公开(公告)号：WO2017223435A1

公开(公告)日：2017-12-28

申请号：PCT/US2017/038980

申请日：2017-06-23

Applicant: THE TAXAS A&M UNIVERSITY SYSTEM ,  WASHINGTON STATE UNIVERSITY

Inventor： MORGAN, Cristine ,  GE, Yufeng ,  BROWN, David ,  BRICKLEMYER, Ross

IPC: G01N21/85 ,  G01N33/24

CPC classification number: E02D1/027 ,  G01J3/0208 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/108 ,  G01N21/01 ,  G01N21/8507 ,  G01N33/24 ,  G01N33/246

Abstract: Soil penetrometers capable of measuring soil reflectance along the direction of insertion of the penetrometer are provided. The penetrometer can house an array of sensors, such as, for example, a Vis-NIR reflectance sensor, a load cell, a displacement sensor, and a moisture sensor. The reflectance data collected using the penetrometer can allow the interpretation and quantification of soil constituents and contaminants at high vertical resolution, such as 3 cm or more.

Abstract translation: 提供了能够沿着硬度计插入方向测量土壤反射率的土壤透度计。 透度计可以容纳一系列传感器，例如Vis-NIR反射率传感器，测力传感器，位移传感器和湿度传感器。 使用透度计收集的反射率数据可以允许以高垂直分辨率（例如3厘米或更大）解释和量化土壤成分和污染物。

公开(公告)号：WO2020014594A1

公开(公告)日：2020-01-16

申请号：PCT/US2019/041571

申请日：2019-07-12

Applicant: THE TAXAS A&M UNIVERSITY SYSTEM

Inventor： SOMA, Shivatheja ,  GOHIL, Vishal, M. ,  SACCHETTINI, James, C. ,  GUTHRIE, Liam

IPC: A61K31/17 ,  A61K31/30 ,  A61K31/175 ,  A61K31/4745 ,  A61K45/06 ,  A61P25/02 ,  A61P25/14

Abstract: In an embodiment, the present disclosure relates to a method of restoring cytochrome c oxidase (CcO) activity in a subject in need thereof. In some embodiments, the method includes administering a therapeutically effective amount of elesclomol or analog thereof and rescuing defects of cells in the subject with deficiencies or mutations in at least one of SOD1, AT-1, API SI, COA6, SC02, COX6B1, CTRL ATOX1, CCS, GSX1, ATP7A, ATP7B, CLCN5, and CLCN7. In a further embodiment, the present disclosure relates to a method of treating disorders of copper metabolism. In some embodiments, the method includes administering a therapeutically effective amount of elesclomol or analog to a subject, where the disorder is caused by a deficiency or mutation to a gene including, without limitation, SOD1, AT-1, API SI, COA6, SC02, COX6B1, CTR1, ATOX1, CCS, GSX1, ATP7A, ATP7B, CLCN5, CLCN7, or combinations thereof.