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    NOVEL HYDRAZIDE CONTAINING TAXANE CONJUGATES
    5.
    发明申请
    NOVEL HYDRAZIDE CONTAINING TAXANE CONJUGATES 审中-公开
    新型含氢氯酸盐包含TAXANE CONJUGATES

    公开(公告)号：WO2010079499A3

    公开(公告)日：2011-09-09

    申请号：PCT/IN2009000112

    申请日：2009-02-12

    申请人： SUN PHARMA ADVANCED RES CO LTD ,  PATEL JITEN RANCHHODBHAI ,  PATEL GOPALKUMAR CHIMANLAL ,  SHETH GAURAV SANJIVKUMAR ,  CHITTURI TRINADHA RAO ,  THENNATI RAJAMANNAR

    发明人： PATEL JITEN RANCHHODBHAI ,  PATEL GOPALKUMAR CHIMANLAL ,  SHETH GAURAV SANJIVKUMAR ,  CHITTURI TRINADHA RAO ,  THENNATI RAJAMANNAR

    IPC分类号： C07D305/14

    CPC分类号： C07D305/14

    摘要： The present invention relates to compounds of formula I or salts thereof, wherein, R1 is selected from the group consisting of hydrogen and R4; R2 is selected from the group consisting of hydrogen, acetyl and R4; R3 is selected from the group consisting of alkyl, -O-alkyl,-NH-alkyl, aryl and heterocyclyl; R4 represents a moiety (A) wherein, X is selected from the group consisting of a single bond, alkylene, alkenylene, alkynylene, arylene or a heterocyclylene moiety; R5 and R6 are same or different and are independently selected from hydrogen, alkyl, aryl or heterocyclyl; or R5 and R6 may form together with the nitrogen atom to which they are attached a heterocyclyl ring system.

    摘要翻译： 本发明涉及式I化合物或其盐，其中R 1选自氢和R 4; R2选自氢，乙酰基和R4; R 3选自烷基，-O-烷基，-NH-烷基，芳基和杂环基; R4表示部分（A），其中X选自单键，亚烷基，亚烯基，亚炔基，亚芳基或亚杂环基; R5和R6相同或不同，独立地选自氢，烷基，芳基或杂环基; 或者R 5和R 6可以与它们所连接的氮原子一起形成杂环基环系。