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公开(公告)号：WO2006092032A3
公开(公告)日：2006-11-02
申请号：PCT/BR2006000037
申请日：2006-03-03
申请人： UNIV RIO DE JANEIRO , DE LACERDA BARREIRO ELIEZER DE , MANSSOUR FRAGA CARLOS ALBERTO , ZAPATA SUDO GISELE , TAKASHI SUDO ROBERTO , MENEGATTI RICARDO
发明人： DE LACERDA BARREIRO ELIEZER DE , MANSSOUR FRAGA CARLOS ALBERTO , ZAPATA SUDO GISELE , TAKASHI SUDO ROBERTO , MENEGATTI RICARDO
IPC分类号： C07D471/12 , C07D471/14 , A61K31/437 , A61P25/00 , A61P25/04 , A61P25/28
CPC分类号： A61K31/437 , C07D471/14
摘要： The present invention is related to new derivatives of 1-methyl-3,6,7,8- tetrahydropirazolo[3,4-b]pirrolo[4,3-d]piridin-6,8-dione nucleus, preferably heterocyclic derivatives, acting as hypnotics and analgesic in the central nervous system, being useful in the treatment of anxiety and central hyperalgesia, including: anxiety relief, central hyperalgesia relief in mammals, preferably humans. It is also described pharmaceutical compositions containing said compounds and preparation processes.
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2.发明申请COMPOUND WITH ANESTHETICS ACTIVITY, METHODS FOR ITS PRODUCTION AN PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开具有麻醉活性的化合物，其生产包含其的药物组合物的方法
公开(公告)号：WO2008134840A2
公开(公告)日：2008-11-13
申请号：PCT/BR2008/000145
申请日：2008-05-05
申请人： UNIVERSIDADE FEDERAL DE PERNAMBUCO - UFPE , UNIVERSIDADE FEDERAL DO RIO DE JANEIRO - UFRJ , DA ROCHA PITTA, Ivan , DO CARMO ALVES DE LIMA, Maria , GONÇALVES DA SILVA, Teresinha , ZAPATA SUDO, Gisele , LINS GALDINO, Suely , TAKASHI SUDO, Roberto
发明人： DA ROCHA PITTA, Ivan , DO CARMO ALVES DE LIMA, Maria , GONÇALVES DA SILVA, Teresinha , ZAPATA SUDO, Gisele , LINS GALDINO, Suely , TAKASHI SUDO, Roberto
IPC分类号： C07D233/72
CPC分类号： C07D233/74
摘要： The present invention is related to a new series of chemical compounds, namely 3-benzyl-imidazolidine-2,4-dione substituted in the position 2 and/or 6 of benzyl ring by halogens as presented to the molecule named LPSF-PT-31, GIRSUPAN and its therapeutic use as drug with analgesic, sedative and adjuvant of anesthetics activities. The invention is also related to a process for production of said compounds as well as pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及新的一系列化合物，即通过被称为LPSF-PT-31的分子的卤素在苄基的2位和/或6位上被取代的3-苄基 - 咪唑烷-2,4-二酮 ，GIRSUPAN及其作为药物的治疗用途，具有止痛，镇静和佐剂的麻醉活性。 本发明还涉及所述化合物的制备方法以及包含它们的药物组合物。
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公开(公告)号：WO2006017921A8
公开(公告)日：2007-04-26
申请号：PCT/BR2005000168
申请日：2005-08-19
申请人： UNIV RIO DE JANEIRO , BARREIRO ELIEZER DE JESUS DE L , KUMMERLE ARTHUR EUGEN , GODINHO SILVA ALEXANDRE , ZAPATA SUDO GISELE , FRAGA CARLOS ALBERTO MANSSOUR , TAKASHI SUDO ROBERTO
IPC分类号： C07D409/12 , A61K31/357 , A61K31/381 , A61P9/04 , A61P21/02
CPC分类号： C07D409/12
摘要： This invention refers to substances able to cause selective muscle relaxation, pharmaceutical compositions containing such compounds and their use in the treatment of muscle tissue diseases, with such compounds complying with the general formula (I).
