公开(公告)号：WO2022251554A1

公开(公告)日：2022-12-01

申请号：PCT/US2022/031218

申请日：2022-05-26

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

Inventor： VASAN, Aditya ,  FRIEND, James ,  OROSCO, Jeremy ,  CHALASANI, Sreekanth ,  MAGARAM, Uri

IPC: A61N7/00 ,  B06B1/00 ,  C12N13/00 ,  H01L41/04

Abstract: A system of ultrasound based cellular stimulation may include a stimulation apparatus and a stimulation controller. The stimulation apparatus may include a transducer element formed from a single crystal piezoelectric material such as lithium niobate. The stimulation apparatus may deliver high magnitudes of acoustic pressure relative to its dimensions (e.g., size, weight, and/or the like) and without significant heating. The stimulation controller may determine a cellular response to ultrasound stimulation such as membrane deflection and transmembrane voltage change. The stimulation controller may determine, based on the predicted cellular response, parameters for an ultrasound stimulation treatment for a patient such as a magnitude and/or duration of an ultrasonic stimulus for achieving a desired magnitude of membrane deflection and/or transmembrane voltage changes. The ultrasound stimulation treatment may be administered to the patient by the stimulation apparatus operating in accordance with the parameters.

公开(公告)号：WO2020106971A1

公开(公告)日：2020-05-28

申请号：PCT/US2019/062638

申请日：2019-11-21

Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

Inventor： NAVLAKHA, Saket

IPC: G06F16/13 ,  G06F16/14 ,  G06F16/22 ,  G06K9/62

Abstract: A method for analytically determining novelty response, is provided. The method includes receiving a query item indicative of a response to a first stimulus, assigning in a filter engine multiple query hash functions to the query item, and comparing a first query hash function to a database item, each database item occupying a position indicative of a query hash function in the filter engine. The method also includes reducing a value for the database item when the database item is indicative of the first query hash function, and determining a novelty score for the first stimulus by computing a weighted sum of the values of the database items in the filter engine. A system and a memory storing instructions to cause the system to perform the above method are also provided.

公开(公告)号：WO2020041517A9

公开(公告)日：2020-02-27

申请号：PCT/US2019/047570

申请日：2019-08-21

Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

Inventor： MANOR, Uri ,  FANG, Linjing

IPC: A61B5/00 ,  G16H30/40

Abstract: A method to, is provided for collecting an image from a sample. The method includes selecting a radiation level for a first probe to meet a desired radiation dosage, and providing, with the first probe, a radiation at a selected point within a region of the sample. The method includes identifying a second selected point within the region of the sample based on a down sampling scheme, and providing a second radiation amount at the second selected point within the region of the sample. The method also includes interpolating a first datum and a second datum based on an up sampling scheme to obtain a plurality of data, and forming an image of the region of the sample with the plurality of data. A system to perform the above method and including the first probe is also provided.

公开(公告)号：WO2014052938A1

公开(公告)日：2014-04-03

申请号：PCT/US2013/062491

申请日：2013-09-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

Inventor： COLEMAN, Todd, Prentice ,  MA, Rui ,  KIM, Sanggyun ,  PARK, Cheolsoo ,  GIL DA COSTA, Ricardo ,  FUNG, Raynard ,  MESA, Diego

IPC: G06F19/00

CPC classification number: G06F17/30598 ,  A61B5/0482 ,  A61B5/0484 ,  A61B5/04842 ,  A61B5/04845 ,  A61B5/04847 ,  A61B5/0488 ,  A61B5/165 ,  A61B5/167 ,  A61B5/168 ,  A61B5/4011 ,  A61B5/4017 ,  A61B5/6814 ,  G06F17/3053 ,  G06F19/00 ,  G16H10/20

Abstract: Methods, devices, and systems are disclosed for producing cognitive and/or sensory profiles. In one aspect, a method to provide a cognitive or sensory assessment of a subject includes selecting a profile category from among a cognitive performance profile, a sensory performance profile, and a cognitive and sensory performance profile, presenting a sequence of stimuli to a subject, the sequence of stimuli based on the selected profile category, acquiring physiological signals of the subject before, during, and after the presenting the sequence of stimuli to produce physiological data, and processing the physiological data to generate an information set including one or more quantitative values associated with the selected profile category.

Abstract translation: 公开了用于产生认知和/或感觉简档的方法，装置和系统。 一方面，提供对受试者的认知或感官评估的方法包括从认知表现简档，感官表现简档以及认知和感觉性能轮廓中选择概况类别，向对象呈现刺激序列， 基于所选择的分类类别的刺激序列，在呈现所述刺激序列之前，之中和之后获取所述对象的生理信号以产生生理数据，以及处理所述生理数据以生成包括一个或多个定量值的信息集 与所选配置文件类别相关联。

公开(公告)号：WO2012009354A1

公开(公告)日：2012-01-19

申请号：PCT/US2011/043707

申请日：2011-07-12

Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES ,  CHICHILNISKY, Eduardo-Jose ,  JEPSON, Lauren ,  HOTTOWY, Pawel ,  DABROWSKI, Wladyslaw ,  LITKE, Alan, M.

Inventor： CHICHILNISKY, Eduardo-Jose ,  JEPSON, Lauren ,  HOTTOWY, Pawel ,  DABROWSKI, Wladyslaw ,  LITKE, Alan, M.

IPC: A61N5/06

CPC classification number: A61N1/0543 ,  A61N1/0541 ,  A61N5/06 ,  H05K999/00

Abstract: A method and apparatus for applying electrical signals in specific spatial patterns to selectively activate sensory cells. The method comprises interfacing a population of cells with two or more electrodes, identifying target cells within the population to activate by electrical signals; and applying electrical signals in a spatial pattern to the population via the electrodes, such that the target cells are selectively activated in the desired spatial pattern.

