公开(公告)号：WO2008018089A9

公开(公告)日：2014-12-31

申请号：PCT/IN2007000326

申请日：2007-08-02

Applicant: COUNCIL SCIENT IND RES ,  PRATAP RAM ,  SINGH HIMANSHU ,  VERMA ALOK KUMAR ,  SINGH AMAR BAHADUR ,  TIWARI PRITI ,  SRIVASTAVA MUKESH ,  SRIVASTAVA ARVIND KUMAR ,  DWIVEDI ANIL KUMAR ,  SINGH SATYAWAN ,  SRIVASTAVA PRATIMA ,  SINGH SHIO KUMAR ,  NATH CHANDISHWAR ,  RAGHUBIR RAM

Inventor： PRATAP RAM ,  SINGH HIMANSHU ,  VERMA ALOK KUMAR ,  SINGH AMAR BAHADUR ,  TIWARI PRITI ,  SRIVASTAVA MUKESH ,  SRIVASTAVA ARVIND KUMAR ,  DWIVEDI ANIL KUMAR ,  SINGH SATYAWAN ,  SRIVASTAVA PRATIMA ,  SINGH SHIO KUMAR ,  NATH CHANDISHWAR ,  RAGHUBIR RAM

IPC: C07D311/30 ,  A61K31/352 ,  A61P3/10

CPC classification number: C07D311/30

Abstract: The present invention provides an optically active compound of general formula (I) and salts thereof: wherein R' is selected from a group consisting of t-butyl amine, n-butylamine, iso- butylamine, iso-propyl amine, 4-phenyl-piperazine-1-ylamine, 4-(2-methoxyphenyl)- piperazin-1-ylamine, and 3, 4-dimethoxy phenethyl amine; wherein R1, R2 and R3 are selected from the group consisting of hydrogen, methyl or iso pentenyl; R4, R5 and R6 are selected from the group consisting of OH, O-alkyl, O-benzyl, O-substituted phenyl or combination thereof.

Abstract translation: 本发明提供通式（I）的光学活性化合物及其盐：其中R'选自叔丁胺，正丁胺，异丁胺，异丙基胺，4-苯基 - 哌嗪-1-基胺，4-（2-甲氧基苯基） - 哌嗪-1-基胺和3,4-二甲氧基苯乙胺; 其中R1，R2和R3选自氢，甲基或异戊烯基; R 4，R 5和R 6选自OH，O-烷基，O-苄基，O-取代的苯基或其组合。

公开(公告)号：WO2007031830A2

公开(公告)日：2007-03-22

申请号：PCT/IB2006/002462

申请日：2006-09-07

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH ,  LAKSHMI, Vijai ,  SAXENA, Ajet ,  KUMAR, Rajesh ,  PAL, Raghwendra ,  SINGH, Satyawan ,  SRIVASTAVA, Arvind, Kumar ,  TIWARI, Preeti ,  RAINA, Deepak ,  RASTOGI, Anil, Kumar ,  SRIVASTAVA, Sudhir ,  SRIVASTAVA, Mahendra, Nath ,  CHANDRA, Ramesh ,  PURI, Anju ,  RAGHUBIR, Ram ,  GUPTA, Poonam ,  TADIGOPPULA, Narender ,  TRIPATHI, Brijendra, Kumar

Inventor： LAKSHMI, Vijai ,  SAXENA, Ajet ,  KUMAR, Rajesh ,  PAL, Raghwendra ,  SINGH, Satyawan ,  SRIVASTAVA, Arvind, Kumar ,  TIWARI, Preeti ,  RAINA, Deepak ,  RASTOGI, Anil, Kumar ,  SRIVASTAVA, Sudhir ,  SRIVASTAVA, Mahendra, Nath ,  CHANDRA, Ramesh ,  PURI, Anju ,  RAGHUBIR, Ram ,  GUPTA, Poonam ,  TADIGOPPULA, Narender ,  TRIPATHI, Brijendra, Kumar

CPC classification number: A61K36/58 ,  C07D493/18

Abstract: The present invention discloses a bioactive fraction obtained from Xylocarpus useful for the treatment of diabetes and dyslipidemia. Further, it relates to a pharmaceutical composition useful as antidiabetic and antidyslipidemic agent. The current embodiment also discusses to a method of treating diabetes and dyslipidemia in a subject. Further, the present invention relates to the novel isomeric xyloccensins and use thereof.

Abstract translation: 本发明公开了可用于治疗糖尿病和血脂异常的从Xylocarpus得到的生物活性成分。 此外，其涉及可用作抗糖尿病和抗脂肪代谢剂的药物组合物。 目前的实施方案还讨论了在受试者中治疗糖尿病和血脂异常的方法。 此外，本发明涉及新型异构体的木糖蛋白及其用途。

公开(公告)号：WO2007031830A3

公开(公告)日：2007-07-12

申请号：PCT/IB2006002462

申请日：2006-09-07

Applicant: COUNCIL SCIENT IND RES ,  LAKSHMI VIJAI ,  SAXENA AJET ,  KUMAR RAJESH ,  PAL RAGHWENDRA ,  SINGH SATYAWAN ,  SRIVASTAVA ARVIND KUMAR ,  TIWARI PREETI ,  RAINA DEEPAK ,  RASTOGI ANIL KUMAR ,  SRIVASTAVA SUDHIR ,  SRIVASTAVA MAHENDRA NATH ,  CHANDRA RAMESH ,  PURI ANJU ,  RAGHUBIR RAM ,  GUPTA POONAM ,  TADIGOPPULA NARENDER ,  TRIPATHI BRIJENDRA KUMAR

