公开(公告)号：WO2008005814A3

公开(公告)日：2008-07-31

申请号：PCT/US2007072430

申请日：2007-06-29

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG ,  SOGIN DAVID C ,  SAFER ANTON ,  SMYTH BRENDAN J

Inventor： SOGIN DAVID C ,  SAFER ANTON ,  SMYTH BRENDAN J

IPC: A61B5/00

CPC classification number: C12Q1/485 ,  A61B5/021 ,  A61B5/0285 ,  A61B5/4884 ,  G01N2333/71 ,  G01N2800/321 ,  G01N2800/368

Abstract: A method is provided that allows a subject to be diagnosed as having one of a variety of hypertensive states, including pre-eclampsia, based on the measurement of a plurality of factors including the level of soluble fms-like tyrosine kinase 1 (sFlt-1), an obesity factor and optionally one or more additional factors, which may be physiological parameters or biomarkers. The method can be used to determine hypertensive states associated with pregnancy, or associated with anti-angiogenic drug therapy. The method is thus useful for diagnosing the hypertensive status of pregnant women, as well as patients undergoing anti-angiogenic treatment (e.g., chemotherapy).

Abstract translation: 提供了一种方法，其基于包括可溶性fms样酪氨酸激酶1（sFlt-1）水平在内的多种因子的测量，使受试者被诊断为患有各种高血压状态之一，包括先兆子痫 ），肥胖因子和任选的一种或多种另外的因子，其可以是生理参数或生物标志物。 该方法可用于确定与妊娠相关的高血压状态，或与抗血管生成药物治疗相关。 因此该方法用于诊断孕妇以及进行抗血管生成治疗的患者（例如化疗）的高血压状态。

公开(公告)号：WO2008005814A2

公开(公告)日：2008-01-10

申请号：PCT/US2007/072430

申请日：2007-06-29

Applicant: ABBOTT LABORATORIES ,  ABBOTT GMBH & CO. KG ,  SOGIN, David C. ,  SAFER, Anton ,  SMYTH, Brendan J.

Inventor： SOGIN, David C. ,  SAFER, Anton ,  SMYTH, Brendan J.

IPC: A61B5/103

CPC classification number: C12Q1/485 ,  A61B5/021 ,  A61B5/0285 ,  A61B5/4884 ,  G01N2333/71 ,  G01N2800/321 ,  G01N2800/368

Abstract: A method is provided that allows a subject to be diagnosed as having one of a variety of hypertensive states, including pre-eclampsia, based on the measurement of a plurality of factors including the level of soluble fms-like tyrosine kinase 1 (sFlt-1), an obesity factor and optionally one or more additional factors, which may be physiological parameters or biomarkers. The method can be used to determine hypertensive states associated with pregnancy, or associated with anti-angiogenic drug therapy. The method is thus useful for diagnosing the hypertensive status of pregnant women, as well as patients undergoing anti-angiogenic treatment (e.g., chemotherapy).

Abstract translation: 提供了一种方法，其允许受试者被诊断为具有多种高血压状态之一，包括先兆子痫，基于多种因素的测量，包括可溶性fms样酪氨酸激酶1（sFlt-1 ），肥胖因子和任选的一个或多个另外的因子，其可以是生理参数或生物标志物。 该方法可用于确定与怀孕相关的高血压状态，或与抗血管生成药物治疗相关。 因此，该方法可用于诊断孕妇以及进行抗血管生成治疗（例如化疗）的患者的高血压状态。