公开(公告)号：WO2006126729A2

公开(公告)日：2006-11-30

申请号：PCT/JP2006/310951

申请日：2006-05-25

Applicant: SHOWA DENKO K.K. ,  SHIBUYA, Akira ,  YOROZUYA, Shinichi ,  SAITO, Makoto

Inventor： SHIBUYA, Akira ,  YOROZUYA, Shinichi ,  SAITO, Makoto

IPC: A61Q5/04 ,  A61K8/49

CPC classification number: A61Q5/04 ,  A61K8/4933

Abstract: Disclosed is an agent for permanent hair waving that can realize permanent hair waving even in the neutral to weakly acidic pH range in which irritation particularly to the skin is not significant. The agent for permanent hair waving includes at least one heterocyclic mercapto compound represented by formula (1): wherein R 1 and R 2 each independently represent a hydrogen atom or an optionally substituted alkyl group having 1 to 5 carbon atoms; X represents -O-, -S-, -NH-, or -NR 3 -; R 3 represents an alkyl group having 1 to 5 carbon atoms; n is an integer of 0 to 2; and, when n is 2, group SH may be attached to any carbon atom of an alkylene group having 2 carbon atoms.

Abstract translation: 公开了即使在特别是对皮肤的刺激不显着的中性至弱酸性pH范围内也能实现永久性头发挥发的药剂。 永久性头发挥发剂包括至少一种由式（1）表示的杂环巯基化合物：其中R 1和R 2各自独立地表示氢原子或任选取代的 具有1至5个碳原子的烷基; X表示-O - ， - S - ， - NH-或-NR 3 - 。 R 3表示具有1至5个碳原子的烷基; n为0〜2的整数， 并且当n为2时，基团SH可以连接到具有2个碳原子的亚烷基的任何碳原子上。

公开(公告)号：WO1988006335A1

公开(公告)日：1988-08-25

申请号：PCT/JP1988000142

申请日：1988-02-12

Applicant: DAI NIPPON INSATSU KABUSHIKI KAISHA ,  KURAMOCHI, Wataru ,  TSURUOKA, Yoshiaki ,  SAITOU, Norikazu ,  SHIBUYA, Akira ,  YAMASHITA, Shuichi

Inventor： DAI NIPPON INSATSU KABUSHIKI KAISHA

IPC: G11B07/00

CPC classification number: G11B19/20 ,  G11B7/0033 ,  G11B7/00745 ,  G11B7/08 ,  G11B7/08505 ,  G11B7/08523 ,  G11B7/0857 ,  G11B7/0904 ,  G11B7/0917 ,  G11B17/34 ,  G11B19/10 ,  G11B19/2018 ,  G11B25/04 ,  G11B33/08 ,  G11B2007/0924

Abstract: A card support means is reciprocally moved by card drive means (109; 511) in a first direction. Optical heads (103; 503; 603) are reciprocally moved by head drive means (108; 507) in a second direction which is at right angles to the first direction. Motors in the drive means are surrounded by metallic vibration isolators (321, 323) and a rubber vibration isolator (322). Position of the optical card is determined by a pressing means (423) for urging the upper surface of the optical card downwardly and by a positioning means (425) capable of contacting the side surface of the optical card. The optical card inserted from the external side is placed in position by a roller means (506) which has a tilted rotary shaft. (505). The optical head (103) is usually controlled by feedback. When the drive speed has dropped, however, the open-loop control is carried out. The optical head is provided with electromagnetic drive means (833, 834) to scan the optical card. Signals read by the optical head are processed by a special binary circuit.

公开(公告)号：WO2009038232A2

公开(公告)日：2009-03-26

申请号：PCT/JP2008067580

申请日：2008-09-19

Applicant: SHOWA DENKO KK ,  SHIBUYA AKIRA ,  AOKI HIDEMASA

Inventor： SHIBUYA AKIRA ,  AOKI HIDEMASA

IPC: C07C319/04 ,  C07B45/06 ,  C07C323/54 ,  C07C323/56 ,  C07C323/61

CPC classification number: C07C319/04 ,  C07B45/06 ,  C07C2601/10 ,  C07C2601/16 ,  C07C323/52 ,  C07C323/56

