公开(公告)号：WO2018064499A1

公开(公告)日：2018-04-05

申请号：PCT/US2017/054339

申请日：2017-09-29

Applicant: SPYRYX BIOSCIENCES, INC.

Inventor： CROWDER, Timothy, Morgan ,  CHRISTENSEN, Dale, J. ,  TAYLOR, John, Clayton

IPC: A61K38/00 ,  A61K38/08 ,  A61K38/17 ,  C07K7/00 ,  C07K14/435

Abstract: The present invention relates to the ability of specialized non-naturally occurring peptides to bind to sodium channels and inhibit activation of the sodium channels. The invention further relates to methods for regulating of sodium absorption and fluid volume and treating disorders responsive to modulating sodium absorption by modulating the binding of specialized non-naturally occurring peptides to sodium channels.

Abstract translation: 本发明涉及特定的非天然存在的肽结合钠通道并抑制钠通道活化的能力。 本发明进一步涉及调节钠吸收和液体体积并通过调节特定的非天然存在的肽与钠通道的结合来治疗对调节钠吸收有反应的病症的方法。

公开(公告)号：WO2019067887A1

公开(公告)日：2019-04-04

申请号：PCT/US2018/053405

申请日：2018-09-28

Applicant: SPYRYX BIOSCIENCES, INC.

Inventor： SCOTT, David Wayne ,  SESMA, Juliana I. ,  WALKER, Paul Matthew

IPC: A61K38/00 ,  A61K38/04 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16

CPC classification number: C07K7/06 ,  A61K38/00

Abstract: The disclosure relates to epithelial sodium channel (ENaC) inhibitor compounds and peptides and uses thereof, e.g. , in the treatment of a disorder related to sodium channel, such as, for example, cystic fibrosis, idiopathic pulmonary fibrosis, or chronic obstructive pulmonary disease.

公开(公告)号：WO2016057795A1

公开(公告)日：2016-04-14

申请号：PCT/US2015/054693

申请日：2015-10-08

Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  SPYRYX BIOSCIENCES, INC.

Inventor： TARRAN, Robert ,  CHRISTENSEN, Dale J.

IPC: A61K38/04 ,  A61K38/16 ,  A61P1/00 ,  A61P11/06 ,  A61P11/08 ,  A61P11/12 ,  C07K14/435

CPC classification number: C07K7/08 ,  A61K9/0073 ,  A61K38/00 ,  C07K5/06026 ,  C07K7/06 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/10

Abstract: The present invention relates to the ability of specialized non-naturally occurring peptides to bind to sodium channels and inhibit activation of the sodium channels. The invention further relates to methods for regulating of sodium absorption and fluid volume and treating disorders responsive to modulating sodium absorption by modulating the binding of specialized non-naturally occurring peptides to sodium channels.

Abstract translation: 本发明涉及专门的非天然存在的肽结合钠通道并抑制钠通道活化的能力。 本发明还涉及通过调节专门的非天然存在的肽与钠通道的结合来调节钠吸收和流体体积以及治疗响应于调节钠吸收的病症的方法。