摘要翻译： 本发明涉及能够引起选择性肌肉松弛的物质，含有这些化合物的药物组合物及其在治疗肌肉组织疾病中的用途，具有符合通式（I）的化合物。
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4.发明申请PHARMACEUTICAL COMPOSITIONS CONTAINING 1-METHYL-3,6,7,8-TETRAHYDROPIRAZOLO[3,4-b]PIRROLO[4,3-d]PYRIDINE-6,8-DIONE DERIVATIVES, USE, AND PROCESS FOR PREPARING THEM 审中-公开含有1-甲基-3,6,7,8-四氢呋喃并[3,4-b]吡啶并[4,3-d]吡啶-6,8-二酮衍生物的药物组合物，用途及其制备方法
公开(公告)号：WO2006092032A2
公开(公告)日：2006-09-08
申请号：PCT/BR2006/000037
申请日：2006-03-03
申请人： UNIVERSIDADE FEDERAL DO RIO DE JANEIRO - UFRJ , DE LACERDA BARREIRO, Eliezer de Jesus , MANSSOUR FRAGA, Carlos Alberto , ZAPATA SUDO, Gisele , TAKASHI SUDO, Roberto , MENEGATTI, Ricardo
发明人： DE LACERDA BARREIRO, Eliezer de Jesus , MANSSOUR FRAGA, Carlos Alberto , ZAPATA SUDO, Gisele , TAKASHI SUDO, Roberto , MENEGATTI, Ricardo
IPC分类号： C07D471/12 , C07D471/14 , A61K31/437 , A61P25/04
CPC分类号： A61K31/437 , C07D471/14
摘要： The present invention is related to new derivatives of 1-methyl-3,6,7,8- tetrahydropirazolo[3,4-b]pirrolo[4,3-d]piridin-6,8-dione nucleus, preferably heterocyclic derivatives, acting as hypnotics and analgesic in the central nervous system, being useful in the treatment of anxiety and central hyperalgesia, including: anxiety relief, central hyperalgesia relief in mammals, preferably humans. It is also described pharmaceutical compositions containing said compounds and preparation processes.
摘要翻译： 本发明涉及1-甲基-3,6,7,8-四氢吡拉唑并[3,4-b]吡咯并[4,3-d]吡啶-6,8-二酮核的新衍生物，优选杂环衍生物， 在中枢神经系统中作为安眠药和止痛剂，可用于治疗焦虑和中枢性痛觉过敏，包括：焦虑缓解，哺乳动物，优选人类的中枢痛觉过敏缓解。 还描述了含有所述化合物和制备方法的药物组合物。
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5.发明申请COMPOUND WITH ANESTHETICS ACTIVITY, METHODS FOR ITS PRODUCTION AN PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开具有麻醉活性的化合物，其生产包含其的药物组合物的方法
公开(公告)号：WO2008134840A3
公开(公告)日：2009-01-29
申请号：PCT/BR2008000145
申请日：2008-05-05
申请人： UNIV FED DE PERNAMBUCO UFPE , UNIV RIO DE JANEIRO , DA ROCHA PITTA IVAN , DO CARMO ALVES DE LIMA MARIA , GONCALVES DA SILVA TERESINHA , ZAPATA SUDO GISELE , LINS GALDINO SUELY , TAKASHI SUDO ROBERTO
发明人： DA ROCHA PITTA IVAN , DO CARMO ALVES DE LIMA MARIA , GONCALVES DA SILVA TERESINHA , ZAPATA SUDO GISELE , LINS GALDINO SUELY , TAKASHI SUDO ROBERTO
IPC分类号： C07D233/72
CPC分类号： C07D233/74