Abstract: The invention relates to a method for efficiently producing ß-mercaptocarboxylic acids using a solid acid catalyst such as zeolite, which product corresponds to respective starting materials selected from a, ß-unsaturated carboxylic acids (a, ß-unsaturated carboxylic acid, a, ß-unsaturated carboxylic acid ester, ex, ß-unsaturated amide, a, ß-unsaturated aldehide and a, ß-unsaturated ketone) and hydrogen sulfides (hydrogen sulfide, sulfide salt and hydrosulfide salt), wherein a solvent compatible with water is used in the reaction. According to the invention, ß-mercaptocarboxylic acids which are useful as additives in synthetic materials for pharmaceutical or agricultural agents and in polymer compounds can be industrially produced efficiently by using easily available a, ß-unsaturated carboxylic acid (such as crotonic acid) at high yield.

Abstract translation: 本发明涉及一种使用固体酸催化剂如沸石有效生产β-巯基羧酸的方法，该产物对应于选自以下的各种起始物质：β-不饱和羧酸（a，β-不饱和羧酸，a，ß 不饱和酰胺，α，β-不饱和醛和a，β-不饱和酮）和硫化氢（硫化氢，硫化物盐和氢硫化物盐），其中使用与水相容的溶剂 反应。 根据本发明，可用作药物或农药合成材料和聚合物化合物的合成材料中的添加剂的β-巯基羧酸可以通过在高温下使用容易获得的α，β-不饱和羧酸（如巴豆酸）有效地生产 产量。

公开(公告)号：WO2009113711A1

公开(公告)日：2009-09-17

申请号：PCT/JP2009/055213

申请日：2009-03-11

Applicant: SHOWA DENKO K.K. ,  AOKI, Hidemasa ,  KUROIWA, Akio ,  SHIBUYA, Akira

Inventor： AOKI, Hidemasa ,  KUROIWA, Akio ,  SHIBUYA, Akira

IPC: C07C319/04

CPC classification number: C07C319/04 ,  C07C323/56 ,  C07C323/52

Abstract: An object of the present invention is to provide a method for industrially producing beta-mercapto carboxylic acids that are useful as synthetic raw materials for medicines and agrochemicals or as additives for polymer compounds from easily available alpha,beta-unsaturated carboxylic acids in high yields and productivity. The present invention is characterized in that a solvent having an amide group and represented by the formula (1) is used when the alpha,beta-unsaturated carboxylic acids are reacted with hydrogen sulfides to produce the beta-mercapto carboxylic acids. Particularly, it is more preferable to carry out the reaction at a pH range of 6.0 to 8.5: (In the formula (1), R 1 represents any one of a hydrogen atom, an alkoxy group having 1 to 5 carbon atoms, an alkyl group having 1 to 5 carbon atoms, an amino group, and an alkylamino group having 1 to 5 carbon atoms; R 2 and R 3 each represents independently any one of a hydrogen atom and an alkyl group having 1 to 5 carbon atoms; when both R 2 and R 3 are not a hydrogen atom, R 2 and R 3 may together form a ring structure through an alkylene group; and when both R 1 and R 2 are not a hydrogen atom, R 1 and R 2 may form a ring structure through an alkylene group).

Abstract translation: 本发明的目的是提供一种工业生产β-巯基羧酸的方法，其可用作药物和农用化学品的合成原料或作为高收率的易于获得的α，β-不饱和羧酸的聚合物化合物的添加剂，以及 生产率。 本发明的特征在于当α，β-不饱和羧酸与硫化氢反应生成β-巯基羧酸时，使用具有酰胺基并由式（1）表示的溶剂。 特别优选在6.0〜8.5的pH范围进行反应（式（1）中，R 1表示氢原子，碳原子数1〜5的烷氧基，烷基 具有1至5个碳原子，氨基和具有1至5个碳原子的烷基氨基; R 2和R 3各自独立地表示氢原子和具有1至5个碳原子的烷基中的任一个;当R 2和R 3均为 不是氢原子，R2和R3可以一起通过亚烷基形成环结构;当R1和R2都不是氢原子时，R1和R2可以通过亚烷基形成环结构）。

