公开(公告)号：WO2021148171A1

公开(公告)日：2021-07-29

申请号：PCT/EP2020/083736

申请日：2020-11-27

Applicant: SPECTRUM MEDICAL LTD

Inventor： TURNER, Stephen

IPC: A61M1/36 ,  A61M1/3644 ,  A61M1/3666 ,  A61M2205/3334

Abstract: A control system for a perfusion system (1), the control system being configured to control a plurality of blood flow rates in the perfusion system during a weaning phase. The perfusion system comprises: a first blood line (26) in which blood is permitted to flow at a first flow rate; a second blood line (34) in which blood is permitted to flow at a second flow rate; an arterial blood line (22) in which blood is permitted to flow at an arterial flow rate; and an arterial pump (20) configured to circulate blood at the arterial flow rate in the arterial blood line. The control system comprises a controller configured to determine the first flow rate and the second flow rate and to process the first and second flow rates to determine a desired arterial flow rate. The controller is configured to operate in a first mode in which the controller modulates operation of the arterial pump (20) to adjust the arterial flow rate so that the arterial flow rate matches the desired arterial flow rate.

公开(公告)号：WO2017085464A1

公开(公告)日：2017-05-26

申请号：PCT/GB2016/053529

申请日：2016-11-10

Applicant: SPECTRUM MEDICAL LTD.

Inventor： TURNER, Stephen

IPC: A61M1/36

CPC classification number: A61M1/1086 ,  A61M1/101 ,  A61M1/1039 ,  A61M1/3639 ,  A61M1/3663 ,  A61M1/3666 ,  A61M2205/3334 ,  A61M2230/30

Abstract: A control system in a blood line (12) of a cardiopulmonary bypass perfusion system (1) comprises a flow sensor (26) to determine a flow value indicative of the flow rate, a controller configured to process the flow value, and an adjustable restriction (28) responsive to the controller, to reduce the flow rate in the venous blood line (12) to maintain a flow rate to the venous blood reservoir that does not exceed a restriction threshold. As the adjustable restriction (28) is responsive to the flow sensor (26), this provides a closed loop control mechanism that avoids restricting the blood line (12) of the perfusion system (1) more than intended.

Abstract translation: 心肺旁路灌注系统（1）的血液管线（12）中的控制系统包括：流量传感器（26），其确定指示流量的流量值;控制器，其被配置为处理 所述流量值和响应于所述控制器的可调节限制器（28），以降低所述静脉血液管线（12）中的流速，以维持流向所述静脉血液贮存器的流速不超过限制阈值。 由于可调节限制器28响应于流量传感器26，所以这提供了闭环控制机构，该机构避免了比预期更多地限制灌注系统1的血液管线12。

公开(公告)号：WO2016075453A1

公开(公告)日：2016-05-19

申请号：PCT/GB2015/053404

申请日：2015-11-10

Applicant: SPECTRUM MEDICAL LTD.

Inventor： TURNER, Stephen

IPC: A61M5/168 ,  A61M1/36 ,  A61M5/145

CPC classification number: A61M1/3664 ,  A61M5/1452 ,  A61M5/16827 ,  A61M5/16854 ,  A61M5/172 ,  A61M2205/276 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/50

Abstract: Cardioplegic agent delivery system A cardioplegic agent delivery system comprises a syringe pump for providing cardioplegic agent into a carrier fluid of a perfusion system, a flow sensor for sensing a flow of the carrier fluid,andan interlock responsive to the flow sensor. The interlock preventsoperation of the syringe pump in the absence of carrier fluid flow sensed by the flow sensor. This provides increased safety in a cardioplegic agent delivery system.

Abstract translation: 心脏停搏剂递送系统一种心脏停搏剂递送系统包括用于将心脏停跳药剂提供到灌注系统的载体流体的注射泵，用于感测载体流体流的流量传感器，以及响应于流量传感器的互锁。 在没有由流量传感器感测到的载体流体流动的情况下，联锁防止注射器泵的运动。 这提供了在心脏停药剂递送系统中增加的安全性。

公开(公告)号：WO2020074856A1

公开(公告)日：2020-04-16

申请号：PCT/GB2019/052770

申请日：2019-10-02

Applicant: SPECTRUM MEDICAL LTD.

