公开(公告)号：WO2015006720A1

公开(公告)日：2015-01-15

申请号：PCT/US2014/046398

申请日：2014-07-11

Applicant: WISYS TECHNOLOGY FOUNDATION ,  WU, Tsunghsueh ,  CORNETT, Charles

Inventor： WU, Tsunghsueh ,  CORNETT, Charles

IPC: G01N31/22 ,  G01N21/77

CPC classification number: G01N33/94 ,  G01N31/22 ,  G01N33/946 ,  G01N33/948 ,  G01N33/9486 ,  Y10T436/141111 ,  Y10T436/142222 ,  Y10T436/145555 ,  Y10T436/147777 ,  Y10T436/173845

Abstract: A colorimetric assay to detect certain compounds and a kit therefore are provided.

Abstract translation: 因此提供了检测某些化合物和试剂盒的比色测定法。

公开(公告)号：WO2014125383A2

公开(公告)日：2014-08-21

申请号：PCT/IB2014/000930

申请日：2014-02-11

Applicant: THE AMERICAN UNIVERSITY OF CAIRO

Inventor： AZZAZY, Hassan ,  SHAHAT, Ahmed ,  HASSAN, M.A., Hassan

IPC: G01N21/25

CPC classification number: G01N21/78 ,  B01D2253/204 ,  B01J31/1691 ,  G01N33/1813 ,  G01N33/20 ,  Y10T436/16 ,  Y10T436/173845 ,  Y10T436/19

Abstract: Novel Zr-based metal-organic framework (MOF) chemosensors useful for detection, recognition, removal, and separation of heavy metals are provided. Also provided are methods for preparation of the chemosensors and processes for detection, recognition, removal, and separation of heavy metals using the chemosensors.

Abstract translation: 提供了用于重金属检测，识别，去除和分离的新型Zr基金属 - 有机骨架（MOF）化学传感器。 还提供了使用化学传感器制备化学传感器的方法和用于检测，识别，去除和分离重金属的方法。

公开(公告)号：WO2013022494A3

公开(公告)日：2014-05-01

申请号：PCT/US2012031491

申请日：2012-03-30

Applicant: MASSACHUSETTS INST TECHNOLOGY ,  SWAGER TIMOTHY M ,  ANDREW TRISHA L

Inventor： SWAGER TIMOTHY M ,  ANDREW TRISHA L

IPC: G01N33/00 ,  C07D219/00

CPC classification number: G01N21/643 ,  G01N21/6408 ,  G01N2021/6439 ,  G01N2021/6441 ,  Y10T436/14 ,  Y10T436/147777 ,  Y10T436/17 ,  Y10T436/173845 ,  Y10T436/174614 ,  Y10T436/177692

Abstract: Sensors and methods for determination of analytes are provided. Analytes including explosives (e.g., RDX or PETN) may be determined by monitoring, for example, a change in an optical signal of a material upon exposure to the analyte. In some embodiments, the analyte and the material may interact via a chemical reaction to form a new emissive species. Embodiments described herein may provide inexpensive sensors with high selectivity and sensitivity.

Abstract translation: 提供了测定分析物的传感器和方法。 包括爆炸物（例如RDX或PETN）的分析物可以通过监测例如暴露于分析物中的材料的光学信号的变化来确定。 在一些实施方案中，分析物和材料可以经由化学反应相互作用以形成新的发射物质。 本文描述的实施例可以提供具有高选择性和灵敏度的廉价传感器。

公开(公告)号：WO2013125675A1

公开(公告)日：2013-08-29

申请号：PCT/JP2013/054488

申请日：2013-02-22

Applicant: 学校法人慶應義塾 ,  株式会社ヤクルト本社

Inventor： 谷川原　祐介 ,  西牟田　章戸 ,  津崎　盾哉 ,  高橋　寛行

IPC: G01N33/68 ,  A61K31/282 ,  A61K31/513 ,  A61K45/00 ,  A61P35/00 ,  A61P43/00 ,  G01N33/15 ,  G01N33/50

CPC classification number: G01N33/57484 ,  A61K31/282 ,  A61K31/513 ,  A61K31/555 ,  A61K45/06 ,  A61K47/18 ,  A61K47/183 ,  A61K47/26 ,  G01N33/574 ,  G01N33/6848 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/52 ,  Y10T436/143333 ,  Y10T436/147777 ,  Y10T436/163333 ,  Y10T436/173845 ,  Y10T436/201666 ,  A61K2300/00

