公开(公告)号：WO1988005301A1

公开(公告)日：1988-07-28

申请号：PCT/AU1988000017

申请日：1988-01-22

Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY ,  PARISH, Christopher, Richard ,  SNOWDEN, John, McKinnon

Inventor： THE AUSTRALIAN NATIONAL UNIVERSITY

IPC: A61K31/725

CPC classification number: A61K31/715

Abstract: A method of anti-metastatic and/or anti-inflammatory treatment of an animal or human patient comprises administration to the patient of an effective amount of at least one sulphated polysaccharide which blocks or inhibits endoglycosidase, particularly heparanase, activity. Suitable sulphated polysaccharides include heparin and modified heparin, fucoidan, pentosan sulphate, dextran sulphate and carrageenan lambda.

Abstract translation: 动物或人类患者的抗转移和/或抗炎治疗方法包括向患者施用有效量的至少一种阻断或抑制糖苷内切酶，特别是肝素酶活性的硫酸化多糖。 合适的硫酸化多糖包括肝素和改性肝素，岩藻依聚糖，硫酸戊糖聚糖，硫酸葡聚糖和角叉菜胶λ。