公开(公告)号：WO2019091878A1

公开(公告)日：2019-05-16

申请号：PCT/EP2018/080077

申请日：2018-11-05

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： HELMER, Michael ,  JUGL, Michael ,  SCHABBACH, Michael ,  RAU, Matthias ,  KERSTING, Julian ,  THURNES, Andrea

IPC: A61M5/315

CPC classification number: A61M5/31536 ,  A61M5/20 ,  A61M5/31551 ,  A61M5/3156 ,  A61M5/31586 ,  A61M2005/3154

Abstract: The present disclosure relates to an injection device for setting and injecting a dose of a medicament, the injection device comprising: - an elongated housing (10) extending along a longitudinal axis (z) and having a distal end (41) and a proximal end (42), a dose tracker (50; 150; 250; 350; 450; 550) being at least one of translationally or rotationally displaceable relative to the housing (10) and being displaceable between a zero dose positional state (52) and a maximum dose positional (54) state relative to the housing (10) for setting of the dose, wherein the positional state (52, 54) of the dose tracker (50; 150) relative to the housing (10) is indicative of a size of the dose, wherein one of the elongated housing (10) and the dose tracker (50; 150; 250; 350; 450) comprises at least one tracking stop feature (51; 151; 251; 351; 451; 551 ), a preselector (70; 170; 270; 370; 470; 570) displaceable relative to the housing (10) between at least two preselection positional states (72, 74) thereby defining the maximum dose positional state (54) of the dose tracker (50; 150; 250; 350; 450; 550), wherein the preselector (17; 170; 270; 370; 470; 570) comprises at least one preselector stop feature (71; 171; 271; 371; 471 ) configured to mechanically engage with the at least one tracking stop feature (51; 151; 251; 351; 551 ) to block a displacement of the dose tracker (50; 150; 250; 350; 450; 550) beyond the maximum dose positional state (54).

公开(公告)号：WO2018166985A1

公开(公告)日：2018-09-20

申请号：PCT/EP2018/056111

申请日：2018-03-12

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： DASBACH, Uwe ,  SCHADER, Marc ,  KNEIP, Michael ,  RAU, Matthias ,  NOBER, Peter

IPC: A61M5/20

Abstract: The present disclosure relates to a drug delivery device (1), having a longitudinal axis (L) and comprising a plunger (10) movable along the longitudinal axis (L) and a guide curve (2.18) adapted to engage at least one part (10.2, 10.2, 10.3) of the plunger (10) so as to guide the plunger (10) when the plunger (10) is being released to move along the longitudinal axis (L).

公开(公告)号：WO2018138192A1

公开(公告)日：2018-08-02

申请号：PCT/EP2018/051811

申请日：2018-01-25

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： HAMMEN, Dietmar ,  KLEMM, Thomas

IPC: A61M5/24 ,  A61M5/315 ,  A61M5/31

Abstract: Implementations of the present disclosure are directed to a module for attachment to an injection device that includes a flexible carrier foil configured to be attached to a surface of the injection device independent of a geometry of the surface, at least one light emitting diode attached to the flexible carrier foil in a first position and configured to emit a light signal in a direction based on the first position through a transparent wall of the injection device, at least one photodiode attached to the flexible carrier foil in a second position relative to the first position, the at least one photodiode being configured to detect at least a portion of the light signal from a direction based on the second position and being configured to emit an electrical signal based on the light signal to a microprocessor, and wherein the microprocessor is configured to receive the electrical signal emitted by the photodiode and to determine the position of a stopper and the amount of the fluid within the injection device based at least in part on the electrical signal.

公开(公告)号：WO2018082886A1

公开(公告)日：2018-05-11

申请号：PCT/EP2017/076048

申请日：2017-10-12

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： BAUMEYER, Martin ,  NOBER, Peter ,  RAU, Matthias ,  HUTHMACHER, Winfried ,  JANIAK, Markus

IPC: A61M5/315

Abstract: The present invention relates to a feedback mechanism (20) for an injection device that is configured to deliver a medicament to a user. The feedback mechanism (20) has a biasing member that is arranged to apply a force to a delay element (30), and the delay element (30) is configured to deform and/or break under the force. The feedback mechanism (20) also includes an indicator (24) arranged to generate user feedback after the delay element (30) is deformed and/or broken. The delay element (30) is configured to deform and/or break at a time after the force is applied by the biasing member to create a delay before the user feedback is generated.