Abstract: 　個々の患者の治療反応性を判別できる抗がん剤感受性判定マーカー及びそれを利用する新たながん治療手段を提供する。　アミノ酸代謝系上の物質、核酸代謝系上の物質、ペントースリン酸経路上の物質、解糖系上の物質、ＴＣＡ回路上の物質、ポリアミン代謝系上の物質並びに７，８－Ｄｉｈｙｄｒｏｂｉｏｐｔｅｒｉｎ、６－Ｐｈｏｓｐｈｏｇｌｕｃｏｎｉｃ　ａｃｉｄ、Ｂｕｔｙｒｉｃ　ａｃｉｄ、Ｔｒｉｅｔｈａｎｏｌａｍｉｎｅ、１－Ｍｅｔｈｙｌｎｉｃｏｔｉｎａｍｉｄｅ、ＮＡＤＨ、ＮＡＤ ＋ 及びそれら分子が関与する代謝系上の物質から選ばれる１以上の分子からなる、オキサリプラチン又はその塩とフルオロウラシル又はその塩を含む抗がん剤の感受性判定マーカー。

Abstract translation: 提供了可以区分对个体患者的治疗的反应性的抗癌敏感性决定标记物，以及使用其的新型癌症治疗手段。 用于测定包括奥沙利铂或其盐以及氟尿嘧啶或其盐的抗癌药敏感性的标记物包含至少一种选自氨基酸代谢物质，核酸代谢物质，戊糖磷酸途径物质，糖酵解的分子 物质，TCA循环物质，多胺代谢物质和涉及与7,8-二氢生物蝶呤，6-磷酸葡萄糖酸，丁酸，三乙醇胺，1-甲基烟酰胺，NADH，NAD +及其分子相关的代谢系统的物质。

公开(公告)号：WO2013103841A1

公开(公告)日：2013-07-11

申请号：PCT/US2013/020316

申请日：2013-01-04

Applicant: CLINICAL REFERENCE LABORATORY, INC.

Inventor： KUNTZ, David, J. ,  HERRERA, Michael, J.

IPC: G01N30/72 ,  G01N30/02 ,  G01N33/483

CPC classification number: G01N33/946 ,  G01N2560/00 ,  Y10T436/173845

Abstract: Methods for the chiral separation and quantitative determination of the d - and l - enantiomers for amphetamine and methamphetamine in bodily fluids and tissues are provided. The method comprises providing a bodily fluid or tissue sample from a subject, extracting target analyte(s) from the sample, followed by eluting on a liquid chromatography column comprising a chiral stationary phase to yield an eluent, which is then analyzed for the presence of the analytes using a mass analyzer.

Abstract translation: 提供了手性分离和定量测定体液和组织中苯丙胺和甲基苯丙胺的d-和l-对映异构体的方法。 该方法包括从受试者提供体液或组织样品，从样品中提取目标分析物，然后在包含手性固定相的液相色谱柱上洗脱以产生洗脱剂，然后分析其中是否存在 使用质谱仪的分析物。

公开(公告)号：WO2013014286A3

公开(公告)日：2013-04-04

申请号：PCT/EP2012064823

申请日：2012-07-27

Applicant: METANOMICS GMBH ,  RUPRECHT KARLS UNIVERISTAET HEIDELBERG ,  RESZKA REGINA ,  FUHRMANN JENS ,  KASTLER JUERGEN ,  BETHAN BIANCA ,  KLUTTIG MARTIN ,  KATUS HUGO ,  FREY NORBERT ,  WOLF JOHANNA ,  WEIS TANJA

Inventor： RESZKA REGINA ,  FUHRMANN JENS ,  KASTLER JUERGEN ,  BETHAN BIANCA ,  KLUTTIG MARTIN ,  KATUS HUGO ,  FREY NORBERT ,  WOLF JOHANNA ,  WEIS TANJA

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N30/72 ,  G01N30/8668 ,  G01N33/50 ,  G01N33/62 ,  G01N33/6806 ,  G01N33/743 ,  G01N33/92 ,  G01N2030/3076 ,  G01N2030/8813 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2560/00 ,  G01N2800/325 ,  G01N2800/56 ,  Y10T436/143333 ,  Y10T436/144444 ,  Y10T436/145555 ,  Y10T436/146666 ,  Y10T436/147777 ,  Y10T436/148888 ,  Y10T436/163333 ,  Y10T436/171538 ,  Y10T436/173845 ,  Y10T436/200833 ,  Y10T436/201666 ,  Y10T436/203332 ,  Y10T436/21

Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject and a method for monitoring progression or regression of heart failure in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

Abstract translation: 本发明涉及诊断方法领域。 具体地，本发明考虑了用于诊断受试者的心力衰竭的方法和用于监测受试者的心力衰竭进展或消退的方法。 本发明还涉及用于执行上述方法的工具，例如诊断装置。

公开(公告)号：WO2013038369A1

公开(公告)日：2013-03-21

申请号：PCT/IB2012/054790

申请日：2012-09-14

Applicant: BASF SE ,  BASF (China) Company Limited ,  KAMP, Hennicke ,  WALK, Tilmann B. ,  RAVENZWAAY, Bennard van ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  WIEMER, Jan C. ,  LOOSER, Ralf ,  HEROLD, Michael, Manfred ,  PROKOUDINE, Alexandre

Inventor： KAMP, Hennicke ,  WALK, Tilmann B. ,  RAVENZWAAY, Bennard van ,  MELLERT, Werner ,  FABIAN, Eric ,  STRAUSS, Volker ,  WIEMER, Jan C. ,  LOOSER, Ralf ,  HEROLD, Michael, Manfred ,  PROKOUDINE, Alexandre

IPC: G01N33/53

CPC classification number: G01N33/5014 ,  G01N33/62 ,  G01N33/6893 ,  G01N33/70 ,  G01N33/92 ,  G01N2500/04 ,  G01N2800/347 ,  Y10T436/171538 ,  Y10T436/173845 ,  Y10T436/24

Abstract: The present invention pertains to the field of diagnostics for kidney toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it discloses a method for diagnosing kidney toxicity. It also discloses a method for determining whether a compound is capable of inducing such kidney toxicity in a subject and a method of identifying a drug for treating kidney toxicity. Furthermore, the present invention discloses a device and a kit for diagnosing kidney toxicity.

Abstract translation: 本发明涉及用于化学化合物的危险分层的肾毒性和毒理学评估的诊断领域。 具体地说，它公开了一种诊断肾毒性的方法。 它还公开了一种用于确定化合物是否能够在受试者中诱导这种肾毒性的方法以及鉴定用于治疗肾毒性的药物的方法。 此外，本发明公开了一种用于诊断肾毒性的装置和试剂盒。

公开(公告)号：WO2013001534A1

公开(公告)日：2013-01-03

申请号：PCT/IL2012/050221

申请日：2012-06-27

Applicant: MISTRAL DETECTION LTD. ,  AMISAR, Shai

Inventor： AMISAR, Shai

IPC: G01N21/76 ,  C07C205/06 ,  C07C205/07 ,  C07C205/35 ,  C07C205/44 ,  C07C205/55

CPC classification number: G01N33/227 ,  A61F9/007 ,  A61F9/00718 ,  A61N1/403 ,  G01N21/78 ,  Y10T436/170769 ,  Y10T436/173076 ,  Y10T436/173845 ,  Y10T436/178459 ,  Y10T436/19 ,  Y10T436/206664

Abstract: A method for the detection of explosives using a single sample. The explosives include nitro aliphatic and nitro aromatic-based explosives. The method includes steps which require different pHs to discriminate between these types of explosives and at least in the detection step of the nitro aliphatic explosive requires the presence of a nitro aromatic compound. A kit for detecting explosives which includes a medium for collecting a sample, a base optionally impregnated on the medium; and a nitro aromatic solution for detecting a nitro aliphatic explosive by contacting the solution with the sample on the medium. A reagent including a nitro aromatic compound, having one or more additional electron withdrawing groups, in the presence of a basic compound usable for detecting nitro aliphatic explosives.

Abstract translation: 使用单个样品检测炸药的方法。 爆炸物包括硝基脂肪和硝基芳香族基爆炸物。 该方法包括需要不同pH来区分这些类型的爆炸物的步骤，并且至少在硝基脂族炸药的检测步骤中需要存在硝基芳族化合物。 用于检测爆炸物的试剂盒，其包括用于收集样品的介质，任选地浸渍在介质上的基底; 以及硝基芳族溶液，用于通过使溶液与介质上的样品接触来检测硝基脂肪族炸药。 在含有可用于检测硝基脂族炸药的碱性化合物的存在下，包括具有一个或多个另外的吸电子基团的硝基芳族化合物的试剂。

