公开(公告)号：WO2003014724A1

公开(公告)日：2003-02-20

申请号：PCT/AU2002/001113

申请日：2002-08-05

Applicant: BIOTRON LIMITED ,  PARISH, Christopher, Richard ,  CABALDA-CRANE, Vivian, Mae

Inventor： PARISH, Christopher, Richard ,  CABALDA-CRANE, Vivian, Mae

IPC: G01N30/72

CPC classification number: G01N33/6848 ,  G01N30/7233 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/57488 ,  G01N33/6851 ,  G01N2405/06

Abstract: Provided are novel cancer markers for the diagnosis of cancer in humans and non-human mammalian subjects, specifically a cancer marker comprising a negatively-charged molecule with a mass/charge (m/z) ratio of about 991. The cancer marker of the invention may be used to determine the presence of one or more cancerous cells or tumors in a biological sample by assaying the sample for a reduced level of said cancer marker.

Abstract translation: 本发明提供了用于人和非人哺乳动物受试者中癌症诊断的新型癌症标志物，特别是包含质量/电荷（m / z）比为约991的带负电荷的分子的癌症标志物。本发明的癌症标志物 可用于通过测定样品以降低水平的所述癌症标志物来确定生物样品中一种或多种癌细胞或肿瘤的存在。

公开(公告)号：WO1996033726A1

公开(公告)日：1996-10-31

申请号：PCT/AU1996000238

申请日：1996-04-24

Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY ,  PARISH, Christopher, Richard ,  COWDEN, William, Butler

Inventor： THE AUSTRALIAN NATIONAL UNIVERSITY

IPC: A61K31/70

CPC classification number: A61K31/702 ,  A61K31/722 ,  A61K45/06 ,  C07H3/06 ,  C07H11/00 ,  C08B37/003 ,  A61K31/715 ,  A61K31/40

Abstract: Sulfated oligosaccharides, wherein the oligosaccharide has the general formula (I): R1-(Rx)n-R2, wherein R1 and R2 and each Rx represents a monosaccharide unit, all of which may be the same or different, adjacent monosaccharide units being linked by 1}2, 1}3, 1}4 and/or 1}6 glycosidic bonds and n is an integer of from 1 to 6, and use thereof as anti-angiogenic, anti-metastatic and/or anti-inflammatory agents.

Abstract translation: 硫酸化寡糖，其中寡糖具有通式（I）：R1-（Rx）n-R2，其中R1和R2和每个Rx表示单糖单元，其全部可以相同或不同，相邻的单糖单元连接 通过1} 2,1} 3,1} 4和/或1} 6糖苷键，n是1至6的整数，并且其用作抗血管生成，抗转移和/或抗炎药。

公开(公告)号：WO1990001938A1

公开(公告)日：1990-03-08

申请号：PCT/AU1989000350

申请日：1989-08-18

Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY ,  PARISH, Christopher, Richard ,  COWDEN, William, Butler ,  WILLENBORG, David, Otto

Inventor： THE AUSTRALIAN NATIONAL UNIVERSITY

IPC: A61K31/725

CPC classification number: A61K31/7004 ,  A61K31/70 ,  C07H11/04 ,  C07H13/04

Abstract: A method of anti-inflammatory and/or immunosuppressive treatment of an animal or human patient comprises administration to the patient of an effective amount of at least one phosphosugar or derivative thereof, or a phosphosugar-containing oligosaccharide or polysaccharide or derivative thereof.

Abstract translation: 动物或人类患者的抗炎和/或免疫抑制治疗方法包括向患者施用有效量的至少一种磷脂糖或其衍生物，或含有磷脂糖的寡糖或多糖或其衍生物。

公开(公告)号：WO1988005301A1

公开(公告)日：1988-07-28

申请号：PCT/AU1988000017

申请日：1988-01-22

Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY ,  PARISH, Christopher, Richard ,  SNOWDEN, John, McKinnon

Inventor： THE AUSTRALIAN NATIONAL UNIVERSITY

IPC: A61K31/725

CPC classification number: A61K31/715

Abstract: A method of anti-metastatic and/or anti-inflammatory treatment of an animal or human patient comprises administration to the patient of an effective amount of at least one sulphated polysaccharide which blocks or inhibits endoglycosidase, particularly heparanase, activity. Suitable sulphated polysaccharides include heparin and modified heparin, fucoidan, pentosan sulphate, dextran sulphate and carrageenan lambda.

