公开(公告)号：WO03031593A9

公开(公告)日：2004-09-16

申请号：PCT/US0232647

申请日：2002-10-11

Applicant: BIOMOLECULAR PRODUCTS INC ,  YESAIR DAVID W ,  SHAW WALTER A ,  BURGESS STEPHEN W ,  MCKEE TRAVIS

Inventor： YESAIR DAVID W ,  SHAW WALTER A ,  BURGESS STEPHEN W ,  MCKEE TRAVIS

IPC: A61K9/127 ,  A61K47/24 ,  C12P7/64 ,  C12P9/00 ,  C12P13/00 ,  A61K38/00 ,  A61K38/46

CPC classification number: A61K47/24 ,  A61K9/0014 ,  A61K9/1274 ,  C12P7/6481 ,  C12P9/00 ,  C12P13/001 ,  C12P13/06

Abstract: Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.

Abstract translation: 提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。

公开(公告)号：WO2003031593A3

公开(公告)日：2003-04-17

申请号：PCT/US2002/032647

申请日：2002-10-11

Applicant: BIOMOLECULAR PRODUCTS, INC. ,  YESAIR, David, W. ,  SHAW, Walter, A. ,  BURGESS, Stephen, W. ,  McKEE, Travis

Inventor： YESAIR, David, W. ,  SHAW, Walter, A. ,  BURGESS, Stephen, W. ,  McKEE, Travis

IPC: A61K38/00

Abstract: Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A 2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.

公开(公告)号：WO03031593A2

公开(公告)日：2003-04-17

申请号：PCT/US0232647

申请日：2002-10-11

Applicant: BIOMOLECULAR PRODUCTS INC ,  YESAIR DAVID W ,  SHAW WALTER A ,  BURGESS STEPHEN W ,  MCKEE TRAVIS

Inventor： YESAIR DAVID W ,  SHAW WALTER A ,  BURGESS STEPHEN W ,  MCKEE TRAVIS

IPC: A61K9/127 ,  A61K47/24 ,  C12P7/64 ,  C12P9/00 ,  C12P13/00 ,  C12N

CPC classification number: A61K47/24 ,  A61K9/0014 ,  A61K9/1274 ,  C12P7/6481 ,  C12P9/00 ,  C12P13/001 ,  C12P13/06

Abstract: Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.

Abstract translation: 提供了用磷脂酶A2水解固体未受溶解的溶血磷脂酰胆碱的方法。 还公开了制备溶血磷脂酰胆碱，甘油单酯和脂肪酸的脂质基质以及具有特定结构的脂质基质的方法。

公开(公告)号：WO2004069203A2

公开(公告)日：2004-08-19

申请号：PCT/US2004/003562

申请日：2004-01-29

Applicant: CHILDRENS HOSPITAL LOS ANGELES RESEARCH INSTITUTE ,  MAURER, Barry, James ,  REYNOLDS, C., Patrick ,  YESAIR, David, W. ,  MCKEE, Robert, Travis ,  BURGESS, Stephen, W. ,  SHAW, Walter, A.

Inventor： MAURER, Barry, James ,  REYNOLDS, C., Patrick ,  YESAIR, David, W. ,  MCKEE, Robert, Travis ,  BURGESS, Stephen, W. ,  SHAW, Walter, A.

IPC: A61K

CPC classification number: A61K9/0095 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/1617 ,  A61K9/1664 ,  A61K31/167 ,  A23V2250/30 ,  A23V2250/186 ,  A23V2250/192 ,  A23V2250/1846

Abstract: The present invention provides an edible composition for oral delivery of an active agent such as a retinide. The composition comprises, in the form of a dry flowable powder: (a) an active agent such as a retinide; (b) lipid matrix composition; (c) optionally sweetener; (d) flour. Compositions of the invention may be administered per se or mixed with a solid or liquid food carrier, for direct oral consumption by a subject or administration through a feeding tube.

Abstract translation: 本发明提供了用于口服递送活性剂如视黄酸盐的可食用组合物。 组合物包含干燥可流动粉末的形式：（a）活性剂如视黄酸盐; （b）脂质基质组成; （c）任选的甜味剂; （d）面粉。 本发明的组合物本身可以施用或与固体或液体食品载体混合，由受试者或给药通过饲管直接口服消费。

公开(公告)号：WO2004069203A3

公开(公告)日：2005-02-03

申请号：PCT/US2004003562

申请日：2004-01-29

Applicant: LOS ANGELES CHILDRENS HOSPITAL ,  MAURER BARRY JAMES ,  REYNOLDS C PATRICK ,  YESAIR DAVID W ,  MCKEE ROBERT TRAVIS ,  BURGESS STEPHEN W ,  SHAW WALTER A

Inventor： MAURER BARRY JAMES ,  REYNOLDS C PATRICK ,  YESAIR DAVID W ,  MCKEE ROBERT TRAVIS ,  BURGESS STEPHEN W ,  SHAW WALTER A

IPC: A23L1/30 ,  A61K9/00 ,  A61K31/167 ,  A61K47/00

CPC classification number: A61K9/0095 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/1617 ,  A61K9/1664 ,  A61K31/167 ,  A23V2250/30 ,  A23V2250/186 ,  A23V2250/192 ,  A23V2250/1846

Abstract: The present invention provides an edible composition for oral delivery of an active agent such as a retinide. The composition comprises, in the form of a dry flowable powder: (a) an active agent such as a retinide; (b) lipid matrix composition; (c) optionally sweetener; (d) flour. Compositions of the invention may be administered per se or mixed with a solid or liquid food carrier, for direct oral consumption by a subject or administration through a feeding tube.

Abstract translation: 本发明提供了用于口服递送活性剂如视黄酸盐的可食用组合物。 组合物包含干燥可流动粉末的形式：（a）活性剂如视黄酸盐; （b）脂质基质组成; （c）任选的甜味剂; （d）面粉。 本发明的组合物本身可以施用或与固体或液体食品载体混合，由受试者或给药通过饲管直接口服消费。