Abstract translation: 一种用于以特定空间图案施加电信号以选择性地激活感觉细胞的方法和装置。 该方法包括将一组细胞与两个或更多个电极接口，识别群体内的目标细胞以通过电信号激活; 以及通过电极将空间图案中的电信号施加到群体，使得靶细胞以期望的空间图案被选择性地激活。

公开(公告)号：WO2011009132A3

公开(公告)日：2011-01-20

申请号：PCT/US2010/042472

申请日：2010-07-19

Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES ,  NOEL, Joseph, P. ,  DELLAS, Nikki, M.

Inventor： NOEL, Joseph, P. ,  DELLAS, Nikki, M.

IPC: C12N9/12 ,  C12N15/54 ,  C12P9/00 ,  G01N33/58

Abstract: Provided herein are methods and compositions relating to the synthesis of isoprenoid diphosphates using a mutated isopentenyl phosphate kinase.

公开(公告)号：WO2010138750A2

公开(公告)日：2010-12-02

申请号：PCT/US2010/036456

申请日：2010-05-27

Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES ,  CENTER OF REGENERATIVE MEDICINE OF BARCELONA, SPAIN ,  RAYA, Angel ,  BUEREN, Juan Antonio ,  IZPISUA BELMONTE, Juan Carlos

Inventor： RAYA, Angel ,  BUEREN, Juan Antonio ,  IZPISUA BELMONTE, Juan Carlos

IPC: C12N5/074 ,  C12N5/10 ,  C12N15/12

CPC classification number: A61K48/005 ,  C12N5/0696 ,  C12N15/873 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/727 ,  C12N2510/00 ,  C12N2799/027 ,  C12N2830/60

Abstract: Methods and compositions for the generation and use of genetically corrected induced pluripotent stem cells are provided.

Abstract translation: 提供了用于产生和使用遗传修饰的诱导多能干细胞的方法和组合物。

公开(公告)号：WO2010121268A3

公开(公告)日：2010-10-21

申请号：PCT/US2010/031641

申请日：2010-04-19

Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES ,  DILLIN, Andrew ,  DURIEUX, Jennie

Inventor： DILLIN, Andrew ,  DURIEUX, Jennie

IPC: C12N15/113 ,  A61K31/713 ,  C07K14/435

Abstract: The invention relates to the field of longevity enhancement. More particularly, the invention provides compositions and methods relating to modulation of mitochondrial function. In certain embodiments, the invention provides methods and related compositions for the enhancement of longevity in an animal, comprising inhibition of one or more electron transport chain components, such as cco-1 and homologs thereof, in a tissue-specific manner in the animal.

公开(公告)号：WO2010083328A2

公开(公告)日：2010-07-22

申请号：PCT/US2010/021068

申请日：2010-01-14

Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES ,  DILLIN, Andrew ,  BAIGA, Thomas, J. ,  KAPERNICK, Erik ,  NOEL, Joseph, P.

Inventor： DILLIN, Andrew ,  BAIGA, Thomas, J. ,  KAPERNICK, Erik ,  NOEL, Joseph, P.

IPC: C07D241/08 ,  A61K31/496 ,  A61P25/00 ,  A61P43/00

CPC classification number: C07D241/08

Abstract: The disclosure provides methods and compositions useful for screening inhibitors of aggregation mediated proteotoxicity. The disclosure provides transgenic animals and cell useful for such screening. Also provided are compounds useful for inhibiting aggregation mediated proteotoxicity in a subject.

Abstract translation: 本公开提供了用于筛选聚集介导的蛋白毒性的抑制剂的方法和组合物。 本公开提供了用于这种筛选的转基因动物和细胞。 还提供了可用于抑制受试者中聚集介导的蛋白毒性的化合物。

公开(公告)号：WO2010008411A1

公开(公告)日：2010-01-21

申请号：PCT/US2008/082911

申请日：2008-11-07

Applicant: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES ,  ROTHLIN, Carla, V. ,  LEMKE, Greg, E.

Inventor： ROTHLIN, Carla, V. ,  LEMKE, Greg, E.

IPC: A61K39/39

CPC classification number: A61K39/3955 ,  A61K31/4196 ,  A61K31/519 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  Y02A50/411

Abstract: This disclosure concerns compositions and methods for immunoenhancement and/or immunosuppression. In certain embodiments, the disclosure concerns methods of using a TAM receptor inhibitor for immunoenhancement, for example as a vaccine adjuvant, for the treatment of sepsis, or for treating an immunocompromised subject. Also disclosed are methods of screening for immunoenhancing agents. In other embodiments, the disclosure concerns methods of using a TAM receptor agonist for immunosuppression, for example as a treatment for an autoimmune disorder, for the treatment of an allergy, or for treating graft-versus-host disease in a subject. Also disclosed are methods of screening for immunosuppressive agents.

Abstract translation: 本公开涉及用于免疫增强和/或免疫抑制的组合物和方法。 在某些实施方案中，本公开涉及使用TAM受体抑制剂进行免疫增强的方法，例如作为疫苗佐剂，用于治疗败血症或用于治疗免疫受损的受试者。 还公开了筛选免疫增强剂的方法。 在其他实施方案中，本公开涉及使用TAM受体激动剂进行免疫抑制的方法，例如作为自身免疫性疾病的治疗，用于治疗过敏或用于治疗受试者的移植物抗宿主病。 还公开了筛选免疫抑制剂的方法。