Abstract translation: 动物或人类患者的抗转移和/或抗炎治疗方法包括向患者施用有效量的至少一种阻断或抑制糖苷内切酶，特别是肝素酶活性的硫酸化多糖。 合适的硫酸化多糖包括肝素和改性肝素，岩藻依聚糖，硫酸戊糖聚糖，硫酸葡聚糖和角叉菜胶λ。

公开(公告)号：WO2006102717A1

公开(公告)日：2006-10-05

申请号：PCT/AU2006/000432

申请日：2006-03-31

Applicant: PARISH, Christopher, Richard ,  DJORDJEVIC, Michael, A. ,  ROLFE, Barry, G. ,  GRESSHOFF, Peter, M.

Inventor： PARISH, Christopher, Richard ,  DJORDJEVIC, Michael, A. ,  ROLFE, Barry, G. ,  GRESSHOFF, Peter, M.

IPC: A61K31/715 ,  A61P1/00 ,  A61P35/00 ,  A61K31/7016 ,  A61P9/10 ,  A61P35/04 ,  A61K31/702 ,  A61P19/02 ,  A61K31/7024 ,  A61P19/08

CPC classification number: A61K31/7016 ,  A61K31/702 ,  A61K31/7024 ,  A61K31/715

Abstract: This invention relates to the use of Nod factors and derivatives thereof for the modulation of blood vessel growth and development as well as compositions for modulating angiogenesis.

Abstract translation: 本发明涉及节点因子及其衍生物用于调节血管生长和发育以及用于调节血管发生的组合物的用途。

公开(公告)号：WO2011109877A1

公开(公告)日：2011-09-15

申请号：PCT/AU2011/000284

申请日：2011-03-11

Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY ,  PARISH, Christopher, Richard ,  SIMEONOVIC, Charmaine ,  FREEMAN, Craig, Geoffrey

Inventor： PARISH, Christopher, Richard ,  SIMEONOVIC, Charmaine ,  FREEMAN, Craig, Geoffrey

IPC: A61K31/727 ,  A61P3/10 ,  A61K31/737 ,  A61P37/00

CPC classification number: A61K31/737 ,  A61K31/727 ,  A61K45/06 ,  A61K47/60 ,  A61K2300/00

Abstract: The present invention relates to a method for inhibiting oxidative damage of islet beta cells in vivo in a subject by administering to the subject a therapeutically effective amount of heparan sulfate capable of protecting islet beta cells from reactive oxygen species or in vitro by exposing isolated islet beta cells, prior to transplantation, to a concentration of heparan sulfate that protects them from reactive oxygen species.

Abstract translation: 本发明涉及一种抑制受试者体内胰岛β细胞氧化损伤的方法，该方法通过向受试者施用能够从活性氧物种保护胰岛β细胞的治疗有效量的硫酸乙酰肝素，或通过暴露分离的胰岛β 细胞在移植前，以硫酸乙酰肝素的浓度保护它们免受活性氧的影响。

公开(公告)号：WO2008046162A1

公开(公告)日：2008-04-24

申请号：PCT/AU2007/001603

申请日：2007-10-22

Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY ,  SIMEONOVIC, Charmaine ,  PARISH, Christopher, Richard ,  ZIOLKOWSKI, Andrew

Inventor： SIMEONOVIC, Charmaine ,  PARISH, Christopher, Richard ,  ZIOLKOWSKI, Andrew

IPC: A61K31/737 ,  A61K31/785 ,  A61K31/706 ,  A61K31/734 ,  A61K31/7125 ,  A61K31/7024 ,  A61K31/445 ,  A61K31/403 ,  A61K31/712 ,  A61K31/185 ,  A61P37/00 ,  A61K31/775 ,  A61K31/255 ,  A61K31/404 ,  A61K31/795 ,  A61K31/223 ,  A61K31/09

CPC classification number: A61K31/09 ,  A61K31/185 ,  A61K31/223 ,  A61K31/255 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/7024 ,  A61K31/706 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/734 ,  A61K31/737 ,  A61K31/775 ,  A61K31/785 ,  A61K31/795

Abstract: This application realtes to a method of inhibiting the degradation of an extracellular matrix associated with islet beta cells, said method comprising contacting said extracellular matrix with an effective amount of a heparanase inhibitor.

