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    NANOPARTICULATE COMPOSITION
    1.
    发明申请
    NANOPARTICULATE COMPOSITION 审中-公开
    纳米颗粒组合物

    公开(公告)号：WO2016135754A1

    公开(公告)日：2016-09-01

    申请号：PCT/IN2016/050068

    申请日：2016-02-25

    申请人： SUN PHARMA ADVANCED RESEARCH COMPANY LTD

    发明人： BOMMAGANI, Madhusudhan ,  BHOWMICK, Subhas Balaram ,  KANE, Prashant ,  DUBEY, Vaibhav

    IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K9/12 ,  A61K9/51 ,  A61K31/65

    CPC分类号： A61K9/146 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/10 ,  A61K9/122 ,  A61K31/65 ,  A61K47/14 ,  Y02A50/473

    摘要： The present invention relates to a nanoparticulate topical composition comprising (i) nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm, (ii) one or more wetting agent and (iii) a non-aqueous liquid vehicle, wherein the composition is free of water. The present invention also relates to a method of treating acne, rosacea, impetigo or a skin disease caused by a bacteria, by topical application of a nanoparticulate topical composition comprising nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm.

    摘要翻译： 本发明涉及纳米颗粒局部组合物，其包含（i）水溶性和水易感活性成分或其药学上可接受的盐的纳米颗粒，其粒度分布使得90％的颗粒小于1000nm，（ii） 一种或多种润湿剂和（iii）非水液体载体，其中所述组合物不含水。 本发明还涉及通过局部施用包含水溶性和水敏感活性成分或其药学上可接受的盐的纳米颗粒的纳米颗粒局部组合物来治疗由细菌引起的痤疮，红斑痤疮，脓疱病或皮肤病的方法，其具有 使得90％的颗粒小于1000nm的粒度分布。

    QUINOLINE DERIVATIVES AS RENIN INHIBITORS
    2.
    发明申请
    QUINOLINE DERIVATIVES AS RENIN INHIBITORS 审中-公开
    喹诺酮衍生物作为RININ抑制剂

    公开(公告)号：WO2013088452A2

    公开(公告)日：2013-06-20

    申请号：PCT/IN2012/000726

    申请日：2012-11-06

    申请人： SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

    发明人： THENNATI, Rajamannar ,  SAMANTA, Biswajit ,  PAL, Ranjan Kumar ,  KUMBHANI, Anil Savajibhai ,  ADHYAPAK, Jay Prakashchandra ,  AKOLKAR, Nakul P ,  PARMAR, Pravin ,  DUBEY, Megha

    IPC分类号： C07D401/12

    CPC分类号： C07D401/12 ,  C07D405/12 ,  C07D491/04

    摘要： A compound of formula (I), formula (I) or pharmaceutically acceptable salt thereof, as renin inhibitor, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of cardiovascular disorders related to hypertension, in warm-blooded animals. Further the present invention also provides a method for treatment of disorders like congestive heart failure, cardiac hypertrophy, cardiac fibrosis, coronary artery disease, vasculopathy, neuropathy, intraocular hypertension, glaucoma, diabetic nephropathy, abnormal vascular growth, hyperaldosteronism etc.

    摘要翻译： 式（I），式（I）化合物或其药学上可接受的盐作为肾素抑制剂，其制备方法，以及该化合物在制备用于治疗与高血压相关的心血管疾病的药物组合物中的用途 在温血动物中。 此外，本发明还提供了治疗诸如充血性心力衰竭，心脏肥大，心脏纤维化，冠状动脉疾病，血管病变，神经病变，眼内高血压，青光眼，糖尿病肾病，异常血管生长，醛固酮增多症等疾病的方法。