公开(公告)号：WO2006083031A1

公开(公告)日：2006-08-10

申请号：PCT/JP2006/302301

申请日：2006-02-03

Applicant: SHOWA DENKO K.K. ,  SHIBUYA, Akira ,  SAITO, Makoto

Inventor： SHIBUYA, Akira ,  SAITO, Makoto

IPC: A61Q5/04 ,  A61K8/46

CPC classification number: A61K8/46 ,  A61Q5/04

Abstract: A hair relaxer includes at least one specific mercapto compound such as 2-methoxyethyl 3-mercaptopropionate, 2-mercapto-4-butanolide and 2-mercapto-4-butyrolactam. The hair relaxer can achieve an excellent effect of shaping and relaxing hair over a wide range of pH values from weak acidity to weak alkalinity. In particular, the hair relaxer displays a more superior hair shaping and relaxing performance in a weakly acidic to neutral pH range. Consequently, the hair relaxer can drastically reduce the damage to the hair and skin and can reliably perform straightening, uncurling, curling and other hair processing.

Abstract translation: 头发松弛剂包括至少一种特定的巯基化合物，例如3-巯基丙酸2-甲氧基乙酯，2-巯基-4-丁醇酯和2-巯基-4-丁内酰胺。 头发松弛剂可以在从弱酸性到弱碱性的广泛pH值范围内实现成型和松弛头发的优异效果。 特别地，头发松弛剂在弱酸性至中性pH范围内显示出更优异的头发成型和松弛性能。 因此，头发松弛剂可以大大降低对头发和皮肤的损伤，并可以可靠地进行矫直，卷曲，卷曲和其它头发处理。

公开(公告)号：WO2005115326A1

公开(公告)日：2005-12-08

申请号：PCT/JP2005/010309

申请日：2005-05-31

Applicant: SHOWA DENKO K.K. ,  SHIBUYA, Akira ,  KATOH, Eiko ,  KAMACHI, Motoaki ,  AOKI, Hirobumi

Inventor： SHIBUYA, Akira ,  KATOH, Eiko ,  KAMACHI, Motoaki ,  AOKI, Hirobumi

IPC: A61K7/48

CPC classification number: A61K8/365 ,  A61K8/44 ,  A61K8/676 ,  A61K8/678 ,  A61K31/195 ,  A61Q19/06

Abstract: The invention provides a slimming skin external preparation and a cosmetic that contain a carnitine derivative having excellent skin affinity and percutaneous absorption properties and capable of enhancing the fat metabolism, and that can treat, reduce or prevent the obesity by functioning as a lipolytic agent to enhance the fat metabolism of general or local subcutaneous fat tissues. The slimming skin external preparation contains a particular carnitine derivative such as a cylcarnitines and alcohol carnitine esters and preferably other slimming and skin-care ingredients.

Abstract translation: 本发明提供了一种减肥皮肤外用剂和化妆品，其含有具有优异的皮肤亲和性和经皮吸收性能并能够增强脂肪代谢的肉碱衍生物，并且可以通过用作促脂肪分解剂来治疗，减少或预防肥胖症 一般或局部皮下脂肪组织的脂肪代谢。 减肥皮肤外用制剂含有特定的肉碱衍生物，如椰子油和酒精肉碱酯，优选其它减肥和护肤成分。

公开(公告)号：WO2009038232A3

公开(公告)日：2009-03-26

申请号：PCT/JP2008/067580

申请日：2008-09-19

Applicant: SHOWA DENKO K.K. ,  SHIBUYA, Akira ,  AOKI, Hidemasa

Inventor： SHIBUYA, Akira ,  AOKI, Hidemasa

IPC: C07C319/04 ,  C07C323/56 ,  C07C323/54 ,  C07C323/61 ,  C07B45/06

Abstract: The invention relates to a method for efficiently producing β-mercaptocarboxylic acids using a solid acid catalyst such as zeolite, which product corresponds to respective starting materials selected from α, β-unsaturated carboxylic acids (α, β-unsaturated carboxylic acid, a, β-unsaturated carboxylic acid ester, ex, β-unsaturated amide, a, β-unsaturated aldehide and α, β-unsaturated ketone) and hydrogen sulfides (hydrogen sulfide, sulfide salt and hydrosulfide salt), wherein a solvent compatible with water is used in the reaction. According to the invention, β-mercaptocarboxylic acids which are useful as additives in synthetic materials for pharmaceutical or agricultural agents and in polymer compounds can be industrially produced efficiently by using easily available a, β-unsaturated carboxylic acid (such as crotonic acid) at high yield.

