公开(公告)号：WO1997005183A1

公开(公告)日：1997-02-13

申请号：PCT/JP1996002037

申请日：1996-07-19

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  OKURA, Tetsuo ,  KOUROGI, Mitsuharu ,  FUKUI, Yoshifumi ,  KIM, Hesun ,  TOMITA, Haruo ,  MIYAMA, Osamu ,  AOYAMA, Taizo

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

IPC: C08F255/04

CPC classification number: C08J9/04 ,  C08F255/02 ,  C08J2351/06 ,  C08L51/06 ,  C08F212/00 ,  C08F212/04

Abstract: A foam made from a modified polypropylene resin comprising a graft copolymer prepared by copolymerizing a polypropylene resin with an aromatic vinyl monomer, wherein the average number of aromatic vinyl graft chains grafted per graft copolymer molecule is 1 or above and the weight-average molecular weight of the aromatic vinyl graft chain is 200 or above; and a process for the production thereof. This foam has a high closed-cell ratio and a high expansion ratio and is excellent in appearance.

Abstract translation: 由改性聚丙烯树脂制成的泡沫体，其包含通过聚丙烯树脂与芳族乙烯基单体共聚而制备的接枝共聚物，其中每个接枝共聚物分子接枝的芳族乙烯基接枝链的平均数为1或更高，并且重均分子量为 芳族乙烯基接枝链为200以上; 及其生产方法。 该泡沫体的闭孔率高，膨胀率高，外观优异。

公开(公告)号：WO1996033217A1

公开(公告)日：1996-10-24

申请号：PCT/JP1996001039

申请日：1996-04-15

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  YAMASHITA, Kenji ,  NIWA, Hideo ,  OKAZAKI, Takeshi ,  FUKUCHI, Takeshi ,  OHARA, Takaaki ,  NISHINO, Tomoko ,  KAKUTANI, Tetsu

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

IPC: C07K14/705

CPC classification number: C07K14/70528 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00

Abstract: A novel cell adhesion protein having the effect of suppressing various immunological reactions and its analogs; a process for producing the same; an immunosuppressive agent containing the same; and another immunosuppressive agent containing as the active ingredient immunosuppressive cells obtained by incubating human cells in the presence of the cell adhesion protein. These immunosuppressive agents have potent immunosuppressive effects with little side effects.

Abstract translation: 具有抑制各种免疫反应及其类似物作用的新型细胞粘附蛋白; 其制造方法; 含有该免疫抑制剂的免疫抑制剂; 和含有作为活性成分的免疫抑制剂，其通过在细胞粘附蛋白的存在下培养人细胞而获得的免疫抑制细胞。 这些免疫抑制剂具有很强的免疫抑制作用，副作用很小。

公开(公告)号：WO1996025228A1

公开(公告)日：1996-08-22

申请号：PCT/JP1996000306

申请日：1996-02-09

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  HIRAI, Fumiyasu ,  TANI, Nobutaka ,  ASAHI, Takashi

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

IPC: B01J20/22

CPC classification number: C07K14/525 ,  A61M1/3679 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/327

Abstract: An adsorbent capable of efficiently removing tumor necrosis factor alpha (TNF- alpha ) present in a body fluid and comprising a compound having a functional group represented by general formula (I) and immobilized on a water-insoluble carrier (wherein X represents an anionic functional group; A represents a substituent other than the anionic functional group; and n represents an integer of 0 to 4, provided when n is 2 or above, nA's may be the same or different from each other); a method of removing TNF- alpha by adsorption comprising bringing the adsorbent into contact with a body fluid; and a device for adsorbing TNF- alpha by the adsorbent packed in a vessel equipped with an inlet and an outlet for a body fluid and provided with means for preventing the adsorbent from flowing out of the vessel.

