公开(公告)号：WO2023076282A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/047742

申请日：2022-10-25

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： KHAN, Mansoor ,  RAHMAN, Ziyaur ,  REDDY, Indra, K. ,  DHARANI, Satish

IPC: A61K31/33 ,  A61K31/395 ,  A61K31/55

Abstract: In an embodiment, the present disclosure pertains to a stable formulation of a primary, secondary, and/or tertiary amino group containing composition that prevents or reduces formation of a nitroso impurity until the end of stated expiration or longer, or a method of making the stable formulation of a primary, secondary, and/or tertiary amino group containing composition. In some embodiments, the composition includes a drug having a primary, secondary, and/or tertiary amino group and a pharmaceutical excipient. In some embodiments, the pharmaceutical excipient is at least one of a protective pharmaceutical excipient or a non-protective pharmaceutical excipient. In some embodiments, the composition includes an antioxidant. In some embodiments, the composition includes a chelating agent.

公开(公告)号：WO2023075826A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/019737

申请日：2022-03-10

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： KHAN, Mansoor ,  RAHMAN, Ziyaur ,  REDDY, Indra K. ,  DHARANI, Satish

IPC: A61K31/155 ,  A61K31/341 ,  A61K31/343

Abstract: In an embodiment, the present disclosure pertains to a stable formulation of a primary, secondary, and/or tertiary amino group containing composition that prevents or reduces formation of a nitroso impurity, or a method of making the stable formulation of a primary, secondary, and/or tertiary amino group containing composition. In some embodiments, the composition includes a drug having a primary, secondary, and/or tertiary amino group and a pharmaceutical excipient. In some embodiments, the pharmaceutical excipient is at least one of a protective pharmaceutical excipient or a non-protective pharmaceutical excipient. In some embodiments, the pharmaceutical excipient is processed with an organic solvent.

公开(公告)号：WO2020206348A1

公开(公告)日：2020-10-08

申请号：PCT/US2020/026715

申请日：2020-04-03

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： CANNON, Carolyn, L. ,  SHAH, Kush ,  CHIRRA, Bhagath ,  CHEN, Qingquan ,  KHAN, Mansoor ,  WU, Hung-Jen

IPC: A61D1/02 ,  A61D7/00 ,  A61K9/00

Abstract: In an embodiment, a drug delivery system and method of use thereof to treat inflammation and bacterial pathogens including multi-drug resistant pathogens, such as MDR-Pseudomonas aeruginosa, or reactive oxygen species in a subject is provided. In some embodiments, the dmg delivery system includes a polymeric material, an excepient, an antioxidant agent, and an anti-inflammatory and antimicrobial agent. In some embodiments, the anti-inflammatory and antimicrobial agent is a salt of an anti-inflammatory agent and an antimicrobial agent formulated to provide a combination of antimicrobial and anti-inflammatory action from a single molecule. In some embodiments, the combined anti-inflammatory and antimicrobial agent is a silver salt of ibuprofen. In other embodiments, the combined anti-inflammatory and antimicrobial agent is unmodified, native ibuprofen.