公开(公告)号：WO2010058393A2

公开(公告)日：2010-05-27

申请号：PCT/IL2009/001075

申请日：2009-11-15

Applicant: ROSETTA GENOMICS LTD. ,  MOR RESEARCH APPLICATIONS ,  LITHWICK YANAI, Gila ,  BRENNER, Baruch

Inventor： LITHWICK YANAI, Gila ,  BRENNER, Baruch

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/178

Abstract: Described herein are compositions and methods for prognosis of colon cancer. The compositions are microRNA molecules associated with the prognosis of colon cancer, as well as various nucleic acid molecules relating thereto or derived thereof.

Abstract translation: 本文描述的是用于结肠癌预后的组合物和方法。 所述组合物是与结肠癌预后相关的微小RNA分子，以及与之有关的各种核酸分子或其衍生物。

公开(公告)号：WO2011024157A1

公开(公告)日：2011-03-03

申请号：PCT/IL2010/000462

申请日：2010-06-10

Applicant: ROSETTA GENOMICS LTD. ,  SITBON, Einat ,  LITHWICK YANAI, Gila ,  MEIRI, Eti ,  DROMI, Nir ,  LEVY, Asaf

Inventor： SITBON, Einat ,  LITHWICK YANAI, Gila ,  MEIRI, Eti ,  DROMI, Nir ,  LEVY, Asaf

IPC: C07H21/00 ,  A61K31/7088 ,  G01N33/48

CPC classification number: C12N15/113 ,  C12N2310/113 ,  C12N2310/141 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Disclosed are microRNA molecules, as well as various nucleic acid molecules relating thereto or derived therefrom Further disclosed are methods and compositions that can be used for diagnosis of cancer.

Abstract translation: 公开了微小RNA分子以及与其相关或衍生的各种核酸分子。进一步公开了可用于诊断癌症的方法和组合物。

公开(公告)号：WO2015175660A1

公开(公告)日：2015-11-19

申请号：PCT/US2015/030564

申请日：2015-05-13

Applicant: ROSETTA GENOMICS, LTD. ,  BARNETT-ITZHAKI, Zohar ,  LITHWICK YANAI, Gila ,  MEIRI, Eti ,  SPECTOR, Yael ,  BENJAMIN, Hila

Inventor： BARNETT-ITZHAKI, Zohar ,  LITHWICK YANAI, Gila ,  MEIRI, Eti ,  SPECTOR, Yael ,  BENJAMIN, Hila

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.

Abstract translation: 本发明提供了通过分析细针抽吸样品中特异性微小RNA的表达模式来分类甲状腺肿瘤的方法。 根据微小RNA表达特征的甲状腺肿瘤分类可以优化诊断和治疗，以及确定特异性特异性治疗。

公开(公告)号：WO2010018563A2

公开(公告)日：2010-02-18

申请号：PCT/IL2009/000764

申请日：2009-08-05

Applicant: ROSETTA GENOMICS LTD. ,  MOR RESEARCH APPLICATIONS LTD. ,  HOSHEN, Moshe ,  LITHWICK YANAI, Gila ,  LAHAV, Meir ,  AHARONOV, Ranit

Inventor： HOSHEN, Moshe ,  LITHWICK YANAI, Gila ,  LAHAV, Meir ,  AHARONOV, Ranit

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Described herein are compositions and methods for prognosis of malignant lymphoma. The compositions are microRNA molecules associated with the prognosis of lymphoma, as well as various nucleic acid molecules relating thereto or derived thereof.

Abstract translation: 本文描述了用于预后恶性淋巴瘤的组合物和方法。 该组合物是与淋巴瘤的预后相关的微RNA分子，以及与之相关或由其衍生的各种核酸分子。

公开(公告)号：WO2009153774A2

公开(公告)日：2009-12-23

申请号：PCT/IL2009/000497

申请日：2009-05-19

Applicant: ROSETTA GENOMICS LTD. ,  MOR RESEARCH APPLICATIONS ,  HOSEN, Moshe ,  LITHWICK YANAI, Gila ,  EITAN, Ram

Inventor： HOSEN, Moshe ,  LITHWICK YANAI, Gila ,  EITAN, Ram

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  A61K31/713 ,  A61K45/00 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/16 ,  C12Q2600/178

Abstract: Described herein are compositions and methods for the prediction of the prognosis of ovarian cancer subjects. The present invention further provides methods for distinguishing between histological subtypes of ovarian cancer tumors, and also methods and compositions for the treatment or prevention of ovarian cancer. Specifically the invention relates to microRNA molecules associated with said methods and compositions, as well as various nucleic acid molecules relating thereto or derived therefrom.