公开(公告)号：WO2011156846A1

公开(公告)日：2011-12-22

申请号：PCT/AU2011/000669

申请日：2011-06-01

Applicant: GENEASYS PTY LTD ,  SILVERBROOK, Kia ,  MOINI, Alireza ,  AZIMI, Mehdi

Inventor： SILVERBROOK, Kia ,  MOINI, Alireza ,  AZIMI, Mehdi

IPC: B01B1/00 ,  C12M1/00 ,  G01N21/62 ,  B81B7/00 ,  C12Q1/68

CPC classification number: C12Q1/68 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0883 ,  B01L2300/10 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0633 ,  B01L2400/0677 ,  B01L2400/0688 ,  F16K99/003 ,  F16K99/0036 ,  Y10T137/0352 ,  Y10T137/0391 ,  Y10T137/1044 ,  Y10T137/206 ,  Y10T137/2076 ,  Y10T137/2202 ,  Y10T436/107497 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/145555 ,  Y10T436/173845 ,  Y10T436/203332 ,  Y10T436/25 ,  Y10T436/25375

Abstract: A microfluidic device for simultaneous detection of multiple conditions in a patient, the microfluidic device having an inlet for receiving a sample of biological material drawn from the patient, a microsystems technologies (MST) layer with a detection section having an array of hybridization chambers, the hybridization chambers comprising probes for detecting target molecules, the target molecules being indicative of medical conditions in the patient, and a photodetection section for detecting the probe-target complexes, wherein the photodetection section comprises a plurality of photodiodes such that each hybridization chamber has a corresponding photodiode.

Abstract translation: 一种用于同时检测患者多个病症的微流体装置，所述微流体装置具有用于接收从患者抽取的生物材料的样本的入口，具有检测部分的具有杂交室阵列的微系统技术（MST）层， 杂交室，其包括用于检测靶分子的探针，靶分子指示患者的医学状况，以及用于检测探针 - 靶复合物的光检测部分，其中光检测部分包括多个光电二极管，使得每个杂交室具有相应的 光电二极管。

公开(公告)号：WO2011156845A1

公开(公告)日：2011-12-22

申请号：PCT/AU2011/000668

申请日：2011-06-01

Applicant: GENEASYS PTY LTD ,  FACER, Geoffrey Richard ,  SILVERBROOK, Kia ,  AZIMI, Mehdi

Inventor： FACER, Geoffrey Richard ,  SILVERBROOK, Kia ,  AZIMI, Mehdi

IPC: B81B7/02 ,  C12Q1/00 ,  G01N33/50

CPC classification number: C12Q1/68 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0883 ,  B01L2300/10 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0633 ,  B01L2400/0677 ,  B01L2400/0688 ,  F16K99/003 ,  F16K99/0036 ,  Y10T137/0352 ,  Y10T137/0391 ,  Y10T137/1044 ,  Y10T137/206 ,  Y10T137/2076 ,  Y10T137/2202 ,  Y10T436/107497 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/145555 ,  Y10T436/173845 ,  Y10T436/203332 ,  Y10T436/25 ,  Y10T436/25375

Abstract: A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material including DNA and RNA, a supporting substrate, a plurality of reagent reservoirs, a first incubation section, the first incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, a second incubation section, the second incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material in parallel with the first incubation section, a first nucleic acid amplification section downstream of the first incubation section for amplifying at least some of the genetic material, and, a second nucleic acid amplification section downstream of the second incubation section for amplifying at least some of the genetic material in parallel with the first nucleic acid amplification section, wherein, the first incubation section, the second incubation section, the first nucleic acid amplification section and the second nucleic acid amplification section are all supported on the supporting substrate.

Abstract translation: 一种用于遗传分析生物样品的实验室（LOC）装置，所述LOC装置具有用于接收含有包含DNA和RNA的遗传物质的样品的入口，支持基底，多个试剂储存器，第一 孵育部分，第一孵育部分与含有用于与遗传物质进行酶反应的酶的试剂储存器流体连通，第二孵育部分，第二孵育部分与含有酶酶的试剂储存器流体连通 与第一孵育部分平行的遗传物质的反应，第一孵育部分下游的第一核酸扩增部分，用于扩增至少一部分遗传物质;以及在第二孵育部分下游的第二核酸扩增部分，用于 与第一核酸扩增子平行扩增至少一些遗传物质 其中，第一孵育部分，第二孵育部分，第一核酸扩增部分和第二核酸扩增部分都支撑在支撑基底上。