公开(公告)号：WO2006126729A3

公开(公告)日：2007-02-08

申请号：PCT/JP2006310951

申请日：2006-05-25

Applicant: SHOWA DENKO KK ,  SHIBUYA AKIRA ,  YOROZUYA SHINICHI ,  SAITO MAKOTO

Inventor： SHIBUYA AKIRA ,  YOROZUYA SHINICHI ,  SAITO MAKOTO

IPC: A61Q5/04 ,  A61K8/49

CPC classification number: A61Q5/04 ,  A61K8/4933

Abstract: Disclosed is an agent for permanent hair waving that can realize permanent hair waving even in the neutral to weakly acidic pH range in which irritation particularly to the skin is not significant. The agent for permanent hair waving includes at least one heterocyclic mercapto compound represented by formula (1): wherein R 1 and R 2 each independently represent a hydrogen atom or an optionally substituted alkyl group having 1 to 5 carbon atoms; X represents -O-, -S-, -NH-, or -NR 3 -; R 3 represents an alkyl group having 1 to 5 carbon atoms; n is an integer of 0 to 2; and, when n is 2, group SH may be attached to any carbon atom of an alkylene group having 2 carbon atoms.

Abstract translation: 公开了即使在特别是对皮肤的刺激不显着的中性至弱酸性pH范围内也能实现永久性头发挥发的药剂。 永久性头发挥发剂包括至少一种由式（1）表示的杂环巯基化合物：其中R 1和R 2各自独立地表示氢原子或任选取代的 具有1至5个碳原子的烷基; X表示-O - ， - S - ， - NH-或-NR 3 - 。 R 3表示具有1至5个碳原子的烷基; n为0〜2的整数， 并且当n为2时，基团SH可以连接到具有2个碳原子的亚烷基的任何碳原子上。

公开(公告)号：WO2006121214A3

公开(公告)日：2006-11-16

申请号：PCT/JP2006/309982

申请日：2006-05-12

Applicant: SHOWA DENKO K.K. ,  SHIBUYA, Akira ,  KAMACHI, Motoaki

Inventor： SHIBUYA, Akira ,  KAMACHI, Motoaki

IPC: A61Q5/04 ,  A61Q5/10 ,  A61K8/49 ,  A61Q5/06

Abstract: A permanent waving agent is capable of permanent waving and coloring hair simultaneously. The permanent waving agent includes: (i) a perming first agent including at least one compound represented by Formula (1) below, and an acid dye and/or an oxidation dye: wherein X is a structure selected from the group consisting of -O-, -S-, -NH- and -NR 1 -; R 1 is an alkyl group of 1 to 6 carbon atoms; R 2 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms; Y is an oxygen atom or a sulfur atom; and R is a divalent organic residue optionally having a mercapto group; and (ii) a perming second agent including an oxidizing agent.

公开(公告)号：WO2006121214A2

公开(公告)日：2006-11-16

申请号：PCT/JP2006309982

申请日：2006-05-12

Applicant: SHOWA DENKO KK ,  SHIBUYA AKIRA ,  KAMACHI MOTOAKI

Inventor： SHIBUYA AKIRA ,  KAMACHI MOTOAKI

CPC classification number: A61K8/4913 ,  A61K8/447 ,  A61K8/4933 ,  A61K8/4973 ,  A61K2800/884 ,  A61Q5/04 ,  A61Q5/10

Abstract: A permanent waving agent is capable of permanent waving and coloring hair simultaneously. The permanent waving agent includes:(i) a perming first agent including at least one compound represented by Formula (1) below, and an acid dye and/or an oxidation dye: wherein X is a structure selected from the group consisting of -O-, -S-, -NH- and -NR 1 -; R 1 is an alkyl group of 1 to 6 carbon atoms; R 2 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms; Y is an oxygen atom or a sulfur atom; and R is a divalent organic residue optionally having a mercapto group; and(ii) a perming second agent including an oxidizing agent.

Abstract translation: 永久性挥发剂能够同时烫发和着色头发。 永久性挥发剂包括：（i）包含至少一种由下式（1）表示的化合物的烫发第一剂和酸性染料和/或氧化染料：其中X是选自-O - ， - S - ， - NH-和-NR 1 - 。 R 1是1至6个碳原子的烷基; R 2是氢原子或1〜6个碳原子的烷基; Y是氧原子或硫原子; 并且R是任选具有巯基的二价有机残基; 和（ii）包含氧化剂的烫发第二剂。