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    ENZYMATIC SYNTHESIS OF OPTICALLY ACTIVE HYDROXAMIC ACIDS AND THEIR CONVERSION INTO OPTICALLY ACTIVE PRIMARY AMINES BY LOSSEN TRANSPOSITION
    7.
    发明申请
    ENZYMATIC SYNTHESIS OF OPTICALLY ACTIVE HYDROXAMIC ACIDS AND THEIR CONVERSION INTO OPTICALLY ACTIVE PRIMARY AMINES BY LOSSEN TRANSPOSITION 审中-公开
    光学活性的异羟肟的酶法合成及其实现以光学活性胺通过伯洛森-TRANSFER

    公开(公告)号：WO1997044480A1

    公开(公告)日：1997-11-27

    申请号：PCT/EP1997002413

    申请日：1997-05-12

    Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ,  HIRRLINGER, Beate ,  STOLZ, Andreas ,  KNACKMUSS, Hans-Joachim

    Inventor： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

    IPC: C12P41/00

    CPC classification number: C12P41/006 ,  C12P13/02

    Abstract: The description relates to a process for producing optically active hydroxamic acids of the general formula (I) in which R , R and R are different and represent a cyclic or linear, aliphatic or aromatic, substituted or unsubstituted hydrocarbon radical which may contain hetero-atoms, characterised in that a racemate of chiral amides, carboxylic acid esters or caboxylic acids of the general formula (II) in which R , R and R are defined as above and X is -NH2, -OR or -OH, R being any organic radical, is reacted with hydroxyl amine NH2OH in the presence of an acyl transferase and the optically active hydroxamic acid (I) thus produced is separated from the unreacted enantiomer of the general formula (II). The optically active hydroxamic acid thus obtained can be converted to the corresponding optically primary amines by Lossen transposition.

    Abstract translation: 公开了一种用于生产式（I）通式的旋光异羟肟酸的方法，其中R <1>，R <2>和R <3>是不同的和环状或直链脂族或芳族的，取代或未取代的烃基，其 任选杂原子可以包含，站，其特征在于，（II），其中R <1>，R <2>和R <3>如上文所定义的手性酰胺，羧酸酯或通式羧酸的外消旋物 和X代表-NH 2，-OR或-OH，R是任何有机残基，与羟胺NH 2 OH中的酰基转移酶的存在下反应，然后将光学活性的异羟肟酸形成（i）从通式的未转化的对映异构体（II）被分离 ， 将这样得到的光学活性的异羟肟酸可通过洛森重排反应进行反应，以相应的旋光的伯胺。

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