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公开(公告)号：WO2013014466A1
公开(公告)日：2013-01-31
申请号：PCT/GB2012/051817
申请日：2012-07-27
申请人： Q CHIP LIMITED , PALMER, Daniel David , SHADICK, Owen Lesley , BARTLEY, Stuart James , JOHN, Brynmor Alexander
CPC分类号： F26B5/12 , B01D21/2405 , B01D21/2411 , B01D21/267 , B01J2/18 , B01J19/0093
摘要： A device is provided for separating beads from a carrier fluid, the device comprising: a bead-receiving means for receiving beads dispersed in a carrier fluid, a fluid removal means operable to remove fluid from the bead-receiving means in a first fluid removal zone by the application of reduced pressure, and a bead collection means operable to remove beads from the bead-receiving means in a bead collection zone by the application of reduced pressure, the bead-receiving means being movable so that beads are movable from the first fluid removal zone to the bead collection zone.
摘要翻译： 提供了一种用于从载体流体分离珠粒的装置，该装置包括：用于接收分散在载体流体中的珠粒的珠粒接收装置，可操作以在第一流体去除区域中从珠粒接收装置移除流体的流体移除装置 通过施加减压，以及可操作以通过施加减压从珠收集区中的珠接收装置移除珠的珠收集装置，珠接收装置可移动，使得珠可以从第一流体 去除区到珠收集区。
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公开(公告)号：WO2010004253A2
公开(公告)日：2010-01-14
申请号：PCT/GB2009/001492
申请日：2009-06-16
申请人： Q CHIP LIMITED , PALMER, Daniel , CALDER, Richard , SHADICK, Owen
发明人： PALMER, Daniel , CALDER, Richard , SHADICK, Owen
IPC分类号： B01J2/08
CPC分类号： B01J2/08 , A61K9/1647 , A61K9/1694
摘要： A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid 'in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.
摘要翻译： 公开了一种制备固体珠粒的方法，所述方法包括：（i）提供微流体装置，其包括在连接区域相遇的载体流体导管和功能流体导管; （ii）提供功能流体的层流，其包括沿着功能流体导管的溶剂和溶质，并且沿着载体流体导管提供载体流体的层流，以在载体流中形成功能流体的液滴 流体; （iii）冷却所述微流体装置的管道中的功能流体段以形成冷却（优选冷冻）的液滴; 和（iv）将液体与冷却的液滴紧密混合，以使所述溶剂离开所述冷却的液滴，从而形成固体珠粒。 还公开了一种用于这种方法的微流体装置。
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公开(公告)号：WO2012042274A1
公开(公告)日：2012-04-05
申请号：PCT/GB2011/051859
申请日：2011-09-30
申请人： Q CHIP LIMITED , PALMER, Daniel , SHADICK, Owen
发明人： PALMER, Daniel , SHADICK, Owen
摘要： A method of forming solid beads, the method comprising: Providing a first liquid comprising a solute and a solvent Forming liquid droplets of the first liquid Contacting the liquid droplets with a second liquid so as to cause the solvent to exit the droplets, thus forming solid beads, the solute comprising a polymer, the concentration of polymer in the first liquid being at least 7% w/v., the solubility of the solvent in the second liquid being at least 5g of solvent per 100ml of second liquid.
摘要翻译： 一种形成固体珠的方法，所述方法包括：提供包含溶质和溶剂的第一液体形成第一液体的液滴将液滴与第二液体接触，以使溶剂离开液滴，从而形成固体 小珠，包含聚合物的溶质，第一液体中聚合物的浓度为至少7％w / v，溶剂在第二液体中的溶解度为每100ml第二液体至少为5g溶剂。
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公开(公告)号：WO2009060202A1
公开(公告)日：2009-05-14
申请号：PCT/GB2008/003750
申请日：2008-11-07
CPC分类号： B01F13/0062 , B01F5/0646 , B01F5/0653 , B01F13/0071 , B01L3/502776 , B01L2300/0816
摘要： A method of sheathing a first fluid by one or more fluids with which the first fluid is immiscible is provided, the method comprising: (i) providing a first fluid(6); (ii) providing second(3)and third(9) fluids with which the first fluid is immiscible; (iii) forming parallel laminar flows of the first (6) and second (3) fluids with the second fluid contacting the first fluid on a first side of the first fluid; (iv) subsequent to step (iii), contacting the third (9) fluid with the second fluid and the first fluid so that the first fluid is sheathed by the second and third fluids. Devices for performing the above-mentioned methods are also provided.
摘要翻译： 提供了一种通过与第一流体不混溶的一种或多种流体包裹第一流体的方法，所述方法包括：（i）提供第一流体（6）; （ii）提供第二流体（3）和第三液体（9），第一流体与其混溶; （iii）形成第一流体（6）和第二流体（3）的平行层流，第二流体在第一流体的第一侧接触第一流体; （iv）在步骤（iii）之后，使第三流体与第二流体和第一流体接触，使得第一流体被第二和第三流体包覆。 还提供了用于执行上述方法的设备。
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公开(公告)号：WO2012042273A1
公开(公告)日：2012-04-05
申请号：PCT/GB2011/051858
申请日：2011-09-30
申请人： Q CHIP LIMITED , PALMER, Daniel , SHADICK, Owen
发明人： PALMER, Daniel , SHADICK, Owen
摘要： An apparatus for making solid beads is provided, the apparatus comprising at least one liquid droplet generator operable to generate droplets comprising a solute dissolved in a solvent, and at least one flow channel for carrying a second liquid, at least one liquid droplet generator and at least one flow channel being spaced relative to one another so that, in use, liquid droplets pass through a gas into a second liquid provided in said flow channel, the solvent being soluble in the second liquid so as to cause the solvent to exit the droplets, thus forming solid beads. A method of preparing solid beads is also provided.
摘要翻译： 提供了一种用于制备实心珠的装置，该装置包括至少一个液滴发生器，其可操作以产生包含溶解在溶剂中的溶质的液滴，以及用于承载第二液体的至少一个流动通道，至少一个液滴发生器 至少一个流动通道相对于彼此间隔开，使得在使用中，液滴通过气体进入设置在所述流动通道中的第二液体中，溶剂可溶于第二液体中，以使溶剂离开液滴 ，从而形成固体珠粒。 还提供了制备固体珠粒的方法。
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公开(公告)号：WO2010004253A3
公开(公告)日：2010-08-05
申请号：PCT/GB2009001492
申请日：2009-06-16
申请人： Q CHIP LTD , PALMER DANIEL , CALDER RICHARD , SHADICK OWEN
发明人： PALMER DANIEL , CALDER RICHARD , SHADICK OWEN
CPC分类号： B01J2/08 , A61K9/1647 , A61K9/1694
摘要： A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.
摘要翻译： 公开了一种制备固体珠粒的方法，所述方法包括：（i）提供微流体装置，其包括在连接区域相遇的载体流体导管和功能流体导管; （ii）提供功能流体的层流，其包括沿着功能流体导管的溶剂和溶质，并且沿着载体流体导管提供载体流体的层流，以便在载体流体流中形成功能流体液滴 ; （iii）冷却所述微流体装置的管道中的功能流体段以形成冷却（优选冷冻）的液滴; 和（iv）将液体与冷却的液滴紧密混合，以使所述溶剂离开所述冷却的液滴，从而形成固体珠粒。 还公开了一种用于这种方法的微流体装置。
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