniel, J. ,  JOHNSON, Alexis, W. ,  ROBERTS, Michael, W.

IPC: H01M2/24

CPC classification number: H01M2/105 ,  H01M2/204 ,  H01M10/425 ,  H01M10/482

Abstract: An internal component arrangement within a battery pack housing having multiple cells and adapted for cordless power tools may provide desired mechanical support to constrain the cells. The housing with internal component arrangement is configured to route sensing wires from the cells to an electronics module of the pack.

Abstract translation: 具有多个电池并且适用于无绳电动工具的电池组壳体内的内部部件布置可以提供期望的机械支撑以约束电池。 具有内部组件布置的壳体被配置为将感测线从单元路由到组件的电子模块。

公开(公告)号：WO2007143545A2

公开(公告)日：2007-12-13

申请号：PCT/US2007070216

申请日：2007-06-01

Applicant: ROBARTS RES INST ,  WELLSTAT BIOLOGICS CORP ,  MCFADDEN GRANT ,  WANG FUAN ,  ROBERTS MICHAEL SCOT

Inventor： MCFADDEN GRANT ,  WANG FUAN ,  ROBERTS MICHAEL SCOT

IPC: C12Q1/70

CPC classification number: C12Q1/6883

Abstract: Cells that are deficient in TNF responsiveness are susceptible to infection with a myxoma virus. People infected with myxoma virus infection are treated using an activator of tumor necrosis factor receptor. MT-2 deficient myxoma viruses are useful in treating cancer.

Abstract translation: 缺乏TNF反应性的细胞易感染粘液瘤病毒。 感染粘液瘤病毒感染的人群使用肿瘤坏死因子受体激活剂治疗。 MT-2缺陷型粘液瘤病毒可用于治疗癌症。

公开(公告)号：WO2007126034A1

公开(公告)日：2007-11-08

申请号：PCT/JP2007/059130

申请日：2007-04-20

Applicant: NEC Corporation ,  Ren, Weili ,  Roberts, Michael

Inventor： Ren, Weili ,  Roberts, Michael

IPC: H04J11/00 ,  H04J1/00

CPC classification number: H04L27/2608 ,  H04L5/023 ,  H04L25/0226

Abstract: The present invention provides for a method of controlling selection of a localised scheduling scheme or a distributed scheduling scheme within an OFDMA downlink and including the step of estimating a fading characteristic and initiating switching between the scheduling schemes responsive to the result of the said estimation, wherein the fading characteristic can comprise one of fading rate or fading type, and wherein the invention can provide for such estimating functionality within a mobile radio communications device.

Abstract translation: 本发明提供一种控制在OFDMA下行链路内的局部调度方案或分布式调度方案的选择的方法，包括估计衰落特性并根据所述估计结果启动调度方案之间的切换的步骤，其中 衰落特性可以包括衰落速率或衰落类型之一，并且其中本发明可以提供移动无线电通信设备内的这种估计功能。