公开(公告)号：WO2008155658A3

公开(公告)日：2008-12-24

申请号：PCT/IB2008/002109

申请日：2008-06-18

Applicant: INSTITUTE OF ZOOLOGY OF THE SLOVAK ACADEMY OF SCIENCES ,  NATIONAL UNIVERSITY OF SINGAPORE ,  KAZIMIROVA, Maria ,  KINI, R. Manjunatha ,  KOH, Cho Yeow

Inventor： KAZIMIROVA, Maria ,  KINI, R. Manjunatha ,  KOH, Cho Yeow

IPC: A61K38/36 ,  A61K38/57 ,  A61P7/02

Abstract: The invention relates to thrombin inhibitors derived from the salivary glands of haematophagous arthropods and in particular to bivalent and trivalent thrombin inhibitors that act by interacting with thrombin at two or three different sites.

公开(公告)号：WO2020245230A1

公开(公告)日：2020-12-10

申请号：PCT/EP2020/065396

申请日：2020-06-03

Applicant: DANMARKS TEKNISKE UNIVERSITET ,  SLOVAK ACADEMY OF SCIENCES ,  FRIEDRICH-ALEXANDER UNIVERSITÄT ERLANGEN-NÜRNBERG

Inventor： PLAKHOTNYUK, Maksym ,  HANSEN, Ole ,  ANJA, Boisen ,  RINDZEVICIUS, Tomas ,  KUNDRATA, Ivan ,  FRÖHLICH, Karol ,  BACHMANN, Julien

IPC: C23C16/04 ,  C23C16/455 ,  B33Y10/00 ,  B33Y30/00 ,  B29C64/159 ,  B29C64/209

Abstract: The invention relates to an atomic layer process printer for material deposition, etching and/or cleaning on an atomic scale in a selective area. The invention further relates to a method for material deposition, etching and/or cleaning on an atomic scale in a selective area using the atomic layer process printer.

公开(公告)号：WO2016204696A1

公开(公告)日：2016-12-22

申请号：PCT/SG2016/050278

申请日：2016-06-17

Applicant: NATIONAL UNIVERSITY OF SINGAPORE ,  INSTITUTE OF ZOOLOGY, SLOVAK ACADEMY OF SCIENCES

Inventor： IYER, Janaki Krishnamoorthy ,  KOH, Cho Yeow ,  KINI, R. Manjunatha ,  KAZIMIROVA, Maria ,  ROLLER, Ladislav

IPC: C07K14/81 ,  C07K7/08 ,  C07H21/04 ,  A61K38/57 ,  A61K38/10 ,  A61P7/02

CPC classification number: C07K14/43527 ,  A61K38/00 ,  C07K14/811

Abstract: The present invention provides isolated peptides, variants and fragments thereof that are capable of binding with a high level of specificity to thrombin and inhibiting its activity. There is also provided uses of such peptides in methods of diagnosis and treatment, coating of medical devices and nucleic acids encoding same.

Abstract translation: 本发明提供能够以高水平的凝血酶特异性结合并抑制其活性的分离的肽，变体和片段。 还提供了这样的肽在诊断和治疗方法，医疗装置的涂覆和编码它们的核酸的用途。