Abstract translation: 一种吸附剂，其能够有效地除去存在于体液中的肿瘤坏死因子α（TNF-α），并且含有具有由通式（I）表示的官能团并固定在水不溶性载体上的化合物（其中X表示阴离子官能团 基团; A表示阴离子官能团以外的取代基，n表示0〜4的整数，n为2以上时，nA可以相同也可以不同）。 通过吸附除去TNF-α的方法，包括使吸附剂与体液接触; 以及用于通过填充在装备有用于体液的入口和出口的容器的容器中的吸附剂吸附TNF-α的装置，并且具有用于防止吸附剂从容器流出的装置。

公开(公告)号：WO1996020275A1

公开(公告)日：1996-07-04

申请号：PCT/JP1995002688

申请日：1995-12-26

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  NANBA, Hirokazu ,  YAJIMA, Kazuyoshi ,  TAKANO, Masayuki ,  YAMADA, Yukio ,  IKENAKA, Yasuhiro ,  TAKAHASHI, Satomi

IPC: C12N09/86

CPC classification number: C12P13/04 ,  C12N9/86 ,  C12P41/009 ,  C12Y305/02002

Abstract: A process for producing D-N-carbamoyl- alpha -amino acid from a 5-substituted hydantoin with the use of a hydantoinase produced by a microorganism transformed with a recombinant DNA with a vector DNA and the fragments of a DNA containing genes associated with a hydantoinase originating in a specified microorganism belonging to the genus Bacillus, Agrobacterium or Pseudomonas.

Abstract translation: 使用由具有载体DNA的重组DNA转化的微生物产生的乙内酰脲产生的由5-取代的乙内酰脲生产DN-氨基甲酰基-α-氨基酸的方法以及含有与源乙糖酶有关的基因的DNA的片段 在属于芽孢杆菌属，农杆菌属或假单胞菌属的特定微生物中。

公开(公告)号：WO1996016106A1

公开(公告)日：1996-05-30

申请号：PCT/JP1995002349

申请日：1995-11-16

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  NAKAGAWA, Yoshiki ,  KUSAKABE, Masato

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

IPC: C08G65/32

CPC classification number: C08F8/42 ,  C08G65/336 ,  C08G77/46

Abstract: A hydrosilylation method for introducing a hydrosilyl group into an olefin molecule by an addition reaction using a metal catalyst in the presence of a compound selected from among thiazoles and phosphines added to control the reaction, and a process for producing a hydrosilylated organic curing agent according to the above method. This method facilitates the control of the hydrosilylation reaction and the production of an organic-modified silicon compound having two or more hydrosilyl groups in its molecule. As a concomitant effect, the storage stability of the formed curing agent when both the catalyst and the additives of the invention remain therein is improved as compared with the case where only the catalyst remains therein.

Abstract translation: 一种氢化硅烷化方法，用于在选择噻唑和膦中的化合物存在下，通过使用金属催化剂的加成反应将氢化硅烷基引入到烯烃分子中，以控制反应，以及根据本发明的用于生产氢化硅烷化有机固化剂的方法 上述方法。 该方法有助于控制氢化硅烷化反应和在其分子中生产具有两个或多个氢化硅烷基的有机改性硅化合物。 作为伴随的效果，与仅保留催化剂的情况相比，保留本发明的催化剂和添加剂两者时形成的固化剂的保存稳定性提高。

公开(公告)号：WO1996015192A1

公开(公告)日：1996-05-23

申请号：PCT/JP1995002261

申请日：1995-11-07

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  YAMASHITA, Koichi ,  KOBAYASHI, Hiroshi ,  ASADA, Masahiro

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

IPC: C08L77/00

CPC classification number: C08L77/00 ,  C08F279/02 ,  C08L25/12 ,  C08L51/00 ,  C08L51/04 ,  C08L2666/02 ,  C08L25/00

Abstract: A heat-resistant thermoplastic resin composition comprising 5-95 parts by weight of a polyamide resin (A), 5-95 parts by weight of an unsaturated carboxylic acid copolymer (B) comprising 40-80 wt.% of an aromatic vinyl compound, 15-50 wt.% of a vinyl cyanide compound, 0.1-20 wt.% of an unsaturated carboxylic acid compound and 0-30 wt.% of other copolymerizable vinyl compound, and 5-50 parts by weight of a graft copolymer (C) prepared by grafting 60-5 wt.% of a vinyl compound onto 40-95 wt.% of a diene rubber having an average particle diameter of 0.1-2.0 mu m, which composition further contains kaolin (D) in an amount of 0.1-30 parts by weight per 100 parts by weight in total of the components (A), (B) and (C). The composition provides moldings excellent in thermal deformation and impact resistances and appearance, and has a good flowability in molding.

