公开(公告)号：WO2022003152A2

公开(公告)日：2022-01-06

申请号：PCT/EP2021/068315

申请日：2021-07-02

申请人： AARHUS UNIVERSITET ,  REGION MIDTJYLLAND ,  STIPE THERAPEUTICS APS

发明人： HANSEN, Aida Solhøj ,  DELEURAN, Bent Winding ,  JAKOBSEN, Martin Roelsgaard ,  KRAPP, Christian

IPC分类号： C12N5/0783 ,  A61K31/7084 ,  A61K35/17 ,  C12N2501/51 ,  C12N2501/515 ,  C12N5/0636

摘要： This present invention describes extracellular vesicles derived from activated T cells can prime macrophages for enhanced pro-inflammatory response towards stimulation with STING agonists. Further, a direct anti-tumoral effect of extracellular vesicles derived from activated T cells prior to intratumorally injection of cGAMP is demonstrated.