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    ANTIBACTERIAL AGENTS
    7.
    发明申请
    ANTIBACTERIAL AGENTS 审中-公开
    抗菌剂

    公开(公告)号：WO2006035301A2

    公开(公告)日：2006-04-06

    申请号：PCT/IB2005002894

    申请日：2005-09-27

    Applicant: RANBAXY LAB LTD ,  DAS BISWAJIT ,  KATOCH RITA ,  HAJARE ATUL KASHINATH ,  BANDYOPADHYAY ANISH ,  KURHADE SANTOSH HARIBHAU ,  RATHY SUJATA ,  RATTAN ASHOK

    Inventor： DAS BISWAJIT ,  KATOCH RITA ,  HAJARE ATUL KASHINATH ,  BANDYOPADHYAY ANISH ,  KURHADE SANTOSH HARIBHAU ,  RATHY SUJATA ,  RATTAN ASHOK

    CPC classification number: C07H17/08

    Abstract: The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, pharmaceutical compositions thereof, and method of treating bacterial infections.

    Abstract translation: 本发明提供可用作抗菌剂的酰化物衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，更具体地针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，马克拉斯氏菌属，衣原体属，衣原体属。 ，支原体属（Mycoplasm），军团菌属（Legionella spp。），分枝杆菌属（Mycobacterium），幽门螺杆菌属（Clostridium），拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其组合。 还提供了制备本文公开的化合物的方法，其药物组合物和治疗细菌感染的方法。

    KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS
    9.
    发明申请
    KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
    胶体衍生物作为抗菌剂

    公开(公告)号：WO2006129257A3

    公开(公告)日：2007-02-08

    申请号：PCT/IB2006051686

    申请日：2006-05-26

    Applicant: RANBAXY LAB LTD ,  DAS BISWAJIT ,  CHAKRABARTI ANJAN ,  KAPKOTI GOBIND SINGH ,  HAJARE ATUL KASHINATH ,  KATOCH RITA ,  RATTAN ASHOK

    Inventor： DAS BISWAJIT ,  CHAKRABARTI ANJAN ,  KAPKOTI GOBIND SINGH ,  HAJARE ATUL KASHINATH ,  KATOCH RITA ,  RATTAN ASHOK

    IPC: C07H17/08 ,  A61K31/7048

    CPC classification number: C07H17/08

    Abstract: The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae. Also provided are processes for preparing such ketolide. derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections. The compounds have the following structure, Formula (I), wherein R can be Formula (II), (wherein Z i can be hydrogen or melhyl, Z 2 can be hydrogen, halogen, C 1-3 alkyl, C 1-3 alkoxy, amino, nitro, cyano or amido, Z 3 can be hydrogen, fluorine, chlorine, bromine or iodine, X 1 can be CR 4 , CR 4 R' 4 N, NR 4 , O or S, X 2 can be CR 4 or N wherein R 4 and R' 4 independently in each occurrence can be hydrogen or C 1-3 alky, R 2 and R 3 can be independently Formula (III), wherein, X 3 -X 13 can be independenËy C(R 4 ) 0-2 , N(R 4 ) 0-1 , O or S, R 5 -R 10 can be independently hydrogen, halogen, C 1-3 alkyl, C 1-3 alkoxy, amino, nilro, cyano, aryl or heteroaryl), Y is hydrogen or methyl, and is an optional single bond.

    Abstract translation: 本发明提供可用作抗菌剂的酮内酯衍生物。 特别地，本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，马克拉斯氏菌属，衣原体属 ，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属。 还提供了制备这种酮内酯的方法。 衍生物，其药物组合物，以及治疗细菌感染的方法。 这些化合物具有下列结构式（I），其中R可以是式（II），其中Z可以是氢或蜜胺，Z 2可以是氢 卤素，C 1-3烷基，C 1-3烷氧基，氨基，硝基，氰基或酰胺基，Z 3可以是氢， 氟，氯，溴或碘，X 1可以是CR 4，CR 4 R 4，N， NR 4，O或S，X 2可以是CR 4或N，其中R 4和R' 在每次出现时独立地可以是氢或C 1-3烷基，R 2和R 3可以独立地独立地 式（III），其中X 3 -X 13可以独立地是C（R 4）0-2 ，N（R 4）0-1，O或S，R 5 -R 10可以是 独立地是氢，卤素，C 1-3烷基，C 1-3烷氧基，氨基，腈基，氰基，芳基或杂芳基），Y是氢或甲基，并且是 一个可选单键。

    KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS
    10.
    发明申请
    KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
    胶体衍生物作为抗菌剂

    公开(公告)号：WO2006129257A2

    公开(公告)日：2006-12-07

    申请号：PCT/IB2006/051686

    申请日：2006-05-26

    Applicant: RANBAXY LABORATORIES LIMITED ,  DAS, Biswajit ,  CHAKRABARTI, Anjan ,  KAPKOTI, Gobind, Singh ,  HAJARE, Atul, Kashinath ,  KATOCH, Rita ,  RATTAN, Ashok

    Inventor： DAS, Biswajit ,  CHAKRABARTI, Anjan ,  KAPKOTI, Gobind, Singh ,  HAJARE, Atul, Kashinath ,  KATOCH, Rita ,  RATTAN, Ashok

    IPC: C07H17/08 ,  A61K31/7048

    CPC classification number: C07H17/08

    Abstract: The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae. Also provided are processes for preparing such ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.

    Abstract translation: 本发明提供可用作抗菌剂的酮内酯衍生物。 特别地，本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，马克拉斯氏菌属，衣原体属 ，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属。 还提供了制备这种酮内酯衍生物的方法，其药物组合物和治疗细菌感染的方法。

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