公开(公告)号：WO2003072156A1

公开(公告)日：2003-09-04

申请号：PCT/CH2002/000125

申请日：2002-02-28

Applicant: EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH OBERFLÄCHENTECHNIK ,  SIMPSON, James, P. ,  DENZER, Alain, J. ,  BOYAN, Barbara, D. ,  SCHWARTZ, Zvi, D. ,  TOSATTI, Samuele ,  SPENCER, Nicholas, D. ,  TEXTOR, Marcus

Inventor： SIMPSON, James, P. ,  DENZER, Alain, J. ,  BOYAN, Barbara, D. ,  SCHWARTZ, Zvi, D. ,  TOSATTI, Samuele ,  SPENCER, Nicholas, D. ,  TEXTOR, Marcus

IPC: A61L27/34

CPC classification number: A61L27/34 ,  C08L101/02

Abstract: The invention relates to a device with a surface covered by a thin film or monolayer of a poly (ethylene glycol)-grafted copolymer exhibiting osteogenic properties, defined in an osteoblastic cell culture test as a surface that increases the expression of growth factor TFG-β1, the expression of hormone PGE 2 and/or the expression of mineralization marker osteocalcin by at least a factor of 2 in comparison to the corresponding control surface consisting of either unmodified substrate surface or of tissue-culture polystyrene (TCPS).

Abstract translation: 本发明涉及一种具有表面覆盖的表面的器件，其表现出成骨细胞培养试验中定义的表现成骨形成特性的聚（乙二醇）移植共聚物的薄膜或单层，作为增加生长因子TFG-β1的表达的表面 ，与由未修饰的底物表面或组织培养聚苯乙烯（TCPS）组成的相应的对照表面相比，激素PGE2的表达和/或矿化标记骨钙素的表达至少为2倍。