中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

25 records (took 0.024 seconds)

    EMBOUT INFÉRIEUR D'ASSEMBLAGE DE COMBUSTIBLE NUCLÉAIRE
    1.
    发明申请
    EMBOUT INFÉRIEUR D'ASSEMBLAGE DE COMBUSTIBLE NUCLÉAIRE 审中-公开
    核燃料组件底部喷嘴

    公开(公告)号：WO2010001033A2

    公开(公告)日：2010-01-07

    申请号：PCT/FR2009/051092

    申请日：2009-06-10

    Applicant: AREVA NP ,  ROBIN, Jean-Pierre

    Inventor： ROBIN, Jean-Pierre

    IPC: G21C3/32 ,  G21C3/30

    CPC classification number: G21C3/3206 ,  G21C3/322 ,  G21C3/3305 ,  G21Y2002/201 ,  G21Y2002/304 ,  G21Y2004/30 ,  Y02E30/38

    Abstract: Cet embout inférieur est du type comprenant une plaque ajourée pour permettre le passage d'eau au travers de celle-ci, l'embout possédant des faces latérales (24), et au moins un élément anti-débris (22) disposé sur une face latérale (24) pour bloquer des débris susceptibles de passer entre l'embout inférieur et un autre embout inférieur adjacent. Selon un aspect de l'invention, à l'état libre, le ou chaque élément anti-débris (22) fait saillie en permanence de la face latérale (24) sur laquelle il est disposé, le ou chaque élément anti-débris (22) étant déformable élastiquement de façon à se rétracter en direction de la face latérale (24) en cas d'effort exercé sur l'élément anti-débris (22) en direction de la face latérale (24).

    Abstract translation: 该底部喷嘴是包括多孔板的类型，以允许水通过它，喷嘴具有侧面（24）和至少一个位于侧面（24）上的防碎屑元件（22），以阻挡碎片 可能在底部喷嘴和另一个相邻的底部喷嘴之间渗透。 根据本发明的一个方面，在自由状态下，所述或每个防碎屑元件（22）从其所在的侧面（24）永久突出，所述或每个防碎屑元件（22）是弹性的 可变形，使得在朝向侧面（24）施加在防碎片元件（22）上的力的情况下，其可以向侧面（24）收缩。

    FLAME DRYER
    2.
    发明申请
    FLAME DRYER 审中-公开
    火焰干燥机

    公开(公告)号：WO2007085617A1

    公开(公告)日：2007-08-02

    申请号：PCT/EP2007/050692

    申请日：2007-01-24

    Applicant: NV BEKAERT SA ,  BEKAERT COMBUSTION TECHNOLOGY B.V. ,  ROBIN, Jean-Pierre ,  LENOIR, Patrick

    Inventor： ROBIN, Jean-Pierre ,  LENOIR, Patrick

    IPC: F26B13/10 ,  D21F5/00 ,  F26B13/22

    CPC classification number: F26B3/305 ,  D21F5/008 ,  F26B13/10 ,  F26B13/22

    Abstract: The object of the invention is an dryer in the dryer section (26) of a machine for treating or producing a web (12). This drying section (26) has, amongst other things, a burner assembly (10), wherein this burner assembly (10) is adapted to produce a flame (14) and exhaust gases (18). Either said flame (14) or the exhaust gases (18) or both are in direct contact with the web (12) to be dried. The flame (14) or the exhaust gases (18) or both cover the maximum width of the web (12) to be dried and this at a temperature exceeding 600°C, e.g. above 700°C, e.g. 800°C, preferably 1000°C and more. By applying such a high temperature to the web (12) to be dried, one achieves a large temperature difference, resulting in a better heat transfer. Considering the theoretical equation of heat transfer q x = k x . A x .DT x ,it is evident that because of the large temperature difference, the dimensions of the system can be reduced and/or the efficiency of the drying process can be refined. A further advantage of the higher energy transfer is that the drying process is accelerated and that the web can pass the dryer at high speeds.

    Abstract translation: 本发明的目的是一种用于处理或生产网（12）的机器的干燥部（26）中的干燥器。 该干燥部分（26）具有燃烧器组件（10），其中该燃烧器组件（10）适于产生火焰（14）和废气（18）。 所述火焰（14）或废气（18）或两者都与要干燥的幅材（12）直接接触。 火焰（14）或废气（18）或两者都覆盖待干燥的幅材（12）的最大宽度，并且在超过600℃的温度下，例如， 高于700℃。 800℃，优选1000℃以上。 通过将这样高的温度施加到要干燥的纤维网（12）上，可以实现较大的温差，导致更好的热传递。 考虑到热传递的理论方程式x x = k x x。 显然，由于温度差大，系统的尺寸可以降低和/或干燥过程的效率可以是 精制。 更高能量转移的另一个优点是加速了干燥过程，并且幅材可以高速地通过干燥器。

