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1.发明申请
公开(公告)号：WO2001050885A3
公开(公告)日：2001-07-19
申请号：PCT/US2001/001021
申请日：2001-01-11
Applicant: ONCOLOGY SCIENCES CORPORATION , SLAGA, Tom , ZHAO, Jifu , AGRAWAL, Rajesh
Inventor： SLAGA, Tom , ZHAO, Jifu , AGRAWAL, Rajesh
Abstract: A process for increasing the levels of polyphenolic acid release into coffee which is brewed from beans which are bathed in an aqueous, basic solution shortly after roasting. The same process is applied to other polyphenolics containing beverage substrates, including teas. The bathing of beverage substrates (coffee beans and tea leaves, for example) with the aqueous agent does not adversely change the taste of the produced beverage, and, in fact, in the case of coffee, such process actually extends the apparent freshness of coffee by inhibiting in the condensation of tannins in the coffee brew, thereby providing, not only the health benefits of the elevated levels of polyphenols, but a means to extend the freshness of the brewed beverage.
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2.发明申请AGENTS AND METHODS FOR THE PREVENTION OF INITIAL ONSET OF CANCERS, THE TREATMENT OF CANCERS, AND THE RECURRENCE OF EXISTING CANCERS 审中-公开预防癌症发病初期，癌症治疗和现有癌症复发的代理和方法
公开(公告)号：WO0170093A3
公开(公告)日：2009-06-11
申请号：PCT/US0108718
申请日：2001-03-19
Applicant: ONCOLOGY SCIENCES CORP , SLAGA TOM , KUMAR ADDANKI , ALWORTH WILLIAM
Inventor： SLAGA TOM , KUMAR ADDANKI , ALWORTH WILLIAM
IPC: C07J1/00 , A61K31/085 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/567 , A61K31/58 , A61P35/00 , C07J41/00
CPC classification number: A61K31/085 , A61K31/565 , A61K31/566 , A61K31/567 , A61K31/58 , A61K2300/00
Abstract: The use of 2-methoxyestradiol, analogues of 2-methoxyestradiol, their method of synthesis and therapeutic use and the use of combinations of the 2-methoxyestradiol and its anslogues, with or without synergistic compounds (namely eugenol), all in the prevention of initial onset cancers, treatment of existing cancers, and the recurrence of previously existing cancers.
Abstract translation: 使用2-甲氧基雌二醇，2-甲氧基雌二醇的类似物，其合成方法和治疗用途以及使用或不与协同化合物（即丁子香酚）联合使用的2-甲氧基雌二醇及其成分的组合，都在预防初始 发病的癌症，治疗现有的癌症以及以前存在的癌症的复发。
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3.发明申请EUGENOL, OPTIONALLY IN COMBINATION WITH 2-METHOXYESTRADIOL, AS A CANCER CHEMOPREVENTATIVE AGENT 审中-公开EUGENOL选择性地与2-甲氧基吡咯烷酮（作为癌症化学药剂）组合
公开(公告)号：WO2002062348A1
公开(公告)日：2002-08-15
申请号：PCT/US2002/002826
申请日：2002-02-01
Applicant: ONCOLOGY SCIENCES CORPORATION , SLAGA, Tom , KUMAR, Addanki , ALWORTH, William
Inventor： SLAGA, Tom , KUMAR, Addanki , ALWORTH, William
IPC: A61K31/565
CPC classification number: A61K31/565 , A61K31/085 , A61K31/567 , A61K2300/00
Abstract: The use of eugenol, alone and in combination with 2-methoxyestradiol (2-ME) in the context of prostate cancer prophylaxes and treatment.
Abstract translation: 在前列腺癌预防和治疗的情况下，使用丁香酚单独和与2-甲氧基雌二醇（2-ME）组合使用。
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Patent Agency Ranking4.发明申请AGENTS AND METHODS FOR THE PREVENTION OF INITIAL ONSET AND RECURRENCE OF EXISTING CANCERS 审中-公开用于预防现有癌症的初始突发和复发的代理和方法
公开(公告)号：WO2002072021A2
公开(公告)日：2002-09-19
申请号：PCT/US2002/007445
申请日：2002-03-13
Applicant: ONCOLOGY SCIENCES CORPORATION , SLAGA, Tom , KUMAR, Addanki , ALWORTH, William
Inventor： SLAGA, Tom , KUMAR, Addanki , ALWORTH, William
IPC: A61K
CPC classification number: A61K31/085 , A61K31/565 , A61K31/566 , A61K31/567 , A61K31/58 , A61K2300/00
Abstract: The use of 2-methoxyestradiol, analogues of 2-methosyestradiol, their method of synthesis and therapeutic use, and the use of combinations of the 2 methoxyestradiol and its analogues with synergistic compounds (namely eugenol), all in the prevention of initial onset cancers and the recurrence of previously existing cancers.
