公开(公告)号：WO2011028334A3

公开(公告)日：2011-03-10

申请号：PCT/US2010/043109

申请日：2010-07-23

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  BAKER, JR., James R. ,  BANASZAK HOLL, Mark M. ,  MULLEN, Douglas Gurnett ,  ORR, Bradford G. ,  DESAI, Ankur ,  SANDER, Leonard M. ,  WADDELL, Jack Neel

Inventor： BAKER, JR., James R. ,  BANASZAK HOLL, Mark M. ,  MULLEN, Douglas Gurnett ,  ORR, Bradford G. ,  DESAI, Ankur ,  SANDER, Leonard M. ,  WADDELL, Jack Neel

IPC: A61K31/74 ,  A61K47/48 ,  A61K47/34 ,  A61K31/4985 ,  A61K9/20 ,  A61P35/00

Abstract: The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)).

公开(公告)号：WO2011028334A2

公开(公告)日：2011-03-10

申请号：PCT/US2010043109

申请日：2010-07-23

Applicant: UNIV MICHIGAN ,  BAKER JR JAMES R ,  BANASZAK HOLL MARK M ,  MULLEN DOUGLAS GURNETT ,  ORR BRADFORD G ,  DESAI ANKUR ,  SANDER LEONARD M ,  WADDELL JACK NEEL

Inventor： BAKER JR JAMES R ,  BANASZAK HOLL MARK M ,  MULLEN DOUGLAS GURNETT ,  ORR BRADFORD G ,  DESAI ANKUR ,  SANDER LEONARD M ,  WADDELL JACK NEEL

IPC: A61K31/74 ,  A61K9/20 ,  A61K31/4985 ,  A61K47/34 ,  A61K47/48 ,  A61P35/00

CPC classification number: C08G83/004

Abstract: The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)).

Abstract translation: 本发明涉及树枝状大分子体系的合成和分离的新方法。 特别地，本发明涉及具有限定数量和限定数量的配体缀合物和高水平结构均匀性的新型树状聚合物缀合物，其合成方法，包含缀合物的组合物以及利用缀合物的系统和方法（例如， 在诊断和/或治疗设置（例如，用于递送治疗剂，成像和/或靶向剂（例如，在疾病（例如，癌症）诊断和/或治疗，疼痛治疗等中））。