公开(公告)号：WO2009042194A3

公开(公告)日：2009-05-14

申请号：PCT/US2008011147

申请日：2008-09-25

Applicant: TRIMERIS INC ,  BRAY BRIAN L ,  JOHNSTON BARBARA E ,  SCHNEIDER STEPHEN E ,  TVERMOES NICOLAI A ,  ZHANG HUYI ,  FRIEDRICH PAUL E

Inventor： BRAY BRIAN L ,  JOHNSTON BARBARA E ,  SCHNEIDER STEPHEN E ,  TVERMOES NICOLAI A ,  ZHANG HUYI ,  FRIEDRICH PAUL E

IPC: C07K14/16

CPC classification number: C07K14/005 ,  A61K38/00 ,  C07K2319/00 ,  C12N2740/16122

Abstract: Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.

Abstract translation: 本文提供了合成肽的方法。 特别地，本文提供了治疗性抗病毒肽的合成方法。

公开(公告)号：WO1987004399A1

公开(公告)日：1987-07-30

申请号：PCT/US1987000237

申请日：1987-01-21

Applicant: KRANSCO MANUFACTURING, INC. ,  GELLER, Douglas, A. ,  SCHNEIDER, Stephen, E.

Inventor： KRANSCO MANUFACTURING, INC.

IPC: B63B41/00

CPC classification number: B63B35/7926

Abstract: A generally trapezoidal fin (22) is pivotally fastened to a casing which can receive the entire fin, permitting total retraction of the fin. The casing is formed with at least one notch (42) for selectively positioning the fin relative to the casing. In a preferred embodiment, the fin is operated by a lever member (26) which has a knob (50) at its distal end for use in positioning the fin (22) from above.

Abstract translation: 大致梯形的翅片（22）枢转地固定到可以容纳整个翅片的壳体上，允许翅片完全缩回。 壳体形成有至少一个凹口（42），用于相对于壳体选择性地定位翅片。 在优选实施例中，翅片由杠杆构件（26）操作，杠杆构件（26）在其远端具有旋钮（50），用于从上方定位翅片（22）。

公开(公告)号：WO2009042194A2

公开(公告)日：2009-04-02

申请号：PCT/US2008/011147

申请日：2008-09-25

Applicant: TRIMERIS, INC. ,  BRAY, Brian, L. ,  JOHNSTON, Barbara, E. ,  SCHNEIDER, Stephen, E. ,  TVERMOES, Nicolai, A. ,  ZHANG, Huyi ,  FRIEDRICH, Paul, E.

Inventor： BRAY, Brian, L. ,  JOHNSTON, Barbara, E. ,  SCHNEIDER, Stephen, E. ,  TVERMOES, Nicolai, A. ,  ZHANG, Huyi ,  FRIEDRICH, Paul, E.

IPC: C07K14/16

CPC classification number: C07K14/005 ,  A61K38/00 ,  C07K2319/00 ,  C12N2740/16122

Abstract: Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.

Abstract translation: 本文提供了合成肽的方法。 特别地，本文提供了治疗性抗病毒肽的合成方法。

公开(公告)号：WO2007097903A3

公开(公告)日：2007-08-30

申请号：PCT/US2007/002990

申请日：2007-02-02

Applicant: TRIMERIS, INC. ,  DWYER, John ,  BRAY, Brian, L. ,  SCHNEIDER, Stephen, E. ,  ZHANG, Huyi ,  TVERMOES, Nicolai, A. ,  JOHNSTON, Barbara, E. ,  FRIEDRICH, Paul, E.

Inventor： DWYER, John ,  BRAY, Brian, L. ,  SCHNEIDER, Stephen, E. ,  ZHANG, Huyi ,  TVERMOES, Nicolai, A. ,  JOHNSTON, Barbara, E. ,  FRIEDRICH, Paul, E.

IPC: C07K5/00

Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9. SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO: 15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.

公开(公告)号：WO2007097903A2

公开(公告)日：2007-08-30

申请号：PCT/US2007002990

申请日：2007-02-02

Applicant: TRIMERIS INC ,  DWYER JOHN ,  BRAY BRIAN L ,  SCHNEIDER STEPHEN E ,  ZHANG HUYI ,  TVERMOES NICOLAI A ,  JOHNSTON BARBARA E ,  FRIEDRICH PAUL E

Inventor： DWYER JOHN ,  BRAY BRIAN L ,  SCHNEIDER STEPHEN E ,  ZHANG HUYI ,  TVERMOES NICOLAI A ,  JOHNSTON BARBARA E ,  FRIEDRICH PAUL E

IPC: C07K14/00 ,  A61K38/00 ,  C07K1/00 ,  C07K2/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N2740/16022 ,  C12N2740/16122 ,  G01N2333/16 ,  G01N2800/26

Abstract: Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9. SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO: 15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.

Abstract translation: 本发明提供具有SEQ ID NO：9中任一项的氨基酸序列的HIV融合抑制肽。 SEQ ID NO：10，SEQ ID NO：11，SEQ ID NO：12，SEQ ID NO：13，SEQ ID NO：14或SEQ ID NO：15; 并且提供了包含HIV融合抑制剂肽和药学上可接受的载体和大分子载体中的一种或多种的药物组合物，以及由这些组合物提供的用途和治疗方法。