公开(公告)号：WO2012019134A3

公开(公告)日：2012-05-31

申请号：PCT/US2011046810

申请日：2011-08-05

Applicant: UNIV BROWN ,  HUANG YONGSONG ,  APONTE JOSE C ,  TAROZO RAFAEL ,  DILLON JAMES

Inventor： HUANG YONGSONG ,  APONTE JOSE C ,  TAROZO RAFAEL ,  DILLON JAMES

IPC: B01J20/282 ,  B01D15/08 ,  B01J20/291 ,  C07C7/12 ,  G01N30/02

CPC classification number: B01J20/0262 ,  B01J20/289 ,  B01J20/291 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3236 ,  B01J2220/62

Abstract: Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.

Abstract translation: 本文提供了具有新型色谱材料的方法，组合物，装置和试剂盒，用于分离和鉴定有机分子和化合物，例如含有富含电子的官能团如碳 - 碳双键的分子和化合物。 方法，组合物和试剂盒包括含有含硫官能团的金属硫醇盐色谱介质（MTCM）或含有共价连接到载体介质上的含硒官能团的金属硒酸盐层析介质（MSCM），使得 含硫官能团或含硒官能团与至少一个金属原子结合。 MTCM和/或MSCM对具有一个或多个碳 - 碳双键的化合物具有亲和性和特异性，并且与传统介质相比，能够实现产生非重叠的纯化材料峰的样品的高效快速分离。

公开(公告)号：WO2010019861A1

公开(公告)日：2010-02-18

申请号：PCT/US2009/053856

申请日：2009-08-14

Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. ,  UNIVERSIDAD PERUMA CAYETANO HEREDIA ,  INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD) ,  THE JOHNS HOPKINS UNIVERSITY ,  HAMMOND, Gerald, B. ,  APONTE, Jose, C. ,  GILMAN, Robert, H. ,  SAUVAIN, Michel, Henri-Auguste ,  VAISBERG, Abraham

Inventor： HAMMOND, Gerald, B. ,  APONTE, Jose, C. ,  GILMAN, Robert, H. ,  SAUVAIN, Michel, Henri-Auguste ,  VAISBERG, Abraham

IPC: A01N43/62

CPC classification number: C07C49/84 ,  C07C45/62 ,  C07C45/673 ,  C07C45/71 ,  C07C45/74 ,  C07D317/48 ,  C07D495/04

Abstract: Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).

Abstract translation: 本发明的实施方案提供化合物（例如式（I）化合物，式（II）化合物及其各种实施方案）。 还提供了包含这些化合物的组合物。 包括其制备方法。 此外，包括化合物的用途，例如施用和治疗疾病（例如癌症和感染）。

公开(公告)号：WO2012019134A2

公开(公告)日：2012-02-09

申请号：PCT/US2011/046810

申请日：2011-08-05

Applicant: BROWN UNIVERSITY ,  HUANG, Yongsong ,  APONTE, Jose C. ,  TAROZO, Rafael ,  DILLON, James

Inventor： HUANG, Yongsong ,  APONTE, Jose C. ,  TAROZO, Rafael ,  DILLON, James

IPC: B01J20/282 ,  B01J20/291 ,  G01N30/02 ,  C07C7/12 ,  B01D15/08

CPC classification number: B01J20/0262 ,  B01J20/289 ,  B01J20/291 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/3219 ,  B01J20/3236 ,  B01J2220/62

Abstract: Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.

Abstract translation: 本文提供了具有新型色谱材料的方法，组合物，装置和试剂盒，用于分离和鉴定有机分子和化合物，例如含有富电子官能团如碳 - 碳双键的分子和化合物。 所述方法，组合物和试剂盒包括具有含硫官能团的金属硫醇盐色谱介质（MTCM）或包含共价连接至载体介质的含硒官能团的金属硒酸盐色谱介质（MSCM），使得 含硫官能团或含硒官能团与至少一个金属原子结合。 MTCM和/或MSCM对具有一个或多个碳 - 碳双键的化合物具有亲和力和特异性，并且与传统培养基相比，对样品进行高效且快速的分离，产生纯化材料的非重叠峰。