Abstract translation: 一种耐热性热塑性树脂组合物，其包含5-95重量份的聚酰胺树脂（A），5-95重量份的包含40-80重量％的芳族乙烯基化合物的不饱和羧酸共聚物（B） 15-50重量％的乙烯基氰化合物，0.1-20重量％的不饱和羧酸化合物和0-30重量％的其它可共聚乙烯基化合物和5-50重量份接枝共聚物（C ）通过将60-5重量％的乙烯基化合物接枝到40-95重量％的平均粒径为0.1-2.0μm的二烯橡胶中，该组合物还含有0.1重量％的高岭土（D） 相对于组分（A），（B）和（C）的总计100重量份，为-30重量份。 该组合物提供了热变形和耐冲击性和外观优异的模制品，并且在成型中具有良好的流动性。

公开(公告)号：WO1996013543A1

公开(公告)日：1996-05-09

申请号：PCT/JP1995002216

申请日：1995-10-27

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  MUNAKATA, Yasumitsu ,  SENDA, Kenichi

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

IPC: C08J09/16

CPC classification number: C08J9/16 ,  C08J2323/12

Abstract: Prefoamed polypropylene resin particles with a lowered peak temperature in melting so as to lower the heating temperature of a final foam in expansion molding. The particle comprises a polypropylene resin and a beta crystal nucleator, the content of the DOLLAR (g)b crystals in the crystalline region as a whole being adjusted to 5-100 parts by weight.

Abstract translation: 熔融时峰值温度降低的预发泡聚丙烯树脂颗粒，以降低发泡成型中最终泡沫体的加热温度。 颗粒包括聚丙烯树脂和β晶体成核剂，整个结晶区域中DOLLAR（g）b晶体的含量被调节至5-100重量份。

公开(公告)号：WO1996009150A1

公开(公告)日：1996-03-28

申请号：PCT/JP1995001865

申请日：1995-09-19

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  KANEKA BELGIUM N.V. ,  SHIMAZU, Hisao ,  SENDA, Kenichi ,  SAKAGUCHI, Hirofumi ,  SMETS RONALDS, A. ,  VAN RAVESTYN, Pierre

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  KANEKA BELGIUM N.V.

IPC: B29B09/06

CPC classification number: B29B9/065 ,  B29B9/12 ,  B29C44/3461 ,  B29C47/00 ,  B29C47/0011 ,  B29K2023/00 ,  B29K2105/048 ,  B29K2105/16

Abstract: A method of manufacturing olefin resin particles, comprising the steps of extruding by using a homodirectional biaxal kneading extruder a resin from a die nozzle having a discharge rate per hole of 0.5-8 kg/hr and a diameter of less than 2 mm into warm water of 5-90 DEG C which is lower than the temperature of the resin by 140-220 DEG C, and then cutting the extruded product with a cutter blade in the warm water. The mixed materials are dispersed uniformly, and the changing of a raw resin is carried out speedily and economically, resin particles of a desired shape being obtained.

Abstract translation: 一种制造烯烃树脂颗粒的方法，包括以下步骤：通过使用双向双向捏合挤出机将来自每个孔的排出速率为0.5-8kg / hr和直径小于2mm的模头喷嘴的树脂挤出到温水 5-90℃，比树脂的温度低140-220℃，然后用切割刀在温水中切割挤出的产品。 混合材料均匀分散，并且快速且经济地进行原料树脂的变化，得到所需形状的树脂颗粒。

公开(公告)号：WO1995025754A1

公开(公告)日：1995-09-28

申请号：PCT/JP1995000486

申请日：1995-03-17

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  FUJISAWA, Hiroshi ,  DEGUCHI, Yoshikuni ,  NODA, Koji ,  ISURUGI, Masakazu ,  TAMURA, Masanobu ,  HAZAMA, Junichi ,  IKEDA, Tsutomu ,  WACHI, Shun