Inventor： TAMARI, Jeremy

IPC: A61M39/02 ,  A61M1/36

Abstract: The invention relates to a vascular access device (10) for implantation onto a vessel wall, the access device comprising an tubular structure (12) to provide an access passage into the vessel via a hole in a vessel wall, a connector arrangement (20; 21) for attaching the tubular structure at said hole in the vessel wall, and a membrane structure (16A; 16B) sufficiently flexible to be collapsed for insertion through said hole and to be expanded to lie at least partially against an inner vessel surface thereby to surround the hole. The membrane structure comprises a membrane aperture (18) to provide a passage from inside the vessel into the tubular structure. The vascular access device further comprises a closing mechanism capable of closing the membrane aperture while the membrane structure is expanded against said inner vessel surface.There is also provided a method of implanting a vascular access device.

公开(公告)号：WO2019016542A1

公开(公告)日：2019-01-24

申请号：PCT/GB2018/052027

申请日：2018-07-17

Applicant: SPECTRUM MEDICAL LTD.

Inventor： TURNER, Stephen ,  GARBUTT, Benjamin David

IPC: A61M1/36

Abstract: A heater-cooler apparatus of an extracorporeal perfusion system comprises at least one fluid circuit (102, 104) providing a supply of a heat transfer fluid to the perfusion system, a cold storage unit (266), and a refrigeration unit (250) for charging the cold storage unit (266). The cold storage unit (266) comprises a chamber (312) containing a liquid that freezes at a temperature above that to which the heat transfer fluid is cooled by the refrigeration unit (250), and a passage through which the heat transfer fluid is conveyed, the passage extending through the chamber (312). This allows a more effective cold storage unit to be provided.

公开(公告)号：WO2016113545A1

公开(公告)日：2016-07-21

申请号：PCT/GB2016/050044

申请日：2016-01-08

Applicant: SPECTRUM MEDICAL LTD.

Inventor： TURNER, Stephen

IPC: A61M39/28 ,  F16K7/06

CPC classification number: A61M39/287 ,  A61M39/28 ,  A61M39/285 ,  A61M39/286 ,  F04B43/12 ,  F16K7/04 ,  F16K35/10

Abstract: A clamp arrangement for retaining a flexible tube (18)during operation of a roller pump (10) for pumping fluid, the clamp arrangement comprising a pair of rotatable bobbins (24A, 24B, 26A, 26B) mounted adjacent to each other. Each bobbin (24A, 24B, 26A,26B) has a tapered groove (30), formed partially around a cylindrical surface of the bobbin (24A, 24B, 26A, 26B),and counter rotation of the bobbins (24A, 24B, 26A, 26B) clamps the tube 18 between the bobbins (24A, 24B, 26A, 26B) in the tapered grooves (30). The clamp arrangement allows tubes of different shapes and diameters to be securely held without overly deforming the tube.

Abstract translation: 一种用于在用于泵送流体的辊式泵（10）的操作期间保持柔性管（18）的夹紧装置，所述夹具装置包括彼此相邻安装的一对可旋转的筒管（24A，24B，26A，26B）。 每个线轴（24A，24B，26A，26B）具有部分地围绕线轴（24A，24B，26A，26B）的圆柱形表面形成的锥形槽（30），并且线轴（24A，24B，26A） ，26B）将管18夹在锥形槽（30）中的筒管（24A，24B，26A，26B）之间。 夹具装置允许不同形状和直径的管被牢固地保持而不会使管变形过大。

公开(公告)号：WO2016087859A1

公开(公告)日：2016-06-09

申请号：PCT/GB2015/053694

申请日：2015-12-03

Applicant: SPECTRUM MEDICAL LTD.

