公开(公告)号：WO2010016064A3

公开(公告)日：2010-05-06

申请号：PCT/IL2009000765

申请日：2009-08-05

Applicant: ROSETTA GENOMICS LTD ,  TEL HASHOMER MEDICAL INFRASTRU ,  ROSENFELD NITZAN ,  SPECTOR YAEL ,  FRIEDMAN EDDIE ,  DOTAN ZOHAR

Inventor： ROSENFELD NITZAN ,  SPECTOR YAEL ,  FRIEDMAN EDDIE ,  DOTAN ZOHAR

IPC: C12Q1/68

CPC classification number: C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention provides a method for classification of kidney tumors through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy.

Abstract translation: 本发明提供了通过分析特定微RNA和与其相关的核酸分子的表达模式来分类肾肿瘤的方法。 根据microRNA表达框架进行分类可以优化治疗，并确定具体的治疗方法。

公开(公告)号：WO2009153775A3

公开(公告)日：2010-03-18

申请号：PCT/IL2009000523

申请日：2009-05-26

Applicant: ROSETTA GENOMICS LTD ,  TEL HASHOMER MEDICAL INFRASTRU ,  ROSENFELD NITZAN ,  ROSENWALD SHAI ,  BARSHACK IRIS ,  LITHWICK YANAI GILA

Inventor： ROSENFELD NITZAN ,  ROSENWALD SHAI ,  BARSHACK IRIS ,  LITHWICK YANAI GILA

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y10T436/143333

Abstract: The present invention provides nucleic acid sequences that are used for identification, classification and diagnosis of lung cancers. The present invention further provides microRNA molecules, as well as various nucleic acid molecules relating thereto or derived therefrom, associated with specific types of lung cancers.

Abstract translation: 本发明提供了用于肺癌鉴定，分类和诊断的核酸序列。 本发明进一步提供与特定类型的肺癌相关的微小RNA分子以及与之有关或与其相关的各种核酸分子。

公开(公告)号：WO2010023658A2

公开(公告)日：2010-03-04

申请号：PCT/IL2009000809

申请日：2009-08-18

Applicant: ROSETTA GENOMICS LTD ,  TEL HASHOMER MEDICAL INFRASTRU ,  YEDA RES & DEV ,  GIVOL DAVID ,  RECHAVI GIDEON ,  ROSENFELD NITZAN

Inventor： GIVOL DAVID ,  RECHAVI GIDEON ,  ROSENFELD NITZAN

IPC: A61K31/7088 ,  A61K35/00 ,  C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/141 ,  C12N2330/10

Abstract: The invention relates in general to microRNA molecules associated with glioblastoma, as well as various molecules relating thereto. More specifically, the invention relates to methods and compositions for the treatment of glioblastoma and for treatment by a combination of microRNA molecules and Imatinib mesylate.

Abstract translation: 本发明一般涉及与成胶质细胞瘤相关的微RNA分子以及与其相关的各种分子。 更具体地说，本发明涉及用于治疗成胶质细胞瘤和通过微RNA分子和甲磺酸伊马替尼的组合治疗的方法和组合物。