公开(公告)号：WO2008018089A1

公开(公告)日：2008-02-14

申请号：PCT/IN2007/000326

申请日：2007-08-02

Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH ,  PRATAP, Ram ,  SINGH, Himanshu ,  VERMA, Alok, Kumar ,  SINGH, Amar, Bahadur ,  TIWARI, Priti ,  SRIVASTAVA, Mukesh ,  SRIVASTAVA, Arvind, Kumar ,  DWIVEDI, Anil, Kumar ,  SINGH, Satyawan ,  SRIVASTAVA, Pratima ,  SINGH, Shio, Kumar ,  NATH, Chandishwar ,  RAGHUBIR, Ram

Inventor： PRATAP, Ram ,  SINGH, Himanshu ,  VERMA, Alok, Kumar ,  SINGH, Amar, Bahadur ,  TIWARI, Priti ,  SRIVASTAVA, Mukesh ,  SRIVASTAVA, Arvind, Kumar ,  DWIVEDI, Anil, Kumar ,  SINGH, Satyawan ,  SRIVASTAVA, Pratima ,  SINGH, Shio, Kumar ,  NATH, Chandishwar ,  RAGHUBIR, Ram

IPC: C07D311/30 ,  A61K31/352 ,  A61P3/10

CPC classification number: C07D311/30

Abstract: The present invention provides an optically active compound of general formula (I) and salts thereof: wherein R' is selected from a group consisting of t-butyl amine, n-butylamine, iso- butylamine, iso-propyl amine, 4-phenyl-piperazine-1-ylamine, 4-(2-methoxyphenyl)- piperazin-1-ylamine, and 3, 4-dimethoxy phenethyl amine; wherein R 1 , R 2 and R 3 are selected from the group consisting of hydrogen, methyl or iso pentenyl; R 4 , R 5 and R 6 are selected from the group consisting of OH, O-alkyl, O-benzyl, O-substituted phenyl or combination thereof.

Abstract translation: 本发明提供通式（I）的光学活性化合物及其盐：其中R'选自叔丁胺，正丁胺，异丁胺，异丙基胺，4-苯基 - 哌嗪-1-基胺，4-（2-甲氧基苯基） - 哌嗪-1-基胺和3,4-二甲氧基苯乙胺; 其中R 1，R 2和R 3选自氢，甲基或异戊烯基; R 4，R 5和R 6选自OH，O-烷基，O-苄基，O-取代的苯基 或其组合。

公开(公告)号：WO2008018089A9

公开(公告)日：2014-12-31

申请号：PCT/IN2007000326

申请日：2007-08-02

Applicant: COUNCIL SCIENT IND RES ,  PRATAP RAM ,  SINGH HIMANSHU ,  VERMA ALOK KUMAR ,  SINGH AMAR BAHADUR ,  TIWARI PRITI ,  SRIVASTAVA MUKESH ,  SRIVASTAVA ARVIND KUMAR ,  DWIVEDI ANIL KUMAR ,  SINGH SATYAWAN ,  SRIVASTAVA PRATIMA ,  SINGH SHIO KUMAR ,  NATH CHANDISHWAR ,  RAGHUBIR RAM

Inventor： PRATAP RAM ,  SINGH HIMANSHU ,  VERMA ALOK KUMAR ,  SINGH AMAR BAHADUR ,  TIWARI PRITI ,  SRIVASTAVA MUKESH ,  SRIVASTAVA ARVIND KUMAR ,  DWIVEDI ANIL KUMAR ,  SINGH SATYAWAN ,  SRIVASTAVA PRATIMA ,  SINGH SHIO KUMAR ,  NATH CHANDISHWAR ,  RAGHUBIR RAM

IPC: C07D311/30 ,  A61K31/352 ,  A61P3/10

CPC classification number: C07D311/30

Abstract: The present invention provides an optically active compound of general formula (I) and salts thereof: wherein R' is selected from a group consisting of t-butyl amine, n-butylamine, iso- butylamine, iso-propyl amine, 4-phenyl-piperazine-1-ylamine, 4-(2-methoxyphenyl)- piperazin-1-ylamine, and 3, 4-dimethoxy phenethyl amine; wherein R1, R2 and R3 are selected from the group consisting of hydrogen, methyl or iso pentenyl; R4, R5 and R6 are selected from the group consisting of OH, O-alkyl, O-benzyl, O-substituted phenyl or combination thereof.

Abstract translation: 本发明提供通式（I）的光学活性化合物及其盐：其中R'选自叔丁胺，正丁胺，异丁胺，异丙基胺，4-苯基 - 哌嗪-1-基胺，4-（2-甲氧基苯基） - 哌嗪-1-基胺和3,4-二甲氧基苯乙胺; 其中R1，R2和R3选自氢，甲基或异戊烯基; R 4，R 5和R 6选自OH，O-烷基，O-苄基，O-取代的苯基或其组合。