    WATER SOLUBLE CRYSTALLIN SALTS OF CERTAIN HARRINGTONINES UNAMBIGUOUSLY PROTONATED ON THEIR ALKALOID NITROGEN AND THEIR USE AS CHEMOTHERAPEUTIC DRUGS
    7.
    发明申请
    WATER SOLUBLE CRYSTALLIN SALTS OF CERTAIN HARRINGTONINES UNAMBIGUOUSLY PROTONATED ON THEIR ALKALOID NITROGEN AND THEIR USE AS CHEMOTHERAPEUTIC DRUGS 审中-公开
    水溶性结晶蛋白钠在其碱性氮化合物上不可预测地使用某些苦参碱，并作为化学药物使用

    公开(公告)号：WO2015101628A1

    公开(公告)日：2015-07-09

    申请号：PCT/EP2014/079456

    申请日：2014-12-30

    Applicant: ROBIN, Jean-Pierre ,  RADOSEVIC, Nina ,  BLANCHARD, Julie ,  ROISNEL, Thierry ,  BATAILLE, Thierry

    Inventor： ROBIN, Jean-Pierre ,  RADOSEVIC, Nina ,  BLANCHARD, Julie ,  ROISNEL, Thierry ,  BATAILLE, Thierry

    IPC: C07D491/14 ,  A61K31/55 ,  A61P35/00

    CPC classification number: C07D491/147 ,  C07D491/14

    Abstract: The present invention concerns harringtonine salts at the solid state exhibiting a protonated nitrogen seen in solid state analysis and having formula (1), comprising solvate, made by reacting a cephalotaxine ester having formula (2), in which R 1 is, but not limited to, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocycloalkyl, and R 2 is, independently, but not limited to H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocycloalkyl, with an acid having general formula AH in a crystallization solvent, wherein the said salt has a water or alkohol solubility ranged approximately from 5 mg/mL to approximately 100 mg/Ml. The invention also related to a process for preparing these salts and their use as chemotherapeutic drugs.

    Abstract translation: 本发明涉及在固态分析中看到的呈质子化氮的固态的哈林顿盐，并且具有式（1），其包含通过使具有式（2）的头孢噻肟酯反应制备的溶剂合物，其中R1是但不限于 烷基，芳基，环烷基，杂烷基，杂芳基或杂环烷基，并且R 2独立地但不限于H，烷基，芳基，环烷基，杂烷基，杂芳基或杂环烷基，与具有通式AH 其中所述盐具有约5mg / mL至约100mg / Ml的水或烷醇溶解度。 本发明还涉及制备这些盐的方法及其作为化学治疗药物的用途。

    PROCESS FOR PREPARING CEPHALOTAXINE ESTERS
    8.
    发明申请
    PROCESS FOR PREPARING CEPHALOTAXINE ESTERS 审中-公开
    制备头孢噻肟酯的方法

    公开(公告)号：WO2010103405A3

    公开(公告)日：2010-11-04

    申请号：PCT/IB2010000835

    申请日：2010-03-11

    Applicant: ROBIN JEAN-PIERRE ,  RADOSEVIC NINA ,  BLANCHARD JULIE

    Inventor： ROBIN JEAN-PIERRE ,  RADOSEVIC NINA ,  BLANCHARD JULIE

    IPC: A61P35/00 ,  C07D491/147

    CPC classification number: C07D491/056 ,  C07D263/44 ,  C07D307/58 ,  C07D307/60 ,  C07D491/147 ,  C07D498/08 ,  C07D498/22

    Abstract: A process for preparing cephalotaxine esters corresponding to the following general formula I which comprises the cephalotaxine backbone: C(R1) (R2) (XH)COO[CTX] wherein CTX represents the cephalotaxine backbone, being optionally substituted and/or dehydrogenated, in which formula I, X is a heteroatom, preferably an oxygen, a sulfur or a nitrogen, R1 and R2, taken separately, may be alkyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, heterocycloalkyl or aralkyl groups, said groups being optionally interrupted by ester functions, or groups that can form one or more rings or a heterocycle together, consisting in bringing the corresponding cephalotaxine compound, or salts, isomers or tautomeric forms thereof, which is free or which is in the form of a metal alkoxide corresponding to the following general formula CTXOM, wherein CTX represents the cephalotaxine backbone, being optionally substituted and/or dehydrogenated, in which M is a hydrogen atom or a metal atom, into contact with a heterocyclic side chain precursor having both a bifunctional protected (bidentate) and activated (acylating) form of an acid bearing a hydrogenated heteroatom, in the alpha (a) position with respect to the carboxyl group, and corresponding to the following general formula: in which case W is a carbon, sulfur, silicon or bore atom, X, R1 and R2 have respectively the same meaning as above, it being possible for R1 and R2 to form a ring or a heterocycle together, and Y and Z are alkyl or heteroalkyl radicals, or monovalent heteroatoms, which may be identical or different, in an independent manner, or may fuse so as to give a divalent heteroatom, it being possible for the X-W bond to be covalent or ionic.