摘要： The present invention is related to a new series of chemical compounds, namely 3-benzyl-imidazolidine-2,4-dione substituted in the position 2 and/or 6 of benzyl ring by halogens as presented to the molecule named LPSF-PT-31, GIRSUPAN and its therapeutic use as drug with analgesic, sedative and adjuvant of anesthetics activities. The invention is also related to a process for production of said compounds as well as pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及新的一系列化合物，即通过被称为LPSF-PT-31的分子的卤素在苄基的2位和/或6位上被取代的3-苄基 - 咪唑烷-2,4-二酮 ，GIRSUPAN及其作为药物的治疗用途，具有止痛，镇静和佐剂的麻醉活性。 本发明还涉及所述化合物的制备方法以及包含它们的药物组合物。
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公开(公告)号：WO2006017921A1
公开(公告)日：2006-02-23
申请号：PCT/BR2005/000168
申请日：2005-08-19
申请人： UNIVERSIDADE FEDERAL DO RIO DE JANEIRO - UFRJ , BARREIRO, Eliezer de Jesus de Lacerda , KUMMERLE, Arthur Eugen , GODINHO SILVA, Alexandre , ZAPATA SUDO, Gisele , FRAGA, Carlos Alberto Manssour , TAKASHI SUDO, Roberto
IPC分类号： C07D409/12
CPC分类号： C07D409/12
摘要： This invention refers to substances able to cause selective muscle relaxation, pharmaceutical compositions containing such compounds and their use in the treatment of muscle tissue diseases, with such compounds complying with the general formula (I).
摘要翻译： 本发明涉及能够引起选择性肌肉松弛的物质，含有这些化合物的药物组合物及其在治疗肌肉组织疾病中的用途，具有符合通式（I）的化合物。
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7.发明申请PHARMACEUTICAL COMPOSITIONS CONTAINING 1-METHYL-3,6,7,8-TETRAHYDROPIRAZOLO[3,4-b]PIRROLO[4,3-d]PYRIDINE-6,8-DIONE DERIVATIVES, USE, AND PROCESS FOR PREPARING THEM 审中-公开含有1-甲基-3,6,7,8-四氢吡唑并[3,4-b]吡咯并[4,3-d]吡啶-6,8-二酮衍生物的药物组合物，其制备方法及其制备方法
公开(公告)号：WO2006092032B1
公开(公告)日：2006-12-28
申请号：PCT/BR2006000037
申请日：2006-03-03
申请人： UNIV RIO DE JANEIRO , DE LACERDA BARREIRO ELIEZER DE , MANSSOUR FRAGA CARLOS ALBERTO , ZAPATA SUDO GISELE , TAKASHI SUDO ROBERTO , MENEGATTI RICARDO
发明人： DE LACERDA BARREIRO ELIEZER DE , MANSSOUR FRAGA CARLOS ALBERTO , ZAPATA SUDO GISELE , TAKASHI SUDO ROBERTO , MENEGATTI RICARDO
IPC分类号： C07D471/12 , C07D471/14 , A61K31/437 , A61P25/00 , A61P25/04 , A61P25/28
CPC分类号： A61K31/437 , C07D471/14
摘要： The present invention is related to new derivatives of 1-methyl-3,6,7,8- tetrahydropirazolo[3,4-b]pirrolo[4,3-d]piridin-6,8-dione nucleus, preferably heterocyclic derivatives, acting as hypnotics and analgesic in the central nervous system, being useful in the treatment of anxiety and central hyperalgesia, including: anxiety relief, central hyperalgesia relief in mammals, preferably humans. It is also described pharmaceutical compositions containing said compounds and preparation processes.
摘要翻译： 本发明涉及1-甲基-3,6,7,8-四氢吡唑并[3,4-b]螺[4,3-d]哌啶-6,8-二酮核，优选杂环衍生物的新衍生物， 用作中枢神经系统中的催眠药和镇痛药，可用于治疗焦虑和中枢痛觉过敏，包括：在哺乳动物，优选人类中缓解焦虑，中枢痛觉过敏。 还描述了含有所述化合物和制备方法的药物组合物。
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