公开(公告)号：WO2008111020A2

公开(公告)日：2008-09-18

申请号：PCT/IB2008/050979

申请日：2008-03-14

Applicant: RANBAXY LABORATORIES LIMITED ,  CHAKRABARTI, Anjan ,  SURASE, Yogesh, Baban ,  JADHAV, Jitendra, Sambhaji ,  DAS, Biswajit ,  UPADHYAY, Dilip

Inventor： CHAKRABARTI, Anjan ,  SURASE, Yogesh, Baban ,  JADHAV, Jitendra, Sambhaji ,  DAS, Biswajit ,  UPADHYAY, Dilip

CPC classification number: C07H17/00 ,  C07H17/08

Abstract: The present invention provides macrolide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided, are the processes for preparing the compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.

Abstract translation: 本发明提供了可用作抗菌剂的大环内酯衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧菌引起的疾病或更有针对性地对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉沙拉菌，衣原体属，支原体 军团菌属，分枝杆菌属，螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了用于制备本文公开的化合物的方法，含有本文公开的化合物的药物组合物，以及治疗细菌感染的方法。

公开(公告)号：WO2007060518A2

公开(公告)日：2007-05-31

申请号：PCT/IB2006003298

申请日：2006-11-21

Applicant: RANBAXY LAB LTD ,  DAS BISWAJIT ,  CHAKRABARTI ANJAN ,  KUMAR RAJESH ,  VENKATARAMANAN RAMADASS ,  HAJARE ATUL KASHINATH ,  BANDYOPADHYAY ANISH ,  KATOCH RITA ,  KAPKOTI GOBIND SINGH ,  SURASE YOGESH BABAN ,  SALMAN MOHAMMAD ,  UPADHYAY DILIP J

Inventor： DAS BISWAJIT ,  CHAKRABARTI ANJAN ,  KUMAR RAJESH ,  VENKATARAMANAN RAMADASS ,  HAJARE ATUL KASHINATH ,  BANDYOPADHYAY ANISH ,  KATOCH RITA ,  KAPKOTI GOBIND SINGH ,  SURASE YOGESH BABAN ,  SALMAN MOHAMMAD ,  UPADHYAY DILIP J

CPC classification number: C07H17/08

Abstract: Provided herein are ketolide derivatives, which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae, Propionibacterium acnes or any combination thereof. Also provided are processes for preparation of compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections.

Abstract translation: 本文提供了可用作抗菌剂的酮内酯衍生物。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉萨氏菌，衣原体属，支原体 ，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属，痤疮丙酸杆菌或其任何组合。 还提供了制备本文所述的化合物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：WO2006080954A1

公开(公告)日：2006-08-03

申请号：PCT/US2005/027875

申请日：2005-07-28

Applicant: DAS, Biswajit ,  SALMAN, Mohammad ,  HAJARE, Atul, Kashinath ,  VENKATARAMANAN, Ramadass ,  KATOCH, Rita ,  KUMAR, Rajesh ,  KAPKOTI, Gobind, Singh ,  CHAKRABARTI, Anjan ,  BANDYOPADHYAY, Anish ,  KURHADE, Santosh, Haribhau ,  SURASE, Yogesh, Baban ,  RATTAN, Ashok

Inventor： DAS, Biswajit ,  SALMAN, Mohammad ,  HAJARE, Atul, Kashinath ,  VENKATARAMANAN, Ramadass ,  KATOCH, Rita ,  KUMAR, Rajesh ,  KAPKOTI, Gobind, Singh ,  CHAKRABARTI, Anjan ,  BANDYOPADHYAY, Anish ,  KURHADE, Santosh, Haribhau ,  SURASE, Yogesh, Baban ,  RATTAN, Ashok

IPC: C07H17/00 ,  A61K31/7052 ,  A61P31/04

CPC classification number: C07H17/00

Abstract: The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae. Also provided are processes for preparing siuch ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.

Abstract translation: 本发明提供可用作抗菌剂的酮内酯衍生物。 特别地，本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌， 衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属。 还提供了制备西罗汉酮内酯衍生物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：WO2008111020A3

公开(公告)日：2008-11-13

申请号：PCT/IB2008050979

申请日：2008-03-14

Applicant: RANBAXY LAB LTD ,  CHAKRABARTI ANJAN ,  SURASE YOGESH BABAN ,  JADHAV JITENDRA SAMBHAJI ,  DAS BISWAJIT ,  UPADHYAY DILIP

Inventor： CHAKRABARTI ANJAN ,  SURASE YOGESH BABAN ,  JADHAV JITENDRA SAMBHAJI ,  DAS BISWAJIT ,  UPADHYAY DILIP

IPC: C07H17/00 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/04 ,  C07H17/08

CPC classification number: C07H17/00 ,  C07H17/08

Abstract: The present invention provides macrolide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided, are the processes for preparing the compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.

Abstract translation: 本发明提供可用作抗菌剂的大环内酯衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫萨卡氏菌，衣原体属，支原体 ，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了制备本文公开的化合物的方法，包含本文公开的化合物的药物组合物，以及治疗细菌感染的方法。

公开(公告)号：WO2008099368A1

公开(公告)日：2008-08-21

申请号：PCT/IB2008/050568

申请日：2008-02-15

Applicant: RANBAXY LABORATORIES LIMITED ,  CHAKRABARTI, Anjan ,  SURASE, Yogesh, Baban ,  KAKADE, Balasaheb ,  DAS, Biswajit ,  UPADHYAY, Dilip J.

Inventor： CHAKRABARTI, Anjan ,  SURASE, Yogesh, Baban ,  KAKADE, Balasaheb ,  DAS, Biswajit ,  UPADHYAY, Dilip J.

IPC: C07H17/08 ,  A61K31/7028 ,  A61P31/04

CPC classification number: C07H17/08

Abstract: The present invention provides macrolide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxella spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.

Abstract translation: 本发明提供可用作抗菌剂的大环内酯衍生物。 本文公开的化合物可用于治疗或预防革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉氏菌属，衣原体属，支原体 ，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了制备本文公开的化合物的方法，含有本文公开的化合物的药物组合物，以及治疗细菌感染的方法。

公开(公告)号：WO2007060518A3

公开(公告)日：2007-05-31

申请号：PCT/IB2006/003298

申请日：2006-11-21

Applicant: RANBAXY LABORATORIES LIMITED ,  DAS, Biswajit ,  CHAKRABARTI, Anjan ,  KUMAR, Rajesh ,  VENKATARAMANAN, Ramadass ,  HAJARE, Atul Kashinath ,  BANDYOPADHYAY, Anish ,  KATOCH, Rita ,  KAPKOTI, Gobind Singh ,  SURASE, Yogesh Baban ,  SALMAN, Mohammad ,  UPADHYAY, Dilip J.

Inventor： DAS, Biswajit ,  CHAKRABARTI, Anjan ,  KUMAR, Rajesh ,  VENKATARAMANAN, Ramadass ,  HAJARE, Atul Kashinath ,  BANDYOPADHYAY, Anish ,  KATOCH, Rita ,  KAPKOTI, Gobind Singh ,  SURASE, Yogesh Baban ,  SALMAN, Mohammad ,  UPADHYAY, Dilip J.

IPC: C07H17/08 ,  A61K31/7052 ,  A61P31/04

Abstract: Provided herein are ketolide derivatives, which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae, Propionibacterium acnes or any combination thereof. Also provided are processes for preparation of compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections.