公开(公告)号：WO2016025394A2

公开(公告)日：2016-02-18

申请号：PCT/US2015/044483

申请日：2015-08-10

Applicant: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULATURAL AND MECHANICAL COLLEGE ,  IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY ,  SABLIOV, Christina, M. ,  ASTETE, Carlos, E. ,  BODOKI, Ede ,  VOSTINARU, Oliviu ,  SAMOILA, Ovidiu, Ciprian ,  DINTE, Elena

Inventor： SABLIOV, Christina, M. ,  ASTETE, Carlos, E. ,  BODOKI, Ede ,  VOSTINARU, Oliviu ,  SAMOILA, Ovidiu, Ciprian ,  DINTE, Elena

IPC: A61K9/51

CPC classification number: A61K31/047 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/06 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/5146 ,  A61K9/5153 ,  A61K9/5169 ,  A61K31/05 ,  A61K47/34

Abstract: Methods and compositions are disclosed for delivering lutein or other antioxidant to target tissues such as the eye, in bioactive form, while protecting the antioxidant from degradation. The antioxidant is encapsulated in nanoparticles comprising a protein such as zein or a polymer such as poly(lactic-co-glycolic acid) (PLGA). Preferably a surfactant is associated with the nanoparticles as well, further helping to protect the antioxidant. After the nanoparticles are administered to the target tissue, bioactive antioxidant is released to the tissue over time. Optionally, the nanoparticles are admixed with a thermosensitive, bioadhesive gel to promote slow release of antioxidant. The methods and compositions are useful for treating or preventing conditions such as age-related macular degeneration or cataracts.

Abstract translation: 公开了用于将叶黄素或其他抗氧化剂以生物活性形式递送到靶组织如眼睛，同时保护抗氧化剂免于降解的方法和组合物。 抗氧化剂被包封在包含蛋白质例如玉米蛋白或聚合物例如聚（乳酸 - 乙醇酸共聚物）（PLGA）的纳米颗粒中。 优选表面活性剂也与纳米颗粒结合，进一步有助于保护抗氧化剂。 在将纳米颗粒施用于目标组织之后，随着时间的推移生物活性抗氧化剂被释放至组织。 任选地，纳米颗粒与热敏生物粘附凝胶混合以促进抗氧化剂的缓慢释放。 该方法和组合物可用于治疗或预防诸如年龄相关性黄斑变性或白内障的病症。

公开(公告)号：WO2016025394A3

公开(公告)日：2016-05-19

申请号：PCT/US2015044483

申请日：2015-08-10

Applicant: UNIV LOUISIANA STATE ,  IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY ,  SABLIOV CHRISTINA M ,  ASTETE CARLOS E ,  BODOKI EDE ,  VOSTINARU OLIVIU ,  SAMOILA OVIDIU CIPRIAN ,  DINTE ELENA

Inventor： SABLIOV CHRISTINA M ,  ASTETE CARLOS E ,  BODOKI EDE ,  VOSTINARU OLIVIU ,  SAMOILA OVIDIU CIPRIAN ,  DINTE ELENA

IPC: A61K9/66 ,  A61K31/045 ,  A61K47/30

CPC classification number: A61K31/047 ,  A61K9/0048 ,  A61K9/06 ,  A61K9/5146 ,  A61K9/5153 ,  A61K9/5169 ,  A61K31/05 ,  A61K47/34

Abstract: Methods and compositions are disclosed for delivering lutein or other antioxidant to target tissues such as the eye, in bioactive form, while protecting the antioxidant from degradation. The antioxidant is encapsulated in nanoparticles comprising a protein such as zein or a polymer such as poly(lactic-co-glycolic acid) (PLGA). Preferably a surfactant is associated with the nanoparticles as well, further helping to protect the antioxidant. After the nanoparticles are administered to the target tissue, bioactive antioxidant is released to the tissue over time. Optionally, the nanoparticles are admixed with a thermosensitive, bioadhesive gel to promote slow release of antioxidant. The methods and compositions are useful for treating or preventing conditions such as age-related macular degeneration or cataracts.

Abstract translation: 公开了用于将叶黄素或其它抗氧化剂以生物活性形式递送至目标组织如眼睛的方法和组合物，同时保护抗氧化剂免于降解。 将抗氧化剂包封在包含蛋白质如玉米蛋白的聚合物或聚（乳酸 - 共 - 乙醇酸）（PLGA）等聚合物中。 优选地，表面活性剂也与纳米颗粒结合，进一步有助于保护抗氧化剂。 将纳米颗粒施用于靶组织后，生物活性抗氧化剂随时间被释放到组织中。 任选地，将纳米颗粒与热敏生物粘附凝胶混合以促进抗氧化剂的缓慢释放。 所述方法和组合物可用于治疗或预防诸如年龄相关性黄斑变性或白内障的病症。