Abstract translation: 本发明涉及一种用于注射装置的反馈机构（20），该注射装置构造成向使用者递送药剂。 所述反馈机构（20）具有偏置构件，所述偏置构件被布置成向延迟元件（30）施加力，并且所述延迟元件（30）被构造成在所述力的作用下变形和/或断裂。 反馈机构（20）还包括布置成在延迟元件（30）变形和/或破坏之后产生用户反馈的指示器（24）。 延迟元件（30）被配置成在偏置构件施加力之后的一段时间变形和/或断开，以在产生用户反馈之前产生延迟。

公开(公告)号：WO2018069121A1

公开(公告)日：2018-04-19

申请号：PCT/EP2017/075256

申请日：2017-10-04

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： HELMER, Michael ,  SCHADER, Marc

IPC: A61M5/178 ,  A61M5/32

Abstract: A drug delivery device comprising a housing, said housing containing a syringe, wherein the syringe comprises: a container containing a liquid medicament, said container comprising an aperture at a distal end thereof and through which said liquid medicament can be dispensed; a stopper within said container, said stopper moveable between a first longitudinal position and a second longitudinal position relative to the container, to cause dispensing of said liquid medicament through said aperture; and at least one identifying means identifying the liquid medicament.

Abstract translation: 药物输送装置，包括壳体，所述壳体包含注射器，其中所述注射器包括：容纳液体药物的容器，所述容器在其远端包括孔口，并且所述液体药剂 可以分配; 在所述容器内的止动件，所述止动件可相对于所述容器在第一纵向位置和第二纵向位置之间移动，以使所述液体药剂通过所述孔分配; 和至少一个识别液体药物的识别装置。

公开(公告)号：WO2018060027A1

公开(公告)日：2018-04-05

申请号：PCT/EP2017/073725

申请日：2017-09-20

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： SOARES, Francisco ,  FORYS, Bernhard ,  VERLAAK, Stefan ,  MELZI, Ilario

IPC: A61M5/148 ,  A61M5/20 ,  A61M5/142 ,  A61M5/145 ,  A61M5/315 ,  A61M5/158

Abstract: The present invention relates to a medicament delivery device (10). The medicament delivery device (10) comprises a housing (11), a needle (12) and a needle actuating mechanism (14). The needle actuating mechanism (14) is configured to rotate the needle (12) relative to the housing (11) to move the needle (12) from a stowed position to a primed position. The present invention also relates to a method of operating a medicament delivery device (10).

Abstract translation: 药物输送装置（10）技术领域本发明涉及一种药物输送装置（10）。 药物输送装置（10）包括壳体（11），针（12）和针致动机构（14）。 针致动机构（14）构造成使针（12）相对于壳体（11）旋转以将针（12）从收起位置移动到准备好的位置。 本发明还涉及一种操作药物输送装置（10）的方法。

公开(公告)号：WO2018060026A1

公开(公告)日：2018-04-05

申请号：PCT/EP2017/073724

申请日：2017-09-20

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： SCHABBACH, Michael ,  FRANKE, Beate ,  PRADEL, Giuliano ,  MELZI, Ilario ,  VERLAAK, Stefan ,  NELSON, Andrew

IPC: A61M5/142

Abstract: The present invention relates to a medicament delivery device. The medicament delivery device comprises a housing, a needle, a medicament delivery mechanism and an actuator. The needle is moveable from a retracted position, wherein the needle is fully received in the housing, to an extended position, wherein the needle protrudes out of the housing. The medicament delivery mechanism comprises a reservoir and dispensing member each disposed in the housing, first and second biasing members, and first and second locking members. The actuator is moveable relative to the housing from an initial position to an intermediate position such that the actuator exerts a force on the first locking member to urge the first locking member from a locked state to an unlocked state wherein the first biasing member moves the needle from the retracted position to the extended position. The actuator is moveable relative to the housing from the intermediate position to a second position such that the actuator exerts a force on the second locking member to urge the second locking member from a locked state to an unlocked state wherein the second biasing member moves the dispensing member within the housing to dispense medicament from the reservoir when the reservoir contains medicament.

