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    SUSTAINED RELEASE NANOCOMPOSITE, A PROCESS FOR PRODUCING THE SAME AND USE THEREOF
    5.
    发明申请
    SUSTAINED RELEASE NANOCOMPOSITE, A PROCESS FOR PRODUCING THE SAME AND USE THEREOF 审中-公开
    可持续发行纳米复合材料，其生产方法及其应用

    公开(公告)号：WO2017021748A1

    公开(公告)日：2017-02-09

    申请号：PCT/HU2016/050034

    申请日：2016-07-28

    Applicant: SZEGEDI TUDOMÁNYEGYETEM

    Inventor： DÉKÁNY, Imre ,  KRIZBAI, István ,  MAJLÁTH, Zsófia ,  TOLDI, József ,  VARGA, Noémi ,  VÉCSEI, László

    IPC: A61K9/51 ,  A61K31/00

    CPC classification number: A61K9/5169 ,  A61K9/5146 ,  A61K9/5161 ,  A61K31/00

    Abstract: The present invention relates to nanocomposites for the controlled delivery of active ingredients into the central nervous system. The nanocomposite according to the present invention comprises a biocompatible core part comprising biodegradable material, and polyelectrolytes able to form a electrostatic van der Waals interactions with the material of the core part. The core part of the nanocomposite is able to bind various pharmaceutical agents. The present invention also relates to a process for the preparation of the nanocomposite according to the present invention and to the use of the nanocomposite according to the present invention.

    Abstract translation: 本发明涉及用于将活性成分控制递送到中枢神经系统中的纳米复合材料。 根据本发明的纳米复合材料包括包含可生物降解材料的生物相容性核心部分和能够与核心部分的材料形成静电范德华相互作用的聚电解质。 纳米复合材料的核心部分能够结合各种药剂。 本发明还涉及制备根据本发明的纳米复合材料的方法和本发明的纳米复合材料的用途。

    FAS INHIBITORS AND METHODS ASSOCIATED THEREWITH
    9.
    发明申请
    FAS INHIBITORS AND METHODS ASSOCIATED THEREWITH 审中-公开
    FAS抑制剂及其相关方法

    公开(公告)号：WO2016076924A2

    公开(公告)日：2016-05-19

    申请号：PCT/US2015/042141

    申请日：2015-07-25

    Applicant: WAKE FOREST UNIVERSITY

    Inventor： MOHS, Aaron, M. ,  KREIDEL, Steve, J. ,  HILL, Tanner, K.

    IPC: A61K31/366 ,  A61K31/353

    CPC classification number: A61K31/519 ,  A61K9/5146 ,  A61K31/085 ,  A61K31/336 ,  A61K31/341 ,  A61K31/352 ,  A61K31/353 ,  A61K31/365 ,  A61K31/366 ,  A61K31/4965 ,  A61K45/06 ,  A61K47/61 ,  A61K47/6939 ,  A61K2300/00

    Abstract: The present invention relates to compounds, compositions and methods comprising nanopartieles (NP) that are based on hyaluronic acid (HLA) that have been modified with hydrophobic moieties that can entrap FASN inhibitor compounds. In one embodiment, the FASN inhibitor compounds include Orlistat In one embodiment, the hydrophobic moieties comprise 5-βCA, Pba, or ODA, or combinations thereof, in a variation, the present invention relates to a composition comprising MPs based upon HLA, Orlistat, one or more of the hydrophobic moieties comprising 5-βCA, Pba, or ODA, and one or more of members selected from the group consisting of PEG and -a dilute solution containing SDS.

    Abstract translation: 本发明涉及包含纳米颗粒（NP）的化合物，组合物和方法，所述纳米颗粒（NP）基于透明质酸（HLA），其已经被能够捕获FASN抑制剂化合物的疏水部分修饰。 在一个实施方案中，FASN抑制剂化合物包括奥利司他。在一个实施方案中，疏水部分包含5-βCA，Pba或ODA或其组合，在一个变体中，本发明涉及包含基于HLA，奥利司他， 一种或多种包含5-βCA，Pba或ODA的疏水部分和一种或多种选自PEG和含有SDS的稀溶液的成员中的一种或多种。

    DELIVERY OF BIOACTIVE, NANOENCAPSULATED ANTIOXIDANTS
    10.
    发明申请
    DELIVERY OF BIOACTIVE, NANOENCAPSULATED ANTIOXIDANTS 审中-公开
    提供生物活性，纳米抗氧化剂

    公开(公告)号：WO2016025394A3

    公开(公告)日：2016-05-19

    申请号：PCT/US2015044483

    申请日：2015-08-10

    Applicant: UNIV LOUISIANA STATE ,  IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY ,  SABLIOV CHRISTINA M ,  ASTETE CARLOS E ,  BODOKI EDE ,  VOSTINARU OLIVIU ,  SAMOILA OVIDIU CIPRIAN ,  DINTE ELENA

    Inventor： SABLIOV CHRISTINA M ,  ASTETE CARLOS E ,  BODOKI EDE ,  VOSTINARU OLIVIU ,  SAMOILA OVIDIU CIPRIAN ,  DINTE ELENA

    IPC: A61K9/66 ,  A61K31/045 ,  A61K47/30

    CPC classification number: A61K31/047 ,  A61K9/0048 ,  A61K9/06 ,  A61K9/5146 ,  A61K9/5153 ,  A61K9/5169 ,  A61K31/05 ,  A61K47/34

    Abstract: Methods and compositions are disclosed for delivering lutein or other antioxidant to target tissues such as the eye, in bioactive form, while protecting the antioxidant from degradation. The antioxidant is encapsulated in nanoparticles comprising a protein such as zein or a polymer such as poly(lactic-co-glycolic acid) (PLGA). Preferably a surfactant is associated with the nanoparticles as well, further helping to protect the antioxidant. After the nanoparticles are administered to the target tissue, bioactive antioxidant is released to the tissue over time. Optionally, the nanoparticles are admixed with a thermosensitive, bioadhesive gel to promote slow release of antioxidant. The methods and compositions are useful for treating or preventing conditions such as age-related macular degeneration or cataracts.

    Abstract translation: 公开了用于将叶黄素或其它抗氧化剂以生物活性形式递送至目标组织如眼睛的方法和组合物，同时保护抗氧化剂免于降解。 将抗氧化剂包封在包含蛋白质如玉米蛋白的聚合物或聚（乳酸 - 共 - 乙醇酸）（PLGA）等聚合物中。 优选地，表面活性剂也与纳米颗粒结合，进一步有助于保护抗氧化剂。 将纳米颗粒施用于靶组织后，生物活性抗氧化剂随时间被释放到组织中。 任选地，将纳米颗粒与热敏生物粘附凝胶混合以促进抗氧化剂的缓慢释放。 所述方法和组合物可用于治疗或预防诸如年龄相关性黄斑变性或白内障的病症。

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