公开(公告)号：WO2012019134A2

公开(公告)日：2012-02-09

申请号：PCT/US2011/046810

申请日：2011-08-05

Applicant: BROWN UNIVERSITY ,  HUANG, Yongsong ,  APONTE, Jose C. ,  TAROZO, Rafael ,  DILLON, James

Inventor： HUANG, Yongsong ,  APONTE, Jose C. ,  TAROZO, Rafael ,  DILLON, James

IPC: B01J20/282 ,  B01J20/291 ,  G01N30/02 ,  C07C7/12 ,  B01D15/08

CPC classification number: B01J20/0262 ,  B01J20/289 ,  B01J20/291 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3236 ,  B01J2220/62

Abstract: Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.

Abstract translation: 本文提供了具有新型色谱材料的方法，组合物，装置和试剂盒，用于分离和鉴定有机分子和化合物，例如含有富电子官能团如碳 - 碳双键的分子和化合物。 所述方法，组合物和试剂盒包括具有含硫官能团的金属硫醇盐色谱介质（MTCM）或包含共价连接至载体介质的含硒官能团的金属硒酸盐色谱介质（MSCM），使得 含硫官能团或含硒官能团与至少一个金属原子结合。 MTCM和/或MSCM对具有一个或多个碳 - 碳双键的化合物具有亲和力和特异性，并且与传统培养基相比，对样品进行高效且快速的分离，产生纯化材料的非重叠峰。

公开(公告)号：WO2012019134A3

公开(公告)日：2012-05-31

申请号：PCT/US2011046810

申请日：2011-08-05

Applicant: UNIV BROWN ,  HUANG YONGSONG ,  APONTE JOSE C ,  TAROZO RAFAEL ,  DILLON JAMES

Inventor： HUANG YONGSONG ,  APONTE JOSE C ,  TAROZO RAFAEL ,  DILLON JAMES

IPC: B01J20/282 ,  B01D15/08 ,  B01J20/291 ,  C07C7/12 ,  G01N30/02

CPC classification number: B01J20/0262 ,  B01J20/289 ,  B01J20/291 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3236 ,  B01J2220/62

Abstract: Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.

Abstract translation: 本文提供了具有新型色谱材料的方法，组合物，装置和试剂盒，用于分离和鉴定有机分子和化合物，例如含有富含电子的官能团如碳 - 碳双键的分子和化合物。 方法，组合物和试剂盒包括含有含硫官能团的金属硫醇盐色谱介质（MTCM）或含有共价连接到载体介质上的含硒官能团的金属硒酸盐层析介质（MSCM），使得 含硫官能团或含硒官能团与至少一个金属原子结合。 MTCM和/或MSCM对具有一个或多个碳 - 碳双键的化合物具有亲和性和特异性，并且与传统介质相比，能够实现产生非重叠的纯化材料峰的样品的高效快速分离。