公开(公告)号：WO1996032482A1

公开(公告)日：1996-10-17

申请号：PCT/IE1996000022

申请日：1996-04-12

Applicant: TEAGASC, THE AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY ,  RYAN, Maire, Philippa ,  ROSS, Reynolds, Paul ,  REA, Mary, Clare

Inventor： TEAGASC, THE AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY

IPC: C12N15/31

CPC classification number: A61Q11/00 ,  A23C19/0323 ,  A23C19/11 ,  A23L3/34635 ,  A61K8/64 ,  A61K38/00 ,  A61Q19/00 ,  C07K14/315

Abstract: The present invention relates to a novel anti-microbial agent, more particularly, a novel bacteriocin with nisin-like properties. The bacteriocin is designated lacticin 3147 and has the following properties: a molecular weight of approximately 2.8 kDa; inhibiting activity against lactococci, lactobacilli, enterococci, bacilli, leuconostocs, pediococci, clostridia, staphylococci and streptococci; sensivity to the proteases trypsin, alpha-chymotrypsin, proteinase K and pronase E but not pepsin; heat-stability; activity at acid pH; and the capability of inhibiting nisin-producing bacterial strains.

Abstract translation: 本发明涉及一种新的抗微生物剂，更特别地涉及一种具有乳链菌肽样性质的新型细菌素。 细菌素被命名为乳酸菌3147，具有以下性质：分子量约2.8kDa; 抑制乳球菌，乳杆菌，肠球菌，杆菌，明串珠菌，球菌，梭菌，葡萄球菌和链球菌的活性; 对蛋白酶胰蛋白酶，α-糜蛋白酶，蛋白酶K和链霉蛋白酶E而不是胃蛋白酶的敏感性; 热稳定性; 在酸性pH下的活性; 以及抑制乳链菌肽生成细菌菌株的能力。