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

IPC: C08F06/06

CPC classification number: C08F6/02 ,  C08F8/26 ,  C08F210/10

Abstract: An advantageous process for producing an unsaturated telechelic isobutylene polymer wherein the formed polymer is isolated in a nonaqueous system to prevent the occurrence of an effluent containing the solvent dissolved therein. The process comprises: a method of isolating an isobutylene polymer in a nonaqueous cationic polymerization reaction using a catalyst represented by the general formula (I): MXn (wherein M represents a metal atom; n represents an integer of 2 to 6; and Xs represent each independently halogen or a monovalent hydrocarbon group), characterized by conducting catalyst ligand exchange after the polymerization and removing the component containing the atom M of the above formula (I); a method of isolating an isobutylene polymer in a nonaqueous cationic polymerization reaction using a catalyst represented by the above formula (I), characterized by forming a telechelic isobutylene polymer and removing the catalyst by using an adsorbent capable of adsorbing acids; and a method of isolating an isobutylene polymer in a nonaqueous cationic polymerization reaction using a catalyst represented by the above formula (I), characterized by adding a compound represented by the following general formula (II): Q(OR)m, (wherein Q represents a group Ia, IIa, IIIb or IVa metal atom of the Periodic Table; m represents an integer of 1 to 6; and R represents hydrogen or a monovalent organic group, provided when m is 2 or more, mR's may be the same or different from each other) after the polymerization to eliminate the HC1 molecule from the polymer chain end and conduct catalyst ligand exchange to thereby form an unsaturated telechelic isobutylene polymer, and removing the component containing the atom M of the above formula (I).

Abstract translation: 制备不饱和遥爪异丁烯聚合物的有利方法，其中形成的聚合物在非水系统中分离以防止含有溶剂溶解的流出物的出现。 该方法包括：使用由通式（I）表示的催化剂在非水阳离子聚合反应中分离异丁烯聚合物的方法：MXn（其中M表示金属原子; n表示2至6的整数; X表示 各自独立地为卤素或一价烃基），其特征在于在聚合后进行催化剂配体交换并除去含有上述式（I）的原子M的组分; 使用由上述式（I）表示的催化剂在非水阳离子聚合反应中分离异丁烯聚合物的方法，其特征在于，形成遥爪异丁烯聚合物并通过使用能够吸附酸的吸附剂除去催化剂; 以及使用上述式（I）表示的催化剂在非水阳离子聚合反应中分离异丁烯聚合物的方法，其特征在于，添加下述通式（II）表示的化合物：Q（OR）m，（其中Q 表示周期表中的Ia，IIa，IIIb或IVa族金属原子; m表示1至6的整数; R表示氢或一价有机基团，当m为2或更大时，mR可以相同或者 彼此不同），从聚合物链端除去HC1分子，进行催化剂配体交换，从而形成不饱和的遥爪异丁烯聚合物，并除去含有上述式（I）的原子M的成分。

公开(公告)号：WO1995015184A1

公开(公告)日：1995-06-08

申请号：PCT/JP1994002003

申请日：1994-11-29

Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA ,  GEJYO, Fumitake ,  NAKATANI, Masaru ,  FURUYOSHI, Shigeo ,  TAKATA, Satoshi

Inventor： KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

IPC: A61K51/02

CPC classification number: A61K51/1093 ,  A61K51/088 ,  A61K2123/00

Abstract: A substance for detecting amyloid deposition and/or deposition site with excellent utility and safety, which is prepared by combining an amyloid-forming protein with a metal chelating substance. It is possible to obtain clear images of amyloid deposition and/or deposition site safely in a short time by labeling the invention substance with a radio-isotope via the metal chelating substance.

Abstract translation: 用于检测淀粉样蛋白沉积和/或沉积位置的物质，其具有优异的用途和安全性，其通过将淀粉样蛋白形成蛋白质与金属螯合物质组合而制备。 通过经由金属螯合物质用放射性同位素标记本发明物质，可以在短时间内安全地获得淀粉样蛋白沉积和/或沉积位置的清晰图像。