    Abstract translation: 一种制备对应于下列通式I的三尖杉碱酯的方法，该酯包括三尖杉碱主链：C（R1）（R2）（XH）COO [CTX]其中CTX代表任意取代和/或脱氢的三尖杉碱骨架，其中 式I，X为杂原子，优选为氧，硫或氮，R 1和R 2分别为烷基，环烷基，杂烷基，芳基，杂芳基，杂环烷基或芳烷基，所述基团任选被酯官能 ，或可以一起形成一个或多个环或杂环的基团，其中包括使相应的三尖杉碱碱化合物或其盐，异构体或互变异构体形式，其不含游离形式或其形式为对应于以下通用术语的金属醇盐 式CTXOM，其中CTX表示三尖杉碱骨架，其任选地被取代和/或脱氢，其中M为氢原子或金属原子，与hete 在相对于羧基的α（a）位置上具有带有氢化杂原子的酸的双官能保护（二齿）和活化（酰化）形式的双环侧链前体，并且对应于以下通式：其中 情况W是碳，硫，硅或钻孔原子，X，R1和R2分别具有与上述相同的含义，R1和R2可能一起形成环或杂环，并且Y和Z是烷基或杂烷基 基团或单价杂原子，其可以是相同或不同的，可以独立的方式或可以融合以产生二价杂原子，其中XW键可以是共价键或离子键。

    PROCESS FOR PREPARING CEPHALOTAXINE ESTERS
    9.
    发明申请
    PROCESS FOR PREPARING CEPHALOTAXINE ESTERS 审中-公开
    制备西酞菁酯的方法

    公开(公告)号：WO2010103405A2

    公开(公告)日：2010-09-16

    申请号：PCT/IB2010/000835

    申请日：2010-03-11

    Applicant: ROBIN, Jean-Pierre ,  RADOSEVIC, Nina ,  BLANCHARD, Julie

    Inventor： ROBIN, Jean-Pierre ,  RADOSEVIC, Nina ,  BLANCHARD, Julie

    CPC classification number: C07D491/056 ,  C07D263/44 ,  C07D307/58 ,  C07D307/60 ,  C07D491/147 ,  C07D498/08 ,  C07D498/22

    Abstract: A process for preparing cephalotaxine esters corresponding to the following general formula I which comprises the cephalotaxine backbone: C(R 1 ) (R 2 ) (XH)COO[CTX] wherein CTX represents the cephalotaxine backbone, being optionally substituted and/or dehydrogenated, in which formula I, X is a heteroatom, preferably an oxygen, a sulfur or a nitrogen, R 1 and R 2 , taken separately, may be alkyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, heterocycloalkyl or aralkyl groups, said groups being optionally interrupted by ester functions, or groups that can form one or more rings or a heterocycle together, consisting in bringing the corresponding cephalotaxine compound, or salts, isomers or tautomeric forms thereof, which is free or which is in the form of a metal alkoxide corresponding to the following general formula CTXOM, wherein CTX represents the cephalotaxine backbone, being optionally substituted and/or dehydrogenated, in which M is a hydrogen atom or a metal atom, into contact with a heterocyclic side chain precursor having both a bifunctional protected (bidentate) and activated (acylating) form of an acid bearing a hydrogenated heteroatom, in the alpha (α) position with respect to the carboxyl group, and corresponding to the following general formula: in which case W is a carbon, sulfur, silicon or bore atom, X, R 1 and R 2 have respectively the same meaning as above, it being possible for R 1 and R 2 to form a ring or a heterocycle together, and Y and Z are alkyl or heteroalkyl radicals, or monovalent heteroatoms, which may be identical or different, in an independent manner, or may fuse so as to give a divalent heteroatom, it being possible for the X-W bond to be covalent or ionic.

    Abstract translation: 一种制备对应于以下通式I的头孢噻肟酯的方法，其包含头孢噻肟主链：C（R 1）（R 2）（X H）COO [CTX]，其中CTX代表头孢噻肟主链任选被取代和/或脱氢，其中 式I，X是杂原子，优选氧，硫或氮，R 1和R 2分别独立地可以是烷基，环烷基，杂烷基，芳基，杂芳基，杂环烷基或芳烷基，所述基团任选被酯官能 ，或可以一起形成一个或多个环或杂环的基团，其包括使相应的头孢噻肟化合物或其盐，异构体或互变异构体形式，其为与下列一般相对应的金属醇盐形式， 式CTXOM，其中CTX代表头孢噻肟骨架，任选地被取代和/或脱氢，其中M是氢原子或金属原子与一个连接体接触 在相对于羧基的α（a）位上具有双功能保护（二齿）和活化（酰化）形式的含有氢化杂原子的酸的环状侧链前体，并且对应于以下通式：其中 情况W是碳，硫，硅或孔原子，X，R 1和R 2分别具有与上述相同的含义，R 1和R 2可以一起形成环或杂环，Y和Z是烷基或杂烷基 基团或单价杂原子，其可以相同或不同，以独立的方式，或可以融合以产生二价杂原子，XW键可以是共价键或离子型。

Patent Agency Ranking