公开(公告)号：WO0130413A9

公开(公告)日：2002-08-08

申请号：PCT/US0041524

申请日：2000-10-24

Applicant: ALSIUS CORP ,  PHAM NORA TRAN ,  SHIMADA LYNN M ,  EVANS SCOTT M ,  WALKER BLAIR D

Inventor： PHAM NORA TRAN ,  SHIMADA LYNN M ,  EVANS SCOTT M ,  WALKER BLAIR D

IPC: A61B17/00 ,  A61B18/00 ,  A61F7/12 ,  A61M1/36 ,  A61M5/44 ,  A61M29/00

CPC classification number: A61F7/123 ,  A61B2018/00011 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44

Abstract: A system for controlling a patient temperature uses a central venous line catheter (100) having axially spaced distal and proximal heat exchange balloons (102/104). The central venous line catheter (100) is provided with one or more lumens (128) for providing access to the central blood supply of the patient, and with additional lumens (106/108) for communicating heat exchange fluid to the balloons (102/104). Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit (50) comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set (120/122) transports the heat exchange fluid between the central venous line (100) and the temperature control unit (50), with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract translation: 用于控制患者温度的系统使用具有轴向间隔开的远端和近端热交换球囊（102/104）的中心静脉导管（100）。 中心静脉导管（100）设置有一个或多个腔（128），用于提供对患者的中心血液供应的通路，以及用于将热交换流体传送到气囊（102 / 104）。 热交换流体温度通过反馈回路来控制，其中感测患者温度并用于控制包括与热交换流体热交换关系的加热装置和/或冷却装置的温度控制单元（50）。 管道组（120/122）在中心静脉管线（100）和温度控制单元（50）之间输送热交换流体，其中泵用于将流体循环在系统中的封闭流体回路中。

公开(公告)号：WO0062837A2

公开(公告)日：2000-10-26

申请号：PCT/US0010494

申请日：2000-04-19

Applicant: ALSIUS CORP ,  WALKER BLAIR D ,  EVANS SCOTT M ,  BALDING DAVID P ,  HALLAM GREGG ,  SHIMADA LYNN M

Inventor： WALKER BLAIR D ,  EVANS SCOTT M ,  BALDING DAVID P ,  HALLAM GREGG ,  SHIMADA LYNN M

IPC: A61M25/00 ,  A61B18/00 ,  A61F7/00 ,  A61F7/12 ,  A61M1/36 ,  A61M5/44 ,  A61M

CPC classification number: A61F7/123 ,  A61B2018/00011 ,  A61F7/12 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/00 ,  A61M25/0009 ,  A61M2205/36

Abstract: This invention is a catheter (110) using multiple hollow fibers to carry a heating/cooling fluid employs fiber (108) spreading features to improve heat transfer, and prevent clotting of body fluids within which the catheter is immersed. The catheter includes an outer tube (102) surrounding an inner tube (104). The inner tube conveys fluids in one direction, a passageway between inner, and outer tubes conveying fluids in the opposite direction. The catheter's distal end is closed, but the proximal end is open to permit introduction of a heating or cooling fluid into the inner tube, and withdrawal of the fluid from the passageway between the inner, and outer tubes. At the tubes' distal end resides a proximal fluid transfer housing (106) coupled to multiple hollow heat exchange fibers. The distal ends of these fibers may be commonly connected to a distal fluid transfer housing (110), and optional reservoir (112). Actuating structure(s) may be included to spread the fibers.

Abstract translation: 本发明是使用多个中空纤维承载加热/冷却流体的导管（110），该加热/冷却流体采用纤维（108）扩散特征以改善热传递，并且防止导管浸入其中的体液的凝结。 导管包括围绕内管（104）的外管（102）。 内管在一个方向上输送流体，内管和外管之间的通道沿相反方向输送流体。 导管的远端是封闭的，但是近端是敞开的，以允许将加热或冷却流体引入内管，并且将流体从内管和外管之间的通道中取出。 在管的远端存在耦合到多个中空热交换纤维的近端流体转移壳体（106）。 这些纤维的远端可以共同连接到远端流体转移壳体（110）和任选的储存器（112）。 可以包括致动结构以展开纤维。

公开(公告)号：WO2002058606A1

公开(公告)日：2002-08-01

申请号：PCT/US2001/002431

申请日：2001-01-24

Applicant: ALSIUS CORPORATION ,  SHIMADA, Lynn, M. ,  WORTHERN, William, J. ,  EVANS, Scott, M. ,  LUO, Xia ,  PECOR, Robert ,  WALKER, Blair

Inventor： SHIMADA, Lynn, M. ,  WORTHERN, William, J. ,  EVANS, Scott, M. ,  LUO, Xia ,  PECOR, Robert ,  WALKER, Blair

IPC: A61F7/12

CPC classification number: A61M25/10 ,  A61F7/123 ,  A61F2007/126 ,  A61M39/06 ,  A61M2205/366

Abstract: An introducer sheath for a central venous catheter includes a sheath body and a temperature sensor mounted distally on the body. Either the catheter or sheath has a heat exchange region through which coolant is circulated to effect heat exchange with the body, with the coolant temperature being controlled in response to signals from the temperature sensor. Arterial dialysis heat exchange catheters and jugular bulb heat exchange catheters are also disclosed.