Inventor： TURNER, Stephen

IPC: A61M1/16 ,  A61M1/36

CPC classification number: A61M1/1698 ,  A61M1/32 ,  A61M1/3632 ,  A61M1/3666 ,  A61M1/3667 ,  A61M16/101 ,  A61M16/22 ,  A61M2205/3334 ,  A61M2205/3341

Abstract: An oxygenation system for a ventilation system comprises an inlet for receiving oxygenation gas at an oxygenation gas flow rate into an oxygenator, and an exhaust gas remover to remove exhaust gas at an exhaust gas flow rate from the oxygenator, and one or more flow controllers for controlling the exhaust gas flow rate relative to the oxygenation gas flow rate. This allows the amount of total gas entering the oxygenator and the amount of total gas removed from the oxygenator to be controlled with greater accuracy.

Abstract translation: 用于通气系统的氧合系统包括用于接收以氧合气流量进入氧合器的氧化气体的入口，以及排气净化器，以从所述氧合器排出的废气流量除去废气;以及一个或多个流量控制器，用于 控制相对于氧合气体流量的废气流量。 这允许以更高的精度控制进入氧合器的总气体量和从氧合器去除的总气体的量。

公开(公告)号：WO2012066280A3

公开(公告)日：2012-08-02

申请号：PCT/GB2011001602

申请日：2011-11-15

Applicant: SPECTRUM MEDICAL LTD ,  HART ANDREW IAN

Inventor： HART ANDREW IAN

IPC: A61B5/145 ,  A61M1/16

CPC classification number: A61B5/14542 ,  A61M1/1698

Abstract: A blood analysis apparatus is provided for use in a system in which blood from a patient is provided to an oxygenator (40) and in which blood from the oxygenator (40) is provided back to the patient. The apparatus comprises a first group of sensors (6, 7) for directly measuring a corresponding first group of properties of the blood provided to or from the oxygenator (40). The apparatus comprises a second group of sensors (1, 2, 3, 4) for directly measuring a corresponding second group of properties of a gas provided to or from the oxygenator (40). The apparatus comprises a processor (60) for determining a value for the partial pressure of oxygen in the blood and/or a value for the partial pressure of carbon dioxide in the blood in dependence upon the first group of directly measured properties and the second group of directly measured properties.

Abstract translation: 提供一种血液分析装置，用于将来自患者的血液提供给氧合器（40）并将来自氧合器（40）的血液提供回患者的系统中。 该装置包括第一组传感器（6,7），用于直接测量提供给氧合器（40）或从氧合器（40）提供的血液的对应第一组性质。 该设备包括用于直接测量提供给氧合器（40）或从氧合器（40）提供的气体的对应第二组性质的第二组传感器（1,2,3,4）。 该装置包括处理器（60），用于根据第一组直接测量的特性确定血液中的氧气分压值和/或血液中二氧化碳分压值，第二组 直接测量的属性。

公开(公告)号：WO2020002872A1

公开(公告)日：2020-01-02

申请号：PCT/GB2019/051586

申请日：2019-06-07

Applicant: SPECTRUM MEDICAL LTD

Inventor： TAMARI, Jeremy

IPC: A61F2/06 ,  A61M1/10 ,  A61M1/36

Abstract: A vascular access tube (2) for a fluid subject to a driving pressure comprises a wall (4) defining a main lumen. A portion of the wall comprises an access port (10) for an object (14) to be introduced through the wall. The access port comprises a biasing structure (12) which provides a self-closing behaviour that is sufficiently strong to remain fluid-tight when exposed to a driving pressure of up to 50 mmHg. The access port is therefore sufficiently fluid-tight to contain pressurised fluid flowing through the vascular access tube.

公开(公告)号：WO2019224533A1

公开(公告)日：2019-11-28

申请号：PCT/GB2019/051403

申请日：2019-05-21

Applicant: SPECTRUM MEDICAL LTD

Inventor： BOWERS, Scott

IPC: A61M1/16

Abstract: A blood gas management device comprises a blood passage having a gas-blood interface with a plurality of gas passages, and is arranged to direct a flow of supply gas from the gas inlets through the gas passages to the gas outlets, and to allow a flow of blood in a blood flow path through the blood passage to thereby permit an exchange of blood gas with the supply gas via the interface. The blood gas management device comprises a supply gas distribution arrangement allowing the supply gas to be provided from different directions relative to the blood flow path. This provides an improved gas- transfer gradient at different locations along the gas passage.