Inventor： LAKSHMI VIJAI ,  SAXENA AJET ,  KUMAR RAJESH ,  PAL RAGHWENDRA ,  SINGH SATYAWAN ,  SRIVASTAVA ARVIND KUMAR ,  TIWARI PREETI ,  RAINA DEEPAK ,  RASTOGI ANIL KUMAR ,  SRIVASTAVA SUDHIR ,  SRIVASTAVA MAHENDRA NATH ,  CHANDRA RAMESH ,  PURI ANJU ,  RAGHUBIR RAM ,  GUPTA POONAM ,  TADIGOPPULA NARENDER ,  TRIPATHI BRIJENDRA KUMAR

IPC: A61K36/58 ,  A61P3/06 ,  A61P3/10

CPC classification number: A61K36/58 ,  C07D493/18

Abstract: The present invention discloses a bioactive fraction obtained from Xylocarpus useful for the treatment of diabetes and dyslipidemia. Further, it relates to a pharmaceutical composition useful as antidiabetic and antidyslipidemic agent. The current embodiment also discusses to a method of treating diabetes and dyslipidemia in a subject. Further, the present invention relates to the novel isomeric xyloccensins and use thereof.

Abstract translation: 本发明公开了可用于治疗糖尿病和血脂异常的从Xylocarpus得到的生物活性成分。 此外，其涉及可用作抗糖尿病和抗脂肪代谢剂的药物组合物。 目前的实施方案还讨论了在受试者中治疗糖尿病和血脂异常的方法。 此外，本发明涉及新型异构体的木糖蛋白及其用途。

公开(公告)号：WO2008018089A1

公开(公告)日：2008-02-14

申请号：PCT/IN2007/000326

申请日：2007-08-02

Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH ,  PRATAP, Ram ,  SINGH, Himanshu ,  VERMA, Alok, Kumar ,  SINGH, Amar, Bahadur ,  TIWARI, Priti ,  SRIVASTAVA, Mukesh ,  SRIVASTAVA, Arvind, Kumar ,  DWIVEDI, Anil, Kumar ,  SINGH, Satyawan ,  SRIVASTAVA, Pratima ,  SINGH, Shio, Kumar ,  NATH, Chandishwar ,  RAGHUBIR, Ram

Inventor： PRATAP, Ram ,  SINGH, Himanshu ,  VERMA, Alok, Kumar ,  SINGH, Amar, Bahadur ,  TIWARI, Priti ,  SRIVASTAVA, Mukesh ,  SRIVASTAVA, Arvind, Kumar ,  DWIVEDI, Anil, Kumar ,  SINGH, Satyawan ,  SRIVASTAVA, Pratima ,  SINGH, Shio, Kumar ,  NATH, Chandishwar ,  RAGHUBIR, Ram

IPC: C07D311/30 ,  A61K31/352 ,  A61P3/10

CPC classification number: C07D311/30

Abstract: The present invention provides an optically active compound of general formula (I) and salts thereof: wherein R' is selected from a group consisting of t-butyl amine, n-butylamine, iso- butylamine, iso-propyl amine, 4-phenyl-piperazine-1-ylamine, 4-(2-methoxyphenyl)- piperazin-1-ylamine, and 3, 4-dimethoxy phenethyl amine; wherein R 1 , R 2 and R 3 are selected from the group consisting of hydrogen, methyl or iso pentenyl; R 4 , R 5 and R 6 are selected from the group consisting of OH, O-alkyl, O-benzyl, O-substituted phenyl or combination thereof.

Abstract translation: 本发明提供通式（I）的光学活性化合物及其盐：其中R'选自叔丁胺，正丁胺，异丁胺，异丙基胺，4-苯基 - 哌嗪-1-基胺，4-（2-甲氧基苯基） - 哌嗪-1-基胺和3,4-二甲氧基苯乙胺; 其中R 1，R 2和R 3选自氢，甲基或异戊烯基; R 4，R 5和R 6选自OH，O-烷基，O-苄基，O-取代的苯基 或其组合。

公开(公告)号：WO2006040621A1

公开(公告)日：2006-04-20

申请号：PCT/IB2005/001069

申请日：2005-04-13

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH ,  PRATAP, Ram ,  SATYANARAYANA, Mavurapu ,  NATH, Chandeshwar ,  RAGHUBIR, Ram ,  PURI, Anju ,  CHANDER, Ramesh ,  TIWARI, Priti ,  TRIPATHI, Brajendra, Kumar ,  SRIVASTAVA, Arvind, Kumar

Inventor： PRATAP, Ram ,  SATYANARAYANA, Mavurapu ,  NATH, Chandeshwar ,  RAGHUBIR, Ram ,  PURI, Anju ,  CHANDER, Ramesh ,  TIWARI, Priti ,  TRIPATHI, Brajendra, Kumar ,  SRIVASTAVA, Arvind, Kumar

IPC: C07D311/30

CPC classification number: C07D417/12 ,  C07D311/30

Abstract: The present invention provides novel substituted flavone derivatives which exhibit anti­ hyperglycemic and antidyslipedemic activity. The invention also provides a method for controlling type ii diabetes and associated hyperlipidemic conditions in a mammal by administering compound of the present invention and compositions containing these derivatives.

Abstract translation: 本发明提供了具有抗高血糖和抗血脂活性的新型取代黄酮衍生物。 本发明还提供了通过施用本发明的化合物和含有这些衍生物的组合物来控制哺乳动物中II型糖尿病和相关高脂血症的方法。