Abstract translation: 本文描述了用于预测卵巢癌患者预后的组合物和方法。 本发明还提供了用于区分卵巢癌肿瘤的组织学亚型的方法，以及用于治疗或预防卵巢癌的方法和组合物。 具体地说，本发明涉及与所述方法和组合物相关的微小RNA分子，以及与之有关的或从其衍生的各种核酸分子。

公开(公告)号：WO2012131670A2

公开(公告)日：2012-10-04

申请号：PCT/IL2012000131

申请日：2012-03-26

Applicant: ROSETTA GENOMICS LTD ,  LITHWICK YANAI GILA ,  BENJAMIN HILA

Inventor： LITHWICK YANAI GILA ,  BENJAMIN HILA

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention provides nucleic acid sequences that are used for identification, classification and diagnosis of lung cancers. The present invention further provides microRNA molecules, as well as various nucleic acid molecules relating thereto or derived therefrom, associated with specific types of lung cancers.

Abstract translation: 本发明提供了用于肺癌鉴定，分类和诊断的核酸序列。 本发明进一步提供与特定类型的肺癌相关的微小RNA分子，以及与之相关的或由其衍生的各种核酸分子。

公开(公告)号：WO2010018563A3

公开(公告)日：2010-04-15

申请号：PCT/IL2009000764

申请日：2009-08-05

Applicant: ROSETTA GENOMICS LTD ,  MOR RESEARCH APPLIC LTD ,  HOSHEN MOSHE ,  LITHWICK YANAI GILA ,  LAHAV MEIR ,  AHARONOV RANIT

Inventor： HOSHEN MOSHE ,  LITHWICK YANAI GILA ,  LAHAV MEIR ,  AHARONOV RANIT

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Described herein are compositions and methods for prognosis of malignant lymphoma. The compositions are microRNA molecules associated with the prognosis of lymphoma, as well as various nucleic acid molecules relating thereto or derived thereof.

Abstract translation: 本文描述了恶性淋巴瘤预后的组合物和方法。 组合物是与淋巴瘤的预后相关的微小RNA分子，以及与其相关或衍生的各种核酸分子。

公开(公告)号：WO2009153774A3

公开(公告)日：2010-04-15

申请号：PCT/IL2009000497

申请日：2009-05-19

Applicant: ROSETTA GENOMICS LTD ,  MOR RES APPLIC ,  HOSEN MOSHE ,  LITHWICK YANAI GILA ,  EITAN RAM

Inventor： HOSEN MOSHE ,  LITHWICK YANAI GILA ,  EITAN RAM

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  A61K31/713 ,  A61K45/00 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/16 ,  C12Q2600/178

Abstract: Described herein are compositions and methods for the prediction of the prognosis of ovarian cancer subjects. The present invention further provides methods for distinguishing between histological subtypes of ovarian cancer tumors, and also methods and compositions for the treatment or prevention of ovarian cancer. Specifically the invention relates to microRNA molecules associated with said methods and compositions, as well as various nucleic acid molecules relating thereto or derived therefrom.

Abstract translation: 本文描述了用于预测卵巢癌患者预后的组合物和方法。 本发明还提供了用于区分卵巢癌肿瘤的组织学亚型的方法，以及用于治疗或预防卵巢癌的方法和组合物。 具体地说，本发明涉及与所述方法和组合物相关的微小RNA分子，以及与之有关的或从其衍生的各种核酸分子。

公开(公告)号：WO2009153775A3

公开(公告)日：2010-03-18

申请号：PCT/IL2009000523

申请日：2009-05-26

Applicant: ROSETTA GENOMICS LTD ,  TEL HASHOMER MEDICAL INFRASTRU ,  ROSENFELD NITZAN ,  ROSENWALD SHAI ,  BARSHACK IRIS ,  LITHWICK YANAI GILA

Inventor： ROSENFELD NITZAN ,  ROSENWALD SHAI ,  BARSHACK IRIS ,  LITHWICK YANAI GILA

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178 ,  Y10T436/143333

Abstract: The present invention provides nucleic acid sequences that are used for identification, classification and diagnosis of lung cancers. The present invention further provides microRNA molecules, as well as various nucleic acid molecules relating thereto or derived therefrom, associated with specific types of lung cancers.

Abstract translation: 本发明提供了用于肺癌鉴定，分类和诊断的核酸序列。 本发明进一步提供与特定类型的肺癌相关的微小RNA分子以及与之有关或与其相关的各种核酸分子。

公开(公告)号：WO2012131670A3

公开(公告)日：2012-10-04

申请号：PCT/IL2012/000131

申请日：2012-03-26

Applicant: ROSETTA GENOMICS LTD ,  LITHWICK YANAI, Gila ,  BENJAMIN, Hila

Inventor： LITHWICK YANAI, Gila ,  BENJAMIN, Hila

IPC: C12Q1/68

Abstract: The present invention provides specific nucleic acid sequences for use in the identification, classification and diagnosis of various sub-types of lung cancers. The present invention permits one to accurately classify lung cancers based on their miR expression profile without further manipulation. Using microRNA microarray data generated from over two hundred formalin-fixed paraffin-embedded (FFPE) resection samples, fine needle aspiration (FNA) samples and fine needle biopsy (FNB) samples of primary lung cancer, microRNA expression profiles were identified that differ significantly for various sub-types of lung cancer.