Abstract translation: 该应用涉及抑制与胰岛β细胞相关的细胞外基质降解的方法，所述方法包括使所述细胞外基质与有效量的乙酰肝素酶抑制剂接触。

公开(公告)号：WO0208760A8

公开(公告)日：2002-04-18

申请号：PCT/AU0100877

申请日：2001-07-19

Applicant: BIOTRON LTD ,  PARISH CHRISTOPHER RICHARD ,  CABALDA CRANE VIVIAN MAE

Inventor： PARISH CHRISTOPHER RICHARD ,  CABALDA-CRANE VIVIAN MAE

IPC: G01N27/62 ,  G01N27/64 ,  G01N33/483 ,  G01N33/574 ,  G01N30/72 ,  G01N33/50 ,  G01N33/66 ,  G01N33/92 ,  H01J49/40

CPC classification number: G01N33/574 ,  G01N2400/10 ,  G01N2405/00 ,  G01N2405/10

Abstract: The present invention provides a mass spectrometry-based method of identifying a cancer marker in sera and uses of said cancer marker in diagnosing cancer in human and non-human subjects. The invention further provides isolated cancer markers.

Abstract translation: 本发明提供一种鉴定血清中的癌症标志物的质谱法和用于诊断人类和非人类受试者的癌症的所述癌症标志物的用途。 本发明还提供了分离的癌症标志物。

公开(公告)号：WO1990001319A1

公开(公告)日：1990-02-22

申请号：PCT/AU1989000341

申请日：1989-08-09

Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY ,  WILLENBORG, David, Otto ,  COWDEN, William, Butler ,  PARISH, Christopher, Richard

Inventor： THE AUSTRALIAN NATIONAL UNIVERSITY

IPC: A61K31/445

CPC classification number: A61K31/445

Abstract: A method of anti-inflammatory and/or immunosuppressive treatment of an animal or human patient comprises administration to the patient of an effective amount of castanospermine.

Abstract translation: 动物或人类患者的抗炎和/或免疫抑制治疗方法包括向患者施用有效量的睾丸精。

公开(公告)号：WO2005018610A1

公开(公告)日：2005-03-03

申请号：PCT/AU2004/001125

申请日：2004-08-23

Applicant: LIPOTEK PTY LTD ,  ALTIN, Joseph ,  PARISH, Christopher, Richard

Inventor： ALTIN, Joseph ,  PARISH, Christopher, Richard

IPC: A61K9/127

CPC classification number: A61K39/395 ,  A61K9/127 ,  A61K31/4172 ,  A61K38/217 ,  A61K39/00 ,  A61K39/0002 ,  A61K39/0011 ,  A61K39/02 ,  A61K39/04 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/55516 ,  A61K2039/55522 ,  A61K2039/55527 ,  A61K2039/55533 ,  A61K2039/55538 ,  A61K2039/55555 ,  A61K2039/55572

Abstract: The invention provides a composition for modulating immunity by the in vivo targeting of an antigen to dendritic cells. The composition comprises: a preparation of antigen-containing membrane vesicles or antigen-containing liposomes which have on their surfaces a plurality of metal chelating groups; and, a ligand for a receptor on the dendritic cells, the ligand being linked to a metal chelating group via a metal affinity tag on the ligand. The composition further includes an immunomodulatory factor. A process for preparing the composition is also provided. The invention further provides a method of modulating an immune disorder, and methods of treating tumours and infections.

Abstract translation: 本发明提供了一种用于通过体内靶向抗原至树突状细胞来调节免疫的组合物。 该组合物包括：含有抗原的膜囊泡或含抗原的脂质体的制备物，其表面上具有多个金属螯合基团; 和在树突状细胞上的受体的配体，该配体通过配体上的金属亲和标签与金属螯合基团连接。 组合物还包括免疫调节因子。 还提供了制备该组合物的方法。 本发明还提供了调节免疫疾病的方法，以及治疗肿瘤和感染的方法。