公开(公告)号：WO1996009150A1

公开(公告)日：1996-03-28

申请号：PCT/JP1995001865

申请日：1995-09-19

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  KANEKA BELGIUM N.V. ,  SHIMAZU, Hisao ,  SENDA, Kenichi ,  SAKAGUCHI, Hirofumi ,  SMETS RONALDS, A. ,  VAN RAVESTYN, Pierre

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  KANEKA BELGIUM N.V.

IPC: B29B09/06

CPC classification number: B29B9/065 ,  B29B9/12 ,  B29C44/3461 ,  B29C47/00 ,  B29C47/0011 ,  B29K2023/00 ,  B29K2105/048 ,  B29K2105/16

Abstract: A method of manufacturing olefin resin particles, comprising the steps of extruding by using a homodirectional biaxal kneading extruder a resin from a die nozzle having a discharge rate per hole of 0.5-8 kg/hr and a diameter of less than 2 mm into warm water of 5-90 DEG C which is lower than the temperature of the resin by 140-220 DEG C, and then cutting the extruded product with a cutter blade in the warm water. The mixed materials are dispersed uniformly, and the changing of a raw resin is carried out speedily and economically, resin particles of a desired shape being obtained.

Abstract translation: 一种制造烯烃树脂颗粒的方法，包括以下步骤：通过使用双向双向捏合挤出机将来自每个孔的排出速率为0.5-8kg / hr和直径小于2mm的模头喷嘴的树脂挤出到温水 5-90℃，比树脂的温度低140-220℃，然后用切割刀在温水中切割挤出的产品。 混合材料均匀分散，并且快速且经济地进行原料树脂的变化，得到所需形状的树脂颗粒。

公开(公告)号：WO1992016237A1

公开(公告)日：1992-10-01

申请号：PCT/JP1992000225

申请日：1992-02-28

Applicant: HISAMITSU PHARMACEUTICAL CO., INC. ,  SATO, Syuji ,  MUKAE, Katsuya ,  HIGASHI, Yoshinobu ,  SUZUKI, Tatsuaki ,  MIZUMACHI, Mitsuhiro ,  SAKAGUCHI, Hirofumi

Inventor： HISAMITSU PHARMACEUTICAL CO., INC.

IPC: A61K47/14

CPC classification number: A61K8/37 ,  A61K8/34 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/14 ,  A61K2800/75 ,  A61Q17/00

Abstract: A composition for relieving skin irritation comprising 1 to 50 wt % of trialkyl citrate, 1 to 70 wt % of a lower alcohol and 1 to 90 wt % of water, and an external preparation for percutaneous administration comprising the above composition and further containing 0.001 to 20 wt % of a pharmacologically active substance, both of which can lower and relieve skin irritation and promote the absorption of the pharmacologically active substance.

公开(公告)号：WO1992019271A1

公开(公告)日：1992-11-12

申请号：PCT/JP1992000194

申请日：1992-02-24

Applicant: HISAMITSU PHARMACEUTICAL CO., INC. ,  SATO, Syuji; ,  MUKAE, Katsuya; ,  HIGASHI, Yoshinobu; ,  SUZUKI, Tatsuaki; ,  MIZUMACHI, Mitsuhiro; ,  SAKAGUCHI, Hirofumi;

Inventor： HISAMITSU PHARMACEUTICAL CO., INC.

IPC: A61K47/10

CPC classification number: A61K47/10 ,  A61K9/0014 ,  A61K47/14

Abstract: A percutaneous administration and absorption promoter composition which can remarkably promote the percutaneous absorption of pharmacologically active substances, characterized by containing a hydrophobic substance, water and a lower alcohol. An external preparation for percutaneous administration which permits pharmacologically active substances to be percutaneously administered efficiently to thereby attain a therapeutic effect, characterized by containing a pharmacologically active substance, a hydrophobic substance, water and a lower alcohol.

Abstract translation: 一种能够显着促进药理活性物质的经皮吸收的经皮给药吸收促进剂组合物，其特征在于含有疏水性物质，水和低级醇。 用于经皮给药的外用制剂，其允许有效地经皮施用药理活性物质，从而获得治疗效果，其特征在于含有药理活性物质，疏水性物质，水和低级醇。