Abstract translation: 用于中心静脉导管的导引鞘包括护套主体和安装在身体上的温度传感器。 导管或护套都具有热交换区域，冷却剂通过该热交换区域循环以与身体进行热交换，其中冷却剂温度响应于来自温度传感器的信号而被控制。 还公开了动脉透析换热导管和颈小管热交换导管。

公开(公告)号：WO0062837A9

公开(公告)日：2002-03-14

申请号：PCT/US0010494

申请日：2000-04-19

Applicant: ALSIUS CORP ,  WALKER BLAIR D ,  EVANS SCOTT M ,  BALDING DAVID P ,  HALLAM GREGG ,  SHIMADA LYNN M

Inventor： WALKER BLAIR D ,  EVANS SCOTT M ,  BALDING DAVID P ,  HALLAM GREGG ,  SHIMADA LYNN M

IPC: A61M25/00 ,  A61B18/00 ,  A61F7/00 ,  A61F7/12 ,  A61M1/36 ,  A61M5/44 ,  A61B18/04 ,  F28F1/00 ,  H05B7/12

CPC classification number: A61F7/123 ,  A61B2018/00011 ,  A61F7/12 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44 ,  A61M25/00 ,  A61M25/0009 ,  A61M2205/36

Abstract: This invention is a catheter (110) using multiple hollow fibers to carry a heating/cooling fluid employs fiber (108) spreading features to improve heat transfer, and prevent clotting of body fluids within which the catheter is immersed. The catheter includes an outer tube (102) surrounding an inner tube (104). The inner tube conveys fluids in one direction, a passageway between inner, and outer tubes conveying fluids in the opposite direction. The catheter's distal end is closed, but the proximal end is open to permit introduction of a heating or cooling fluid into the inner tube, and withdrawal of the fluid from the passageway between the inner, and outer tubes. At the tubes' distal end resides a proximal fluid transfer housing (106) coupled to multiple hollow heat exchange fibers. The distal ends of these fibers may be commonly connected to a distal fluid transfer housing (110), and optional reservoir (112). Actuating structure(s) may be included to spread the fibers.

Abstract translation: 本发明是使用多个中空纤维承载加热/冷却流体的导管（110），该加热/冷却流体采用纤维（108）扩散特征以改善热传递，并且防止导管浸入其中的体液的凝结。 导管包括围绕内管（104）的外管（102）。 内管在一个方向上输送流体，内管和外管之间的通道沿相反方向输送流体。 导管的远端是封闭的，但是近端是敞开的，以允许将加热或冷却流体引入内管，并且将流体从内管和外管之间的通道中取出。 在管的远端存在耦合到多个中空热交换纤维的近端流体转移壳体（106）。 这些纤维的远端可以共同连接到远端流体转移壳体（110）和任选的储存器（112）。 可以包括致动结构以展开纤维。

公开(公告)号：WO2001030413A3

公开(公告)日：2001-05-03

申请号：PCT/US2000/041524

申请日：2000-10-24

Applicant: ALSIUS CORPORATION ,  PHAM, Nora, Tran ,  SHIMADA, Lynn, M. ,  EVANS, Scott, M. ,  WALKER, Blair, D.

Inventor： PHAM, Nora, Tran ,  SHIMADA, Lynn, M. ,  EVANS, Scott, M. ,  WALKER, Blair, D.

IPC: A61M29/00

Abstract: A system for controlling a patient temperature uses a central venous line catheter (100) having axially spaced distal and proximal heat exchange balloons (102/104). The central venous line catheter (100) is provided with one or more lumens (128) for providing access to the central blood supply of the patient, and with additional lumens (106/108) for communicating heat exchange fluid to the balloons (102/104). Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit (50) comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set (120/122) transports the heat exchange fluid between the central venous line (100) and the temperature control unit (50), with a pump serving to circulate the fluid in a closed fluid circuit in the system.

公开(公告)号：WO0130413A2

公开(公告)日：2001-05-03

申请号：PCT/US0041524

申请日：2000-10-24

Applicant: ALSIUS CORP ,  PHAM NORA TRAN ,  SHIMADA LYNN M ,  EVANS SCOTT M ,  WALKER BLAIR D

Inventor： PHAM NORA TRAN ,  SHIMADA LYNN M ,  EVANS SCOTT M ,  WALKER BLAIR D

IPC: A61B17/00 ,  A61B18/00 ,  A61F7/12 ,  A61M1/36 ,  A61M5/44 ,  A61M

CPC classification number: A61F7/123 ,  A61B2018/00011 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/44

Abstract: A system for controlling a patient temperature uses a central venous line catheter (100) having axially spaced distal and proximal heat exchange balloons (102/104). The central venous line catheter (100) is provided with one or more lumens (128) for providing access to the central blood supply of the patient, and with additional lumens (106/108) for communicating heat exchange fluid to the balloons (102/104). Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit (50) comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set (120/122) transports the heat exchange fluid between the central venous line (100) and the temperature control unit (50), with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract translation: 用于控制患者体温的系统使用具有轴向间隔开的远端和近端热交换球囊（102/104）的中心静脉导管（100）。 中心静脉导管（100）设置有一个或多个腔（128），用于提供对患者的中央血液供应的通路，以及用于将热交换流体传送到气囊（102/108）的附加腔（106/108） 104）。 热交换流体温度通过反馈回路来控制，其中感测患者温度并用于控制包括与热交换流体热交换关系的加热装置和/或冷却装置的温度控制单元（50）。 管组（120/122）在中央静脉管路（100）和温度控制单元（50）之间输送热交换流体，其中泵用于使流体循环在系统中的封闭流体回路中。