Abstract translation: 使用2-甲氧基雌二醇，2-甲硫基雌二醇的类似物，其合成方法和治疗用途，以及使用2-甲氧基雌二醇及其类似物与协同化合物（即丁子香酚）的组合，全部用于预防初始发病的癌症和 先前存在的癌症复发。
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5.发明申请METHOD AND COMPOSITION OF NOVEL COMPOUNDS FOR THE THERAPY AND TARGETING OF THE PRIMARY MODALITIES OF CANCER CELL PROLIFERATION AND HOMEOSTASIS 审中-公开新型化合物治疗癌症细胞增殖和归巢的主要模式的治疗方法与组合
公开(公告)号：WO2002062347A1
公开(公告)日：2002-08-15
申请号：PCT/US2002/002827
申请日：2002-02-01
Applicant: ONCOLOGY SCIENCES CORPORATION , SLAGA, Tom , KUMAR, Addanki , ALWORTH, William
Inventor： SLAGA, Tom , KUMAR, Addanki , ALWORTH, William
IPC: A61K31/56
CPC classification number: A61K31/085 , A61K31/565 , A61K31/567 , A61K2300/00
Abstract: The invention is of both a composition and method for inhibiting the proliferation of cancerous cells. The composition is, and the method is based on the use of a composition consisting (among active ingredients) substantially of 2-methoxyestradiol and/or one of a number of analogues thereof. The present inventors have demonstrated beyond serious doubt that these compounds have a pronounced effect in inhibiting the proliferation of cancerous cells and, therefore, provide a desperately needed stepping stone for advancing toward meaningful treatment of cancer.
Abstract translation: 本发明既是抑制癌细胞增殖的组合物和方法。 该组合物是，并且该方法基于使用基本上由2-甲氧基雌二醇和/或其多个类似物之一组成的组合物（在活性成分中）。 本发明人已经证明，这些化合物在抑制癌细胞增殖方面具有明显的效果，因此，提供了一种迫切需要的踏脚石，用于推进癌症的有意义的治疗。
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6.发明申请
公开(公告)号：WO2002072021A3
公开(公告)日：2002-09-19
申请号：PCT/US2002/007445
申请日：2002-03-13
Applicant: ONCOLOGY SCIENCES CORPORATION , SLAGA, Tom , KUMAR, Addanki , ALWORTH, William
Inventor： SLAGA, Tom , KUMAR, Addanki , ALWORTH, William
IPC: C07J1/00
Abstract: The use of 2-methoxyestradiol, analogues of 2-methosyestradiol, their method of synthesis and therapeutic use, and the use of combinations of the 2 methoxyestradiol and its analogues with synergistic compounds (namely eugenol), all in the prevention of initial onset cancers and the recurrence of previously existing cancers.
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7.发明申请METHOD AND COMPOSITION FOR INHIBITING THE INCIDENCE AND PROLIFERATION OF NERVOUS SYSTEM AND BRAIN CANCER CELLS 审中-公开用于抑制神经系统和脑癌细胞的发生和增殖的方法和组合物
公开(公告)号：WO2002062349A1
公开(公告)日：2002-08-15
申请号：PCT/US2002/002828
申请日：2002-02-01
Applicant: ONCOLOGY SCIENCES CORPORATION , SLAGA, Tom , KUMAR, Addanki , ALWORTH, William
Inventor： SLAGA, Tom , KUMAR, Addanki , ALWORTH, William
IPC: A61K31/566
CPC classification number: A61K31/565 , A61K31/085 , A61K31/567 , A61K2300/00
Abstract: The invention is of both a composition and method for inhibiting the proliferation of cancerous cells, and brain and nervous system cells in particular. The composition is, and the method is based on the use of a composition consisting (among active ingredients) substantially of 2-methoxyestradiol and/or one of a number of analogues thereof. The present inventors have demonstrated beyond serious doubt that these compounds have a pronounced effect in inhibiting the proliferation of cancerous brain and nervous system cells and, therefore, provide a desperately needed stepping stone for advancing toward meaningful treatment of brain and nervous system cancer.
Abstract translation: 本发明既是抑制癌细胞增殖，特别是脑和神经系统细胞的组合物和方法。 该组合物是，并且该方法基于使用基本上由2-甲氧基雌二醇和/或其多个类似物之一组成的组合物（在活性成分中）。 本发明人已经证明，这些化合物在抑制癌性脑和神经系统细胞的增殖方面具有显着的效果，因此，提供了迫切需要的踏脚石，用于有意义地治疗脑和神经系统癌症。
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8.发明申请
公开(公告)号：WO0150885A2
公开(公告)日：2001-07-19
申请号：PCT/US0101021
申请日：2001-01-11
Applicant: ONCOLOGY SCIENCES CORP , SLAGA TOM , ZHAO JIFU , AGRAWAL RAJESH
Inventor： SLAGA TOM , ZHAO JIFU , AGRAWAL RAJESH
Abstract: A process for increasing the levels of polyphenolic acid release into coffee which is brewed from beans which are bathed in an aqueous, basic solution shortly after roasting. The same process is applied to other polyphenolics containing beverage substrates, including teas. The bathing of beverage substrates (coffee beans and tea leaves, for example) with the aqueous agent does not adversely change the taste of the produced beverage, and, in fact, in the case of coffee, such process actually extends the apparent freshness of coffee by inhibiting in the condensation of tannins in the coffee brew, thereby providing, not only the health benefits of the elevated levels of polyphenols, but a means to extend the freshness of the brewed beverage.
Abstract translation: 一种将多酚酸释放到咖啡中的方法，该咖啡从焙烧后不久浸泡在水性碱性溶液中的豆制成。 相同的方法应用于含有饮料底物（包括茶）的其它多酚类物质。 饮料基质（例如咖啡豆和茶叶）与含水剂的洗澡不会不利地改变生产的饮料的味道，实际上，在咖啡的情况下，这种方法实际上延长了咖啡的表观新鲜度 通过抑制咖啡冲泡中的单宁酸的冷凝，从而不仅提供了多酚的高水平的健康益处，而且提供了延长酿造的饮料的新鲜度的手段。
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