Abstract translation: 药物输送装置技术领域本发明涉及一种药物输送装置。 药物输送装置包括壳体，针，药物输送机构和致动器。 针可从其中针完全容纳在壳体中的缩回位置移动到伸出位置，其中针伸出壳体。 药物输送机构包括均设置在壳体中的储存器和分配构件，第一和第二偏置构件以及第一和第二锁定构件。 致动器可相对于壳体从初始位置移动到中间位置，使得致动器在第一锁定构件上施加力以将第一锁定构件从锁定状态推动到解锁状态，其中第一偏置构件移动针 从缩回位置到延伸位置。 致动器可相对于壳体从中间位置移动到第二位置，使得致动器在第二锁定构件上施加力以将第二锁定构件从锁定状态推动到解锁状态，其中第二偏置构件移动分配 当贮存器含有药物时，在壳体内部从贮存器分配药物。

公开(公告)号：WO2018046660A1

公开(公告)日：2018-03-15

申请号：PCT/EP2017/072578

申请日：2017-09-08

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： KLEMM, Thomas

IPC: A61M5/20 ,  A61M5/31

Abstract: The disclosure provides a reading device (2, 20) adapted to read-out infrared readable data (D, D 10 ) provided by a covered part (1.1.1.2, 10.1.1.2) of a movable component (1.1, 10.1) of a drug delivery device (1, 10), wherein the reading device (2, 20) comprises - at least one electromagnetic radiation source (2.2, 20.2) configured to emit infrared radiation and adapted to illuminate the infrared readable data (D, D 10 ) on the covered part (1.1.1.2, 10.1.1.2), - at least one optical sensor unit (2.3, 20.3) configured to detect infrared radiation reflected from the covered part (1.1.1.2, 10.1.1.2) of the movable component (1.1, 10.1) and - at least one processing unit (2.4, 20.4) configured to determine a data value of the infrared readable data (D, D10) as a function of the detected reflected infrared radiation. The disclosure further provides a drug delivery device (1, 10) and a drug delivery device (1, 10) in combination with the reading device (2, 20).

Abstract translation: 本公开提供了一种读取设备（2,20），其适于读取由被覆盖部分（1.1.1.2，提供者）提供的红外线可读数据（D，D _{其特征在于，所述读取装置（2,20）包括： - 至少一个电磁辐射源（2.2,20.2），所述电磁辐射源被构造成发射红外线 辐射并且适于照射被覆盖部分（1.1.1.2,10.1.1.2）上的红外可读数据（D，D 10 ）， - 至少一个光学传感器单元（2.3,20.3）配置成 检测从可移动部件（1.1,10.1）的被覆盖部分（1.1.1.2,10.1.1.2）反射的红外辐射，以及 - 至少一个处理单元（2.4,20.4），被配置为确定红外可读数据的数据值 D，D10）作为检测到的反射红外辐射的函数。 本公开还提供了与读取装置（2,20）组合的药物输送装置（1,10）和药物输送装置（1,10）。}

公开(公告)号：WO2018041798A8

公开(公告)日：2018-03-08

申请号：PCT/EP2017/071596

申请日：2017-08-29

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： MICHAEL, Helmer ,  MELZI, Ilario ,  HON, Bodin

IPC: A61M5/20

Abstract: In one aspect the present disclosure refers to a supplementary device (50;150) for an injection device (1), the supplementary device comprising: - a body (51; 151) attachable to a housing (2) of the injection device (1), the body (51; 51) having a first portion (68) facing towards the housing (2) when attached to the housing (2), - at least one light source (52) attached to the body (51; 151), and - at least a first optical coupling (54) located in or at the first portion (68), connected to the at least one light source (52) in a light transmissive way and optically connectable to a second optical coupling (14) arranged in or on the housing (2).

公开(公告)号：WO2018037030A1

公开(公告)日：2018-03-01

申请号：PCT/EP2017/071194

申请日：2017-08-23

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： HELMER, Michael

IPC: A61M5/315

Abstract: The present disclosure relates to an audible indicator (13) for use with a drug delivery device (1) comprising a spring element (13.10) configured to reside in one of a relaxed state (S1) and a biased state (S2), - wherein the audible indicator (13) comprises a rotatable element (13.1) coupled to the spring element (13.10), - wherein the spring element (13.10) releases stored energy to rotate the rotatable element (13.1) such that the rotatable element (13.1) impacts a surface to generate an audible signal when the spring element (13.10) changes from the biased state (S2) into the relaxed state (S1).

Abstract translation: 本公开涉及与药物输送装置（1）一起使用的可听指示器（13），所述药物输送装置包括配置成驻留在松弛状态（S1）和松弛状态（S1）中的一个中的弹簧元件 （13），其中所述可听指示器（13）包括联接到所述弹簧元件（13.10）的可旋转元件（13.1），其中所述弹簧元件（13.10）释放储存的能量以旋转所述可旋转元件 当弹簧元件（13.10）从偏置状态（S2）变为松弛状态（S1）时，可旋转元件（